13757 papers
In a blinded expert evaluation of guideline-based juvenile idiopathic arthritis questions, GPT-5.6 Sol significantly outperformed Gemini 3.1 Pro and Claude Opus 5 in accuracy, usability, and overall quality, supporting the need for supervised rather than autonomous use of large language models in pediatric rheumatology.
This retrospective study demonstrates that salvage CT-guided brachytherapy provides favorable local control for patients with postoperative vaginal recurrence of endometrial cancer, particularly when the high-risk clinical target volume receives a dose of at least 67.3 Gy, although distant metastasis remains a significant cause of treatment failure.
This nationwide observational study reveals that machine learning models and medical dispatchers exhibit distinct, complementary recognition patterns for out-of-hospital cardiac arrest calls, with ML models performing better in specific scenarios like home-based arrests by lone lay callers, while dispatchers excel when CPR is already in progress or multiple people are present.
This case report highlights a rare diagnostic pitfall where a pericardial effusion presented as isolated right upper quadrant pain with elevated liver enzymes, mimicking acute hepatobiliary disease in a patient with HIV and a history of tuberculosis, thereby underscoring the critical need to consider cardiac pathology in atypical abdominal presentations to prevent life-threatening cardiac tamponade.
In the 36-month WATCH-PD study, composite digital gait and speech measures demonstrated the most consistent and significant tracking of early Parkinson's disease progression, outperforming other digital metrics that were confounded by learning effects or symptomatic treatments.
This retrospective study of 114 eyes with myopic astigmatism and asymmetric corneas found that combining femtosecond LASIK with corneal cross-linking using either 3.6 J/cm² or 2.7 J/cm² UVA energy protocols yielded excellent, safe, and stable visual and refractive outcomes over 12 months, with no statistically significant differences between the two energy levels.
This study reveals that extratumoral insulin-like growth factor-1 (IGF-1) secreted by stromal fibroblasts drives adaptive resistance to HER2-targeted tyrosine kinase inhibitors in breast cancer by activating a PI3K/FOXO/NRF2 redox axis that restores cellular homeostasis and promotes immunosuppressive macrophage polarization, suggesting that co-targeting this microenvironmental pathway could improve therapeutic efficacy.
This prospective observational cohort study of 271 Chinese orthopedic patients demonstrates that perioperative poor sleep impairs postoperative recovery in a dose-dependent manner, with a critical threshold of two or more nights of disturbance causing significantly greater and more persistent deficits in quality of recovery compared to a single night.
This study demonstrates that implanted intramuscular electromyographic signals can provide stable, long-term continuous control of prosthetic fingers in both a monkey and a human without the need for decoder recalibration, as users adapt their muscle activation patterns to maintain performance over several months.
In patients with type 2 diabetes, [18F]NaF PET radiomics features significantly outperform baseline clinical variables, coronary calcium scores, and maximum target-to-background ratios in predicting two-year coronary calcium score progression at both the patient and artery levels.