medicine papers | Gist.Science

Early Physiological Trajectory-Based Phenotyping in Surgical Intensive Care Unit Patients: A Gaussian Mixture Modeling Approach Integrating Temperature, Central Venous Pressure, Fluid Balance, and Glycemic Dynamics

This retrospective study utilized Gaussian Mixture Modeling on the first 72 hours of multidimensional physiological data from 3,493 surgical ICU patients to identify five distinct trajectory phenotypes that reveal clinically meaningful subgroups with varying disease severity and resource utilization patterns, including a unique high-risk, zero-mortality group characterized by advanced age and compensated physiology.

Sai Chen, Jin Li, Yanping Kuang, Xuan Dai, Hongyan Wei, Yongjun Liu, Chunlin Hu2026-07-14

📄 medicine

A Dual-Phase Multimodal Transformer Integrating Pre- and Post-Thrombectomy Computed Tomography and Clinical Features to Predict 90-Day Functional Outcome After Mechanical Thrombectomy

This study developed and externally validated a dual-phase multimodal Transformer model that integrates pre- and post-thrombectomy CT images with clinical features to accurately predict unfavorable 90-day functional outcomes in acute ischemic stroke patients who exhibit immediate post-procedural cerebral hyperdensity, outperforming standalone models and enhancing physician prognostic accuracy.

Jiahong Fu, Yuhan Chen, YUjie Shen, Jiayi Hong, Shiying Gai, Huan Liu, Yan Li, Lina Jiang, Xiaochao Yu, Dekuai Tong, Son (…)2026-07-14

📄 medicine

Longitudinal CT-derived Growth Metrics Associated with Invasive Lung Adenocarcinoma in Subsolid Pulmonary Nodules

This study demonstrates that while a single follow-up CT scan is as effective as longitudinal growth metrics for identifying invasive lung adenocarcinoma in subsolid nodules, annualized mass growth remains a critical independent predictor of invasion even in lesions that have not yet developed an overt solid component.

Xiaofeng Wu, Yang Tao, Silin Du, Fajin Lv2026-07-14

📄 medicine

Dinutuximab beta-based first-line maintenance therapy for newly diagnosed high-risk neuroblastoma following a COG-based pathway: a single-center real-world study in China

This single-center Chinese study demonstrates the feasibility and safety of implementing a COG-based pathway for newly diagnosed high-risk neuroblastoma followed by dinutuximab beta maintenance, reporting a 3-year event-free survival of 69.2% with manageable toxicity profiles and highlighting the importance of cycle-stratified safety analysis and monitoring for CNS-related relapses.

Meng Yi, Senmin Chen, Huanli Xu, Chao Liu, Huiping Lang, Xiuli Yuan2026-07-14

📄 medicine

White Matter Hyperintensity Burden Is Associated With Altered Functional Network Topology and Enhanced Structural-Functional Coupling in Cerebral Small Vessel Disease

This study demonstrates that in patients with cerebral small vessel disease, a higher burden of white matter hyperintensities is associated with altered functional network topology characterized by increased local segregation and enhanced structural-functional coupling, suggesting that white matter injury drives brain network reorganization and may serve as a key imaging marker for disease severity.

Fan Yang, Hanjiaerbieke Kukun, Xiang Tan, Tao Xiong, Chao Guo2026-07-14

📄 medicine

Excessive daytime sleepiness increases dementia risk in cognitively unimpaired Parkinson’s disease patients over 12 years

This 12-year longitudinal study of cognitively unimpaired Parkinson's disease patients reveals that excessive daytime sleepiness is a significant predictor of accelerated cognitive decline and an increased risk of conversion to dementia, independent of other clinical factors.

Lyna Mariam El Haffaf, Lucas Ronat, Oury Monchi2026-07-14

📄 medicine

Dynamic Monitoring of Procalcitonin for Early Prediction of Pancreatic Necrosis

This retrospective study of 190 acute pancreatitis patients demonstrates that a 48-hour procalcitonin (PCT) level exceeding 0.23 ng/mL is a superior independent predictor of pancreatic necrosis compared to traditional scoring systems and other biomarkers, offering a rapid and effective tool for early clinical identification.

xiaxia weng, junchao zhang2026-07-14

📄 medicine

Chest CT-Estimated Aortic Arch Calcification and Its Prognostic Value for Cardiovascular and All-Cause Mortality in Maintenance Hemodialysis Patients

This retrospective cohort study of 205 maintenance hemodialysis patients demonstrates that aortic arch calcification scores derived from routine chest CT scans are independent predictors of both cardiovascular and all-cause mortality, offering a promising tool for risk stratification in this population.

Yiyi Gao, Kequan Ding, Yongyao Wu, Qiaojing Xia, Pengjie Xu2026-07-14

📄 medicine

Influence of Tumor Size on Survival in Pediatric and Adolescent Patients with Malignant Peripheral Nerve Sheath Tumors: A SEER Database Analysis with Single-Center Validation

This study utilizing the SEER database and validated by a single-center cohort identifies tumor size as an independent prognostic factor for survival in pediatric and adolescent patients with malignant peripheral nerve sheath tumors, establishing an optimal age-stratified cutoff of approximately 5.75 cm for risk stratification.

Qiaoyin Liu, Zhixuan Fang, Ping Chu, Yifan Liu, Yanzhen Li, Nian Sun, Junlong Tan, Zhiyong Liu, Shengcai Wang2026-07-14

📄 medicine

Parathyroid Hormone Suppression and Calcium Homeostasis Shift in Type 2 Diabetes with Osteoporosis: A Propensity Score-Matched Cross-Sectional Study

This propensity score-matched cross-sectional study reveals that in Type 2 diabetes patients with osteoporosis, bone turnover markers are comparable to those in pure diabetes, challenging the classic low-turnover hypothesis, while distinct PTH suppression with mild hypercalcemia and a weakened glycemic-bone turnover correlation suggest unique alterations in calcium homeostasis and metabolic regulation.

Xiaotian Huang, Yiwen Wang, Hao Chen, Jiaoyang Zheng2026-07-14

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