13805 papers
This study demonstrates that chronic Flunitrazepam administration impairs male reproductive function in Wistar rats by disrupting the pituitary-gonadal axis, inducing oxidative stress, and causing histological testicular damage.
This in vitro study demonstrates that while resin cement initially offers superior retention for 3D-printed crowns on primary anterior teeth compared to resin-modified glass ionomer cement regardless of preparation height, thermal aging significantly reduces this advantage, suggesting that cement selection is more critical than preparation height for initial retention.
This study utilized geographically weighted Cox regression on 52,217 tuberculosis patients in Central Java, Indonesia, to demonstrate that the associations between patient characteristics (such as HIV status, age, and comorbidities) and mortality risk vary significantly across geographic locations, suggesting that global models may overlook critical local heterogeneities in healthcare outcomes.
This case report describes a rare instance of malnutrition-associated reversible splenial lesion syndrome (RESLES) in a 14-year-old female following sleeve gastrectomy, characterized by severe electrolyte disturbances and acute kidney injury that resolved completely with intensive supportive care and nutritional correction.
This case-control study in Cameroon reveals that malaria and typhoid fever co-infection significantly elevates physiological stress (cortisol) and oxidative damage while depleting antioxidant defenses and altering cytokine profiles, identifying cortisol, IL-4, IL-10, and TNF-α as promising diagnostic biomarkers for distinguishing these infections among febrile patients.
This prospective case-control study found that while maternal serum sFlt-1, PlGF, and the sFlt-1/PlGF ratio levels differ significantly between women with placenta accreta spectrum and controls, the ratio's diagnostic utility is limited as it loses independent association with the condition after adjusting for clinical risk factors, despite showing a correlation between circulating and placental tissue PlGF expression.
This narrative synthesis proposes that flumazenil and BPC-157 act on complementary mechanisms to reverse benzodiazepine tolerance by respectively restoring GABA-A receptor coupling and mitigating downstream neuroinflammatory and tissue repair deficits, warranting further controlled clinical investigation into their combined use.
This case report describes a fatal cardiorespiratory arrest occurring during the initial rituximab infusion in a patient with refractory chronic inflammatory demyelinating polyradiculoneuropathy, highlighting the critical need for continuous monitoring and immediate resuscitation capabilities when administering this off-label therapy.
This prospective multi-center study by the Fetal Heart Society Research Collaborative found that fetal ventricular longitudinal strain does not predict postnatal hypoxemia or the need for balloon atrial septostomy in neonates with D-transposition of the great arteries and an intact ventricular septum, underscoring the necessity of preparing for septostomy during delivery planning for all such cases.
This retrospective cohort study of 76 women found that prosthetic material exposure occurred in 22.4% of patients following Remeex system implantation for stress urinary incontinence, with vaginal hysterectomy and contaminated preoperative urine cultures identified as significant risk factors.