📄 Category

medicine

3708 papers

📄 medicine

Deciphering Liver-Kidney Meridian Tropism and Shared Molecular Modules of Antitumor Herbal Medicines in Ovarian, Cervical, and Bladder Cancers

This study elucidates the molecular basis for the Traditional Chinese Medicine principle of "same treatment for different diseases" in ovarian, cervical, and bladder cancers by demonstrating that liver-kidney meridian-associated herbal compounds, particularly β-sitosterol and quercetin, converge on shared hub targets (AKT1, MYC, TP53, EGF, MMP9) and the PI3K-Akt pathway to regulate tumor progression and drug resistance.

Sheng Zhang, Tian Zhang, Xiuxiu Zhu2026-07-15
📄 medicine

Perioperative outcomes for children with preoperative upper respiratory tract infection symptoms in elective non-cardiac surgery after COVID-19 pandemic at a large tertiary hospital in China: a retrospective cohort study

This retrospective cohort study of children undergoing elective non-cardiac surgery in China found that while preoperative upper respiratory tract infection symptoms were associated with increased emergence respiratory adverse events and longer PACU stays in the post-COVID-19 era, these risks were not significantly elevated in the pre-pandera period, suggesting that the impact of URTI on perioperative outcomes is modulated by the temporal context of the pandemic.

Ruochen Pan, Yuan Bi, Tianqing Yan, Jianbo Deng, Zhang Tian, Zitong Zhang, Aijun Xu2026-07-15
📄 medicine

Three Thiol-Reactive Reagents drive Synergistic Lethality in Glioblastoma cells

This study demonstrates that a synergistic triple-combination of thiol-reactive reagents (acrylamide, auranofin, and buthionine sulfoximine) effectively induces lethal oxidative stress and cell death in glioblastoma cells by disrupting redox signaling pathways while sparing primary neuronal cultures, offering a promising therapeutic strategy for treating glioblastoma.

Ofer y Kashi, Adi Cohen, Kathleen Earhart, Jonathan David Elliot, MO Ramirez Denise, Sukanya Rauniyar, Ghazi Qureshi, Ga (…)2026-07-15
📄 medicine

Development and external validation of a laboratory-free clinical decision-support model for sepsis prediction at emergency department triage: a retrospective cohort study

This retrospective cohort study developed and externally validated a laboratory-free, nurse-assessable sepsis prediction model using XGBoost that demonstrated strong internal performance but poor external generalizability, suggesting that a simplified five-variable version may offer better cross-institutional transportability for emergency department triage despite requiring further prospective validation.

Chao Ding, Qingjiang Lyu2026-07-15
📄 medicine

Patterns of musculoskeletal disorders among Cameroonian healthcare workers and their associations with physical activity, sedentary behavior, and health-related quality of life

This cross-sectional study of Cameroonian healthcare workers reveals a high prevalence of musculoskeletal disorders, particularly in the lower back and neck, which are significantly associated with factors such as age, occupation, sedentary behavior, and poor physical health-related quality of life, while moderate physical activity serves as a protective factor.

Jerson Mekoulou Ndongo, William Mbang Bian, . Ahmadou, Ange Ulrich Le Roy Tabunguia, Hassane Ahmet Malam Moussa, Emmanue (…)2026-07-14
📄 medicine

Scalable generation of polyfunctional therapeutic virus-specific T cells with tissue-homing features and resident-memory-like plasticity across viral targets

This study establishes a rapid, scalable, and GMP-compatible 10-day manufacturing platform that generates highly specific, polyfunctional, and allogeneic virus-specific T cells with tissue-homing features and resident-memory-like plasticity, effectively overcoming precursor frequency limitations for treating refractory viral infections.

Francesc Rudilla, Rut Mora-Buch, Emma Enrich, Alexia Gonzalez-Sevilla, Maria Tomás-Marín, Miriam García Bosca, Mireia An (…)2026-07-14
📄 medicine

Impact of different physical examination frequencies on biochemical indicator variability in community-dwelling older adults: an 8-year retrospective cohort study

This 8-year retrospective cohort study of over 57,000 older adults in Shanghai reveals that while higher frequencies of health examinations are significantly associated with improved long-term trajectories for renal and hepatic function and LDL cholesterol, they are paradoxically linked to faster increases in BMI and triglycerides, suggesting that regular monitoring must be integrated with lifestyle interventions for comprehensive health promotion.

Haiyang Zhang, pei Lian, Tingting Wu, Peiyu Xu, Ting Zhou, Junying Yu, Hongkai Tao, Hong Yu2026-07-14
📄 medicine

Post-discharge survival and incomplete postnatal care continuum among newborns discharged from hospital-based newborn care in Ethiopia: a prospective cohort study

This prospective cohort study of 896 newborns in Ethiopia found that while post-discharge survival rates were high, the completion of the full postnatal care continuum remained low, with key predictors for care utilization including longer facility stays, maternal awareness of danger signs, and knowledge of follow-up timing.

Alula M Teklu, Wendemaghen Gezahegn, Wondimye Ashenafi, Eskinder Wolka, Tilahun Haregu, James A. Litch2026-07-14
📄 medicine

KIF24 depletion induces Fe–S-dependent mitochondrial dysfunction and AMPK/p53/SLC7A11 mediated ferroptosis in gastric cancer

This study identifies KIF24 as a critical oncogenic factor in gastric cancer that confers resistance to ferroptosis by maintaining Fe–S-dependent mitochondrial function, and demonstrates that its depletion triggers cell death via the AMPK/p53/SLC7A11 signaling axis, highlighting KIF24 as a promising therapeutic target.

Ji-Bin Liu, Hai-Xia Zhu, Chun-Yan Gu, Qi ying Yu, Jing-Jing Shao, Li Song, Yu Wu2026-07-14
📄 medicine

Reversible Optic Nerve Conduction Recovery After Teprotumumab in Dysthyroid Optic Neuropathy: Longitudinal Visual Evoked Potential Findings

This case report demonstrates that teprotumumab therapy in a patient with dysthyroid optic neuropathy led to significant clinical and electrophysiologic recovery, evidenced by the normalization of visual acuity and the reversal of delayed visual evoked potential latencies, supporting serial VEP assessment as an objective biomarker for treatment response.

Mizuki Tagami, Taichi Higashida, Gen Kinari, Yusuke Haruna, Shigeru Honda2026-07-14