3171 papers
This study analyzing over 180,000 patients demonstrates that common excess-weight metrics misrepresent actual weight loss due to baseline BMI dependence and fail to predict metabolic outcomes after bariatric surgery, suggesting that direct measurement of glycemic response should be prioritized for patients with type 2 diabetes.
While endovascular aneurysm repair (EVAR) significantly reduces the risk of postoperative delirium compared to open surgical repair in patients under 80 by mitigating surgical stress, this protective advantage diminishes in octogenarians due to overwhelming intrinsic vulnerability, necessitating aggressive geriatric co-management rather than relying solely on minimally invasive techniques.
In a large population-based study, higher adherence to healthful plant-based dietary patterns was significantly associated with reduced odds of severe periodontitis and lower periodontal inflamed surface area, while unhealthful plant-based patterns showed the opposite effect, with systemic inflammation partially mediating these relationships.
This study identifies the MIF-SERPINE1-PI3K-Akt/NF-κB axis as a critical driver of intervertebral disc degeneration and demonstrates that an injectable, sustained-release hydrogel loaded with the MIF antagonist alphitolic acid effectively blocks this pathway to attenuate inflammation and restore extracellular matrix homeostasis in a rat model.
This pharmacovigilance study utilizing the FAERS database characterizes the heterogeneous clinical phenotypes of tranexamic acid-associated thrombotic events, revealing that venous thromboembolism is the most frequent and severe type while cerebrovascular thrombosis disproportionately affects young females, thereby highlighting the need for enhanced risk stratification in specific high-risk populations.
This 2019 cross-sectional study of 400 secondary school students in Bukavu, DRC, reveals a high 6-month prevalence of non-febrile headaches (67.5%), predominantly migraines, which significantly impact academic performance and show marked sex differences with females experiencing more frequent and severe symptoms, highlighting a critical unmet need for screening and preventive care in this low-resource setting.
This cross-sectional study of 153 undergraduate nursing students in rural Queensland found that while community interaction increased during placements, a sense of belonging was more strongly associated with the breadth of active community participation and repeated rural experiences than with mere exposure or interaction frequency.
This prospective study of 464 cervical cancer patients in Zambia found that prior screening was significantly associated with younger age, higher socioeconomic status (lower SDOH scores), and HIV-positive status, highlighting the critical role of social determinants and HIV care integration in screening uptake.
This study demonstrates that S-(-)-limonene incorporated into stable nanoemulsions and nanoemulgels exhibits significant antibacterial activity against *Klebsiella pneumoniae*, supporting its potential as a candidate for treating skin wound infections.
This study identifies SLC7A11 as an epigenetically regulated hub gene that links ferroptosis to immune remodeling in ovarian cancer, where its high expression correlates with macrophage enrichment, CD8+ T cell depletion, and poor patient survival, ultimately supporting the development of a robust prognostic nomogram.