3760 papers
Rationally designed short hybrid peptide Cec-Aur 1 demonstrates potent, low-toxicity anti-MRSA and anti-biofilm activities, including significant synergy with oxacillin and effective wound healing in a murine infection model, positioning it as a promising therapeutic candidate against multidrug-resistant *Staphylococcus aureus*.
This prospective comparative study demonstrates that a personalized dual-threshold bolus tracking protocol significantly improves venous image quality and diagnostic yield in one-stop lower extremity CTA-CTV compared to a fixed-delay approach, while maintaining equivalent arterial enhancement and radiation dose.
This retrospective study of 361 orthodontic patients aged 8 to 18 found that molar incisor hypomineralisation (MIH) has a 24.9% prevalence and is strongly associated with hypomineralisation in other permanent teeth and enamel hypoplasia, highlighting the need for early monitoring of non-index teeth in affected children.
Using 2022 Household Income and Expenditure Survey data, this study reveals that chronic illness and Out-of-Pocket healthcare spending in urban Bangladesh create a vicious cycle where households are significantly more likely to fall into poverty due to medical costs, while poverty simultaneously increases the risk of chronic illness.
This multi-database cohort study demonstrates that specific postoperative antibiotic trajectories, particularly persistent broad-spectrum therapy and late escalation, are reproducible prognostic markers of increased in-hospital mortality in cardiopulmonary bypass patients, outperforming conventional binary exposure definitions.
This cross-sectional study of 841 patients with chronic total occlusion reveals that cholesterol–high-density lipoprotein–glucose (CHG) modified anthropometric indices, particularly CHG-ABSI and CHG-WWI, are strongly and independently associated with poor collateral circulation formation, outperforming the CHG index alone in identifying patients with an adverse metabolic-adiposity phenotype.
This study characterizes the molecular spectrum and genotype-phenotype correlations in 162 Romanian patients with neurofibromatosis type 1, revealing 17 novel variants, significant phenotypic variability even among individuals with identical genotypes, and the importance of comprehensive genomic testing for identifying dual diagnoses and guiding multidisciplinary surveillance.
This cross-sectional study of 565 medical students in North India reveals a significant gap between their high awareness of healthy lifestyle importance and their actual practices, with time constraints and low motivation identified as primary barriers to behavior adoption.
The CAPA-CITY 70 pilot study demonstrates that a primary care-based, supervised adapted physical activity program is feasible and highly acceptable for community-dwelling adults aged 70 and older with chronic conditions, achieving high completion and adherence rates while supporting the need for larger controlled trials to assess long-term effectiveness.
This two-center retrospective study of 108 patients demonstrates that catheter-induced flow compromise, driven primarily by vertebral artery tortuosity and including both complete wedges and incomplete flow stasis, is a strong independent predictor of multiple new ischemic lesions following endovascular treatment of posterior circulation aneurysms, underscoring the need for rigorous preoperative anatomical assessment and intraprocedural risk-avoidance strategies.