3760 papers
This retrospective cohort study of 50 SLE patients presenting to the emergency department found that while immunological markers and complement depletion are associated with severe disease, the clinical severity of the presentation itself is the strongest predictor of ICU admission and mortality.
This case report describes a rare instance of Pneumocystis jirovecii pneumonia in an immunocompetent female, suggesting that chronic stress and environmental exposure may impair local pulmonary immunity and predispose individuals with normal immune function to the infection.
This retrospective study utilized Gaussian Mixture Modeling on the first 72 hours of multidimensional physiological data from 3,493 surgical ICU patients to identify five distinct trajectory phenotypes that reveal clinically meaningful subgroups with varying disease severity and resource utilization patterns, including a unique high-risk, zero-mortality group characterized by advanced age and compensated physiology.
This study developed and externally validated a dual-phase multimodal Transformer model that integrates pre- and post-thrombectomy CT images with clinical features to accurately predict unfavorable 90-day functional outcomes in acute ischemic stroke patients who exhibit immediate post-procedural cerebral hyperdensity, outperforming standalone models and enhancing physician prognostic accuracy.
This study demonstrates that while a single follow-up CT scan is as effective as longitudinal growth metrics for identifying invasive lung adenocarcinoma in subsolid nodules, annualized mass growth remains a critical independent predictor of invasion even in lesions that have not yet developed an overt solid component.
This single-center Chinese study demonstrates the feasibility and safety of implementing a COG-based pathway for newly diagnosed high-risk neuroblastoma followed by dinutuximab beta maintenance, reporting a 3-year event-free survival of 69.2% with manageable toxicity profiles and highlighting the importance of cycle-stratified safety analysis and monitoring for CNS-related relapses.
This study demonstrates that in patients with cerebral small vessel disease, a higher burden of white matter hyperintensities is associated with altered functional network topology characterized by increased local segregation and enhanced structural-functional coupling, suggesting that white matter injury drives brain network reorganization and may serve as a key imaging marker for disease severity.
This 12-year longitudinal study of cognitively unimpaired Parkinson's disease patients reveals that excessive daytime sleepiness is a significant predictor of accelerated cognitive decline and an increased risk of conversion to dementia, independent of other clinical factors.
This retrospective study of 190 acute pancreatitis patients demonstrates that a 48-hour procalcitonin (PCT) level exceeding 0.23 ng/mL is a superior independent predictor of pancreatic necrosis compared to traditional scoring systems and other biomarkers, offering a rapid and effective tool for early clinical identification.
This retrospective cohort study of 205 maintenance hemodialysis patients demonstrates that aortic arch calcification scores derived from routine chest CT scans are independent predictors of both cardiovascular and all-cause mortality, offering a promising tool for risk stratification in this population.