📄 Category

medicine

13805 papers

📄 medicine

Systemic Immune Reprogramming After Tumor Resection: Perioperative Changes in Chemokines and Immune Checkpoint Markers in Oral Squamous Cell Carcinoma

This study demonstrates that oral squamous cell carcinoma drives coordinated systemic immune activation characterized by elevated chemokines and immune checkpoint markers, which rapidly normalize within the first week following tumor resection, suggesting the potential of perioperative immune dynamics and composite signatures as non-invasive tools for disease detection and monitoring.

Miriam Kokal-Ribaudo, Niclas Rénevier, Juliana Sufcak, Xiangyuan Wu, Ole Moritz Block, Katharina Besch, Christina Bäcker (…)2026-10-16
📄 medicine

Intentional External Scaffolding and Friction as a Novel Non-Pharmacological Behavioral Framework for Executive Dysfunction and Metabolic Health in Late-Diagnosed Neurodivergent Adults

This paper presents a novel theoretical framework and clinical protocol called the Strength Protocol Program, which utilizes intentional external scaffolding and friction to address executive dysfunction and metabolic health in late-diagnosed neurodivergent adults with obesity, though it currently offers only a theoretical description without reported efficacy data.

Dylan Kratochvil2026-10-16
📄 medicine

Mediating role of the Dietary Index for Gut Microbiota in the association between depression and cardiovascular health among US adults

Using data from 18,071 US adults, this study demonstrates that depressive symptoms are negatively associated with cardiovascular health (Life's Essential 8) and that the Dietary Index for Gut Microbiota partially mediates this relationship, particularly among women and individuals with gastrointestinal diseases.

Shupeng Jiang, Zixuan Zhang, Jiji Zhu, Mengmeng Ji, Luying Jiang, Shilang Fan, Houjuan Zuo2026-10-16
📄 medicine

Gut Microbiota-Derived Hexanoic Acid Mediates the Protective Effects of Electroacupuncture Against Sepsis Through Macrophage Reprogramming

This study demonstrates that electroacupuncture alleviates sepsis-induced liver injury by remodeling the gut microbiota to increase *Lactobacillus vaginalis*-derived hexanoic acid, which suppresses pro-inflammatory macrophage polarization via BMAL1/NF-κB signaling, and further enhances therapeutic efficacy through an INT-777-functionalized pH-responsive liposomal delivery system.

Shifan Yan, Zehong Liu, Jun Xiong, Daocheng Zhu, Li Chen, Yu Jiang, Ting Yu2026-10-16
📄 medicine

Effects of intermittent pinpoint thermal stimulation using electronic moxibustion on cardiovascular responses: a randomized crossover study

This randomized crossover study demonstrates that intermittent pinpoint thermal stimulation at the Zusanli acupoint sustains a reduction in heart rate in healthy individuals, whereas continuous stimulation produces only a transient effect, highlighting the critical influence of temporal stimulation patterns on cardiovascular responses.

Kojirou Ito, Hidehiro Nakahara2026-10-16
📄 medicine

Effect of orthodontic treatment on systemic inflammatory biomarkers in patients with malocclusion: A Systematic Review of Randomized Controlled Trials

This systematic review of three randomized controlled trials concludes that orthodontic treatment induces a transient, self-limiting local inflammatory response in gingival crevicular fluid without a dose-dependent relationship to force magnitude, but it fails to determine effects on systemic inflammation due to the absence of studies measuring circulating biomarkers.

Fahad Aziz Khattak, Sana Ali Khan, Muhammad Usman Afridi, Aaeyla Wasif, Mahad Azhar2026-10-16
📄 medicine

Evaluating Sodium Guideline Limits in Saudi Arabia: A Distribution-Based Analysis Using the Saudi Food Composition Database

This study utilized a distribution-based analysis of the Saudi Food Composition Database to evaluate the feasibility of the sodium limits in GSO 2612:2025, revealing that a significant proportion of foods in various categories already meet or fall below these guidelines, thereby supporting the potential for stricter sodium reduction targets.

Omar Alhumaidan, Ghadir Fallata, Shihana Alakeel, Sarah Alkhunein, Mohammed Alsaif2026-10-16
📄 medicine

Prevalence Severity and Determinants of Potential Drug–Drug Interactions among Hospital Prescriptions at Dongola Specialized Hospital Sudan 2025

A 2025 cross-sectional study at Dongola Teaching Hospital in Sudan found that 37.5% of prescriptions contained potential drug–drug interactions, predominantly pharmacodynamic and involving cardiovascular agents, with older age, polypharmacy, and chronic diseases identified as significant predictors.

Kamal A. A. Mohammed, Roaa Ebrahim Bashir Taha, Thoraya Salah Murtada Sidahmed, Anas Mohamed Ibrahim Mohamedelkhair, Doh (…)2026-10-16
📄 medicine

The role of spirituality and religiosity on the suicide ideation and depressive symptoms of middle to old age Brazilian homeless individuals

This cross-sectional study of 162 middle-to-old-aged homeless individuals in São Paulo, Brazil, reveals that while positive spiritual and religious factors (such as intrinsic religiosity, spiritual well-being, and positive coping) are associated with reduced depressive symptoms and suicidal ideation, negative spiritual coping is linked to worse mental health outcomes, highlighting the need to integrate spiritual dimensions into public health interventions for this vulnerable population.

LUCIANO VITORINO, Ravan Abner Rosa, Flávio Teixeira Carvalho, Cloe de Oliveira Massa, Ana Carolina Scurato Testa, Mário (…)2026-10-16
📄 medicine

Two Indicators, a Common Trend: Scabicide Dispensing and Search Volume as Indirect Proxies for Scabies in Spain (2021–2025)

This study demonstrates that scabicide dispensing and Google search volume serve as complementary, seasonally correlated indirect proxies for monitoring scabies trends in Spain from 2021 to 2025, revealing an overall increase in burden followed by a potential early decline in 2025 and a shift toward increased ivermectin use.

Inigo Navarro-Fernandez, Angel Fernandez-Camporro, Pedro Arcos-González2026-10-16