3901 papers
This retrospective study of 104 invasive lobular carcinoma cases reveals that neoadjuvant systemic therapy yields limited pathological response and fails to significantly increase breast-conserving treatment rates compared to primary surgery, highlighting the challenges of managing ILC's distinct biological features.
This cross-sectional study of over 52,000 Chinese women demonstrates that higher TyG index and TG/HDL-C ratio levels are independently and positively associated with hypertension, exhibiting non-linear dose-response relationships with identified clinical thresholds of TyG > 8.0 and TG/HDL-C > 1.4 that could serve as effective, low-cost screening tools for early risk identification.
This cross-sectional study developed and validated a feasible Intrinsic Capacity Index (ICI) based on the WHO ICOPE framework, demonstrating that lower ICI scores in community-dwelling older adults are significantly associated with adverse geriatric outcomes such as frailty, functional dependence, and polypharmacy.
This cross-sectional study of 365 medical undergraduates in Delhi NCR reveals that while students exhibit moderate knowledge, neutral attitudes, and growing engagement with AI tools like ChatGPT, significant gaps in formal training and practical competency persist, underscoring the urgent need for structured curricular integration of AI literacy and ethics in medical education.
This study developed a Multilayer Perceptron neural network model using MIMIC-IV data that outperforms logistic regression and XGBoost in predicting early sepsis-induced immunosuppression, achieving an AUC of 0.82 and identifying key risk factors to facilitate precision treatment.
This pre-post intervention study demonstrates that a medical consortium-based continuing medical education program significantly enhanced COPD-related knowledge and clinical skills among 296 primary care physicians in Jinjiang District, Chengdu, validating its potential as a scalable model for strengthening chronic respiratory disease management in primary care.
This study utilizes integrated in vivo optical coherence tomography and untargeted metabolomics in a rabbit model to identify specific metabolic dysregulations, including altered levels of 11 key metabolites and their interaction with the Slc5a7 receptor, that underlie the progression of in-stent neoatherosclerosis.
This randomized clinical trial demonstrates that microbiota transplant therapy is safe and effectively improves gastrointestinal symptoms and behavioral outcomes in children with Pitt-Hopkins syndrome by remodeling the gut microbiome and enhancing mitochondrial function.
This cross-sectional study of 563 healthcare professionals in Beira City, Mozambique, reveals that while the majority hold favorable attitudes toward Mpox, knowledge levels are moderate and significantly influenced by age, education, professional role, and access to multiple information sources, highlighting the need for targeted training and improved surveillance integration.
This study characterizes the molecular profiles and antimicrobial resistance patterns of uropathogenic bacteria isolated from elderly nursing home residents in Accra, Ghana, revealing a high prevalence of multidrug-resistant Gram-negative pathogens, particularly *E. coli* and *K. pneumoniae*, carrying diverse virulence and ESBL genes.