3760 papers
This study demonstrates that newly synthesized coumarin-piperazine derivatives, particularly compound 4s, effectively alleviate inflammatory bowel disease by inhibiting the NF-κB pathway to reduce IL-6 expression, thereby mitigating intestinal inflammation with low toxicity.
This study utilized real-world databases (FAERS and JADER) to detect significant escitalopram-related suicide risk signals, identified serotonergic and dopaminergic pathways as underlying molecular mechanisms, and demonstrated that machine learning models for predicting adverse events require region-specific retraining to maintain accuracy across different populations.
A Data Envelopment Analysis of 12 secondary-level hospitals in Ethiopia reveals widespread technical and scale inefficiencies, indicating that these facilities could reduce inputs by 34% and increase outputs by 85% without compromising service levels, potentially saving 192.5 million ETB through targeted improvements in human resources and medical supply management.
This paper synthesizes current evidence on the pathogenesis and clinical features of filamentary keratitis associated with Sjogren's syndrome, presenting case examples to argue that ophthalmologists should screen patients with refractory or severe filamentary keratitis for Sjogren's syndrome to facilitate earlier systemic diagnosis and improve outcomes.
This systematic review of 13 studies concludes that nurse- and midwife-led lactation counseling, particularly when delivered as multimodal interventions combining antenatal and postnatal support with peer or digital elements, significantly increases exclusive breastfeeding rates and improves maternal outcomes.
This biomarker-driven phase II trial demonstrates that baseline Wilms tumor gene 1 (WT1)-specific cytotoxic T lymphocyte frequency is a strong predictor of durable clinical outcomes in pediatric patients with high-risk solid tumors receiving WT1-targeted immunotherapy, while also identifying specific immune signatures as candidate biomarkers for early response prediction.
This study analyzes 2024 Demographic and Health Survey data to reveal that cervical cancer screening prevalence remains low (under one-third) among women aged 15–49 in Malawi and Zambia, with uptake significantly influenced by age, socioeconomic status, HIV status, and access to health services, highlighting the urgent need for targeted interventions to address these disparities.
This study of 157 diabetic patients reveals that while regular healthcare follow-ups significantly aid lifestyle adherence, the high cost of recommended foods remains a major barrier, necessitating targeted educational campaigns and strengthened patient monitoring to improve overall regimen compliance.
This study utilizing UK Biobank data reveals that elevated serum γ-glutamyl transferase (GGT) levels are positively associated with an increased risk of breast cancer, demonstrating a significant gene-environment interaction with genetic risk and supporting a potential causal relationship through Mendelian randomization analysis.
This study demonstrates that in patients with degenerative cervical myelopathy, long-term neurological and functional outcomes are primarily determined by baseline preoperative neurological status rather than the magnitude of postoperative improvement, underscoring the critical importance of early surgical intervention.