📄 Category

medicine

7905 papers

📄 medicine

Real World Outcomes and Predictive Factors of Pirtobrutinib in Mantle Cell Lymphoma After Failure of Covalent Bruton Tyrosine Kinase Inhibitors

This multi-center retrospective study of 213 mantle cell lymphoma patients who failed covalent BTK inhibitors reveals that while pirtobrutinib yields modest outcomes as a non-bridging therapy (34% ORR, 5.3-month median PFS) and is influenced by factors like short prior cBTKi exposure and TP53 mutations, it demonstrates significant efficacy as a bridging therapy for 75% of patients proceeding to CAR-T or allogeneic transplant.

Tycel Phillips, Paolo Lopedote, Lu Chen, Adrienne Nedved, Alexey Danilov, Taylor Brooks, Marcus Watkins, Roua Arian, Yun (…)2026-09-04
📄 medicine

Safety and efficacy of pertuzumab and trastuzumab in patients with HER2-Positive metastatic colorectal cancer: comparison of intravenous and subcutaneous formulations. ​

This retrospective study demonstrates that the subcutaneous formulation of pertuzumab and trastuzumab offers comparable efficacy and a lower incidence of infusion-related reactions to the intravenous formulation in patients with HER2-positive metastatic colorectal cancer, while significantly reducing treatment process time.

Momoka Furuoka, Saori Mishima, Akihito Kawazoe, Yu Miyashita, Yuki Matsubara, Tadayoshi Hashimoto, Izuma Nakayama, Daisu (…)2026-09-04
📄 medicine

Toward Optimising Multiple Sclerosis MRI Protocols: A Comparative Study of Lesion Detection and Quantitative Image Quality Across MRI Sequences

This comparative study of 23 multiple sclerosis patients demonstrates that 3D FLAIR significantly improves lesion detection over conventional 2D FLAIR, while T2-weighted imaging provides superior contrast-to-noise ratios, supporting the integration of both sequences into an optimized hybrid MRI protocol for more accurate disease assessment.

Sara Bassam Al-Qaralleh, Marwan Alshipli, Sahar Mahmoud Abd elsalam, Ahmed Sayed Abd El Basset2026-09-04
📄 medicine

Severe MASLD and Metabolic Burden Are Associated with Reduced HBsAg Clearance During Pegylated Interferon Therapy in HBeAg-Negative Chronic Hepatitis B

In HBeAg-negative chronic hepatitis B patients with low baseline HBsAg undergoing pegylated interferon therapy, severe metabolic dysfunction-associated steatotic liver disease (MASLD) and a high cumulative metabolic burden are independently associated with reduced HBsAg clearance, whereas mild to moderate MASLD does not significantly impair treatment response.

Pengxuan Wu, Jianxia Dong, Dacheng Sheng, Lilin Wang, Xinyue Meng, Jing Zhao, Shan Ren, Sujun Zheng2026-09-04
📄 medicine

Characterisation of Bedaquiline Resistance-Associated Mutations in Drug-Resistant Tuberculosis Phenotypes

This study characterizes bedaquiline resistance-associated mutations in Eswatini, revealing a 36% resistance prevalence and identifying the Rv0678_p.Met146Thr mutation as the primary driver of phenotypic resistance while highlighting significant associations between specific genetic variants and various drug-resistant tuberculosis phenotypes.

Talent C. Dlamini, Yasmeen Thandar, Brenda T. Mkhize2026-09-04
📄 medicine

Severe Injuries in Competitive Cycling During an Olympic Cycle: Injury Patterns, Time Loss, and Return-to-Performance Outcomes

This retrospective study of 192 cyclists over an Olympic cycle reveals that severe injuries, affecting 37.5% of athletes, predominantly manifest as traumatic upper extremity fractures during competition and overuse knee injuries during training, with significant variations in time loss and return-to-performance outcomes across specific injury types and disciplines.

Christophe LAMBERT, Maxime Lambert, Marlene Galandi, Bernd WOLFARTH, Casper GRIM, Sven SHAFIZADEH, Ramona RITZMANN2026-09-04
📄 medicine

Effects of Home-Based Gait Training with Exoskeleton Robot on Lower Limb Motor Function and Hip Stability in Children with Type 2 Spinal Muscular Atrophy: A Single-Arm Self-Controlled Trial

This single-arm self-controlled trial demonstrates that a 12-week home-based exoskeleton gait training program is safe and feasible for children with type 2 spinal muscular atrophy, resulting in significant improvements in daily living activities and lower-limb muscle strength, alongside positive but non-significant trends in gross motor function and hip stability.

Huawei Zhang, Xiaohua Guo, Wanpeng Chang, Minggang Yi, Yujie Yang, Yanbo Cao, Jicong Liu, Ge Wang, Feifei Wang, Tian Wan (…)2026-09-04
📄 medicine

Leveraging electronic medical and financial records to estimate financial costs of delivering health services in health facilities: a multi-site retrospective study in Burundi

This multi-site retrospective study in Burundi leverages electronic medical and financial records to estimate that healthcare costs increase with facility level, revealing distinct cost drivers (medicines in health centers versus personnel in hospitals) and arguing for differentiated reimbursement tariffs and targeted management strategies to support universal health coverage.

Alain NDAYIKUNDA, Frank VERBEKE, Joseph NYANDWI, Manassé NIMPAGARITSE, Ronald BUYL2026-09-04