3708 papers
This study demonstrates that polyethyleneimine-coated Ligustrazine-loaded liposomes, developed via thin-film hydration and validated through molecular docking and in vivo rat models, effectively target the kidneys and mitigate acetaminophen-induced nephrotoxicity, offering a promising drug repurposing strategy for treating kidney damage.
This cross-sectional study of Turkish dental students reveals that while clinical training significantly improves both self-reported oral health attitudes and objective periodontal status, a marked discordance exists between the two measures, particularly regarding gender-specific improvements in clinical findings that are not reflected in self-reported behaviors.
This case-control study of nearly 10,000 participants across nine Latin American countries identifies several modifiable environmental risk factors for Parkinson's disease, including pesticide and metal exposure, rural living, well water consumption, and head trauma, while confirming protective effects of caffeine and tobacco, collectively accounting for an estimated 13.7% of the disease burden in the region.
The paper proposes SINÚ-CCUM, an integrated community-based intervention for Montería, Colombia, that addresses geographical, sociocultural, administrative, and operational barriers to cervical cancer screening by training a multidisciplinary team and establishing a simplified diagnostic pathway coordinated among key health stakeholders.
This retrospective study of 8,413 patients across five rural Vision Centres in Karnataka, India, demonstrates that over a 12-month period, these facilities effectively detected refractive errors leading to a 29% spectacle conversion rate, facilitated 1,720 cataract surgeries, and integrated systemic disease screening for over 2,400 individuals.
Manganese dioxide (MnO₂) nanomaterials enhance anti-tumor immunity by chelating excess extracellular potassium in the tumor microenvironment, thereby reversing high-K⁺-induced metabolic dysfunction and aberrant TCF7 upregulation to restore the normal function of stem-like CD8⁺ T cells.
This study demonstrates that genipin effectively ameliorates experimental rheumatoid arthritis in rats by suppressing pro-inflammatory cytokines and hematological abnormalities while promoting anti-inflammatory responses, a mechanism supported by molecular docking and favorable ADMET profiles.
This study of female volleyball athletes reveals that knee pain risk is significantly driven by the interaction between specific mobility deficits (particularly foot posture and dorsiflexion range of motion) and strength limitations, where the combination of these factors creates a substantially higher likelihood of pain than either deficit alone.
This case–control study of a Libyan population identifies Factor V Leiden and Factor V H1299R polymorphisms as significant genetic risk factors for coronary artery disease, while finding no statistically significant association with the Prothrombin G20210A variant.
This study reveals that while absolute rates remain low, constipation-associated mortality in the United States has significantly increased since 2012, disproportionately affecting older adults, women, and non-metropolitan residents, with the rise driven by downstream complications rather than underlying causes or substance use disorders.