13805 papers
This study identifies the PIK3CA p.H1047R mutation as a potential predictive biomarker for resistance to neoadjuvant chemotherapy in hormone receptor-positive locally advanced breast cancer, while noting the absence of ESR1 mutations in this setting compared to metastatic cases.
This study synthesizes qualitative data from 12 Community Insight Profile reports in Oxfordshire to identify recurring barriers to health and social well-being—such as cost-of-living pressures, housing issues, and service access gaps—while highlighting local community assets to inform more equitable, place-based action on health inequalities.
This study developed and validated a simple two-variable nomogram based on age and baseline fast-twitch muscle amplitude that effectively predicts the electrophysiological response to postpartum pelvic floor rehabilitation, demonstrating moderate temporal robustness and performance comparable to complex machine learning models.
This study reveals a 29.1% prevalence of *Helicobacter pylori* infection among young adults aged 18–25 and demonstrates that a support vector machine (SVM) model, utilizing factors such as family size and testing history, effectively predicts infection risk for large-scale screening.
This qualitative study of engaged couples in northern Iran reveals that their sexual and reproductive health education needs extend beyond basic biological information to include relationship skills and communication, highlighting a critical mismatch with current practices and calling for interactive, multi-channel, and culturally sensitive educational approaches.
This multicenter cross-sectional study in Madagascar's SAVA Region found that perceived stress, anxiety, and anxiety-depressive disorders are independently associated with a history of cardiovascular events among adults with hypertension, even after adjusting for traditional risk factors.
This qualitative study found that head, neck, and lung cancer survivors, despite lacking prior knowledge of transcranial magnetic stimulation (TMS), expressed strong willingness to use it for smoking cessation after brief education, citing its non-invasive nature and medication-free approach as key benefits while identifying treatment duration as a primary barrier.
This five-year retrospective study demonstrates that combining iStent inject W® with phacoemulsification provides sustained intraocular pressure reduction, durable medication burden reduction, and long-term structural stability in patients with ocular hypertension or primary open-angle glaucoma, supporting its effectiveness as a long-term management strategy.
This study on healthy young adults in Nepal reveals that while baseline blood pressure is lower in summer than in winter, the blood pressure reactivity to cold pressor and handgrip stress tests is significantly heightened during the summer season, indicating a distinct seasonal modulation of cardiovascular stress responses.
This study establishes a scalable, animal-free *Pichia pastoris* platform that successfully produces a highly pure, high-yield recombinant variant of the *Plasmodium falciparum* circumsporozoite protein (PfaCSP0002) with enhanced stability and immunogenicity compared to full-length variants, laying the groundwork for GMP-compliant vaccine development.