13757 papers
This study demonstrates that nigral iron accumulation in Parkinson's disease is spatially coupled with normative mitochondrial maps and oxidative stress-related gene expression, providing a molecular framework for selective neuronal vulnerability in subcortical regions.
This case report describes the successful transvenous extraction of a 20-year-old dual-coil passive-fixation ICD lead from an 85-year-old patient with a pocket infection using a rotational mechanical dilator sheath after laser sheath failure, followed by the implantation of a subcutaneous ICD.
This study developed and internally validated clinical prediction models using patient-reported outcomes and demographic data to effectively identify dyssynergic defecation and rectal sensory abnormalities in patients with functional constipation, offering a potential non-invasive screening tool prior to high-resolution anorectal manometry.
This exploratory qualitative study identifies key facilitators, such as real-time feedback and social support, and barriers, including digital literacy and data privacy concerns, that influence the adoption and sustained use of wearable devices for home-based secondary stroke prevention among older adults in China, ultimately advocating for patient-centered, age-friendly design and integrated healthcare pathways.
This randomized, crossover trial demonstrates that standardized periocular acupoint massage immediately lowers intraocular pressure in healthy young adults more effectively than sham stimulation by specifically expanding the aqueous humor outflow pathway and modulating autonomic function.
This cross-sectional study of 1,213 Japanese women reveals that sleep quality varies significantly across four reproductive life stages, with mothers of infants experiencing the poorest sleep and distinct modifiable predictors—such as morning fatigue, menopausal symptoms, and screen use habits—emerging as key targets for stage-specific public health interventions.
This study demonstrates that quantitative, frame-based measurement of esophageal transit time on preoperative barium esophagrams exhibits excellent reliability when averaged across three readers, while both quantitative and qualitative binary classifications at a 6-second threshold show moderate inter-reader agreement, suggesting that qualitative assessment may serve as a practical preliminary estimate.
This case report describes the first instance in the Arab region of successfully treating medically refractory veno-occlusive erectile dysfunction in a 67-year-old man using percutaneous deep dorsal penile vein embolization with a Glubran and lipiodol mixture, demonstrating the feasibility of this minimally invasive approach following a structured diagnostic workup.
This study demonstrates that vitreous cytokines, particularly IL-6, G-CSF, and IL-8, serve as highly accurate diagnostic biomarkers for distinguishing bacterial post-cataract endophthalmitis from non-infectious controls and moderately predict culture positivity, while also revealing that increased central macular thickness in affected eyes is not directly correlated with the measured cytokine levels.
This study of emergency medicine physicians in a Saudi tertiary hospital reveals that while they generally hold favorable attitudes toward older adults, higher levels of geriatric knowledge and personal contact with the elderly are significantly associated with reduced ageism, highlighting the need for enhanced geriatric education and meaningful intergenerational interaction to improve emergency care.