📄 Category

medicine

3743 papers

📄 medicine

Joint Associations of Anthropometric Indices and the Cholesterol– High‑Density Lipoprotein–Glucose Index with Collateral Circulation Formation in Patients with Chronic Total Occlusion of Coronary Arteries: A Cross‑Sectional Study

This cross-sectional study of 841 patients with chronic total occlusion reveals that cholesterol–high-density lipoprotein–glucose (CHG) modified anthropometric indices, particularly CHG-ABSI and CHG-WWI, are strongly and independently associated with poor collateral circulation formation, outperforming the CHG index alone in identifying patients with an adverse metabolic-adiposity phenotype.

Xueyu Lv, Junqi Yu, Xiaoyan Lu, Zhihang Du, Dan Li2026-07-14
📄 medicine

Molecular spectrum and genotype-phenotype correlations in Romanian patients with neurofibromatosis type 1

This study characterizes the molecular spectrum and genotype-phenotype correlations in 162 Romanian patients with neurofibromatosis type 1, revealing 17 novel variants, significant phenotypic variability even among individuals with identical genotypes, and the importance of comprehensive genomic testing for identifying dual diagnoses and guiding multidisciplinary surveillance.

Teodora Toc, Nicoleta Ioana Andreescu, Catalin Vasile Munteanu, Iulia-Elena Simina, Florina Stoica, Aurora Alexandra Jur (…)2026-07-14
📄 medicine

Feasibility of a primary care-based adapted physical activity program for older adults with chronic conditions: the CAPA-CITY 70 pilot study

The CAPA-CITY 70 pilot study demonstrates that a primary care-based, supervised adapted physical activity program is feasible and highly acceptable for community-dwelling adults aged 70 and older with chronic conditions, achieving high completion and adherence rates while supporting the need for larger controlled trials to assess long-term effectiveness.

Emile Escourrou, Thomas Richaud, Aurore Palmaro, Bruno Chicoulaa, Sandrine Andrieu, Stéphane Oustric2026-07-14
📄 medicine

Impact of catheter-induced flow compromise on the presence of multiple ischemic lesions in endovascular treatment of posterior circulation aneurysms: a two-center retrospective study

This two-center retrospective study of 108 patients demonstrates that catheter-induced flow compromise, driven primarily by vertebral artery tortuosity and including both complete wedges and incomplete flow stasis, is a strong independent predictor of multiple new ischemic lesions following endovascular treatment of posterior circulation aneurysms, underscoring the need for rigorous preoperative anatomical assessment and intraprocedural risk-avoidance strategies.

Nagatsuki Tomura, Kento Asakura, Tomoyuki Tsumoto, Fukutaro Ohgaki, Jo Sasame, Shigeo Matsunaga, Takashi Shuto2026-07-14
📄 medicine

Emergency Presentations and Predictors of Adverse Outcomes in Systemic Lupus Erythematosus: A Retrospective Cohort Study

This retrospective cohort study of 50 SLE patients presenting to the emergency department found that while immunological markers and complement depletion are associated with severe disease, the clinical severity of the presentation itself is the strongest predictor of ICU admission and mortality.

Emad Elshebiny, Ahmed Shaltoot, Amr Hussien Ahmed Zaki, Enas Sobhy Zahran, Athar Fekry Lasheen, Mohammed Khalil, Mohamed (…)2026-07-14
📄 medicine

Early Physiological Trajectory-Based Phenotyping in Surgical Intensive Care Unit Patients: A Gaussian Mixture Modeling Approach Integrating Temperature, Central Venous Pressure, Fluid Balance, and Glycemic Dynamics

This retrospective study utilized Gaussian Mixture Modeling on the first 72 hours of multidimensional physiological data from 3,493 surgical ICU patients to identify five distinct trajectory phenotypes that reveal clinically meaningful subgroups with varying disease severity and resource utilization patterns, including a unique high-risk, zero-mortality group characterized by advanced age and compensated physiology.

Sai Chen, Jin Li, Yanping Kuang, Xuan Dai, Hongyan Wei, Yongjun Liu, Chunlin Hu2026-07-14
📄 medicine

A Dual-Phase Multimodal Transformer Integrating Pre- and Post-Thrombectomy Computed Tomography and Clinical Features to Predict 90-Day Functional Outcome After Mechanical Thrombectomy

This study developed and externally validated a dual-phase multimodal Transformer model that integrates pre- and post-thrombectomy CT images with clinical features to accurately predict unfavorable 90-day functional outcomes in acute ischemic stroke patients who exhibit immediate post-procedural cerebral hyperdensity, outperforming standalone models and enhancing physician prognostic accuracy.

Jiahong Fu, Yuhan Chen, YUjie Shen, Jiayi Hong, Shiying Gai, Huan Liu, Yan Li, Lina Jiang, Xiaochao Yu, Dekuai Tong, Son (…)2026-07-14