13805 papers
This study demonstrates that Mas receptor signaling is essential for normal spermatogenesis and that its pharmacological activation with AVE0991 offers partial protection against testicular injury and sperm dysfunction in a diabetic mouse model, although the underlying mechanism and receptor dependence in this context remain incompletely defined.
In a prospective observational study of 221 women with intrahepatic cholestasis of pregnancy in India, late-pregnancy serum bile acid concentrations were generally not significantly associated with adverse maternal or neonatal outcomes, although a single finding of lower mean 5-minute Apgar scores in the highest bile acid group was not clinically significant and the study was limited by a small sample size of severe cases.
This study reveals that adrenal metastases constitute a distinct immune compartment enriched with activated, tissue-resident PD-1+ T cells that undergo unique clonotypic remodeling, rendering them resistant to PD-1 blockade despite an effector phenotype.
Pre-clinical trials in Burkina Faso demonstrate that a novel long-acting injectable ivermectin formulation (mdc-STM-001) administered to cattle at a 1.0 mg/kg dose effectively kills Greater Mekong Subregion malaria vectors for up to 112 days, supporting its further evaluation for human use to aid malaria elimination efforts.
This prospective cohort study of 1,660 adults from the Hoveyzeh Cohort Study identified two distinct cardiometabolic risk profiles using latent class analysis but found that membership in the high-risk profile was not significantly associated with an increased risk of developing incident dyslipidemia over a five-year follow-up.
Through a realist evaluation of the Better Health at Work Award in North East England, this study identifies seven key interrelated factors—ranging from leadership commitment to inclusive culture—that determine the success of workplace health initiatives, ultimately refining a programme theory to guide the design of sustainable, context-sensitive interventions.
This systematic review of twelve studies finds that while detecting coronary artery calcification during lung cancer screening is associated with increased cardiovascular preventive actions in some cases, reporting alone does not consistently translate into downstream clinical management, highlighting the need for structured follow-up pathways to improve patient outcomes.
This cross-sectional study conducted in Kumasi, Ghana, reveals that while people living with chronic kidney disease, their caregivers, and the general population possess adequate knowledge of kidney transplantation, they exhibit poor attitudes and perceptions toward the procedure, highlighting an urgent need for targeted interventions to address these psychosocial barriers.
This case report describes a patient with suspected glycogen storage myopathy who experienced significant clinical improvement in muscle weakness and metabolic parameters after three months of empagliflozin treatment, suggesting a potential therapeutic role for the drug that warrants further investigation.
This study validates that atypical neurodegenerative disease variants are not statistical outliers but rather topographically determined systemic states reflecting inherent CNS vulnerability, demonstrating that a novel protein-agnostic network model (OPC) successfully resolves the topographical mismatches found in conventional cohort-based staging by revealing strong positive correlations with established proteinopathy patterns.