📄 Category

medicine

3901 papers

📄 medicine

National Emergency Routine Immunization Coordinating Centre an emergency response to address routine immunization gaps in Nigeria: a mixed-method retrospective study

This mixed-method retrospective study demonstrates that the establishment of Nigeria's National Emergency Routine Immunization Coordination Center (NERICC) significantly improved routine immunization coverage, evidenced by a 51% increase in average Penta3 coverage across prioritized states between 2016 and 2021, highlighting the critical role of coordinated, evidence-based interventions in strengthening health systems.

Ahmed-Rufai Garba, Daniel Ali, Festus Umaru, Pius Angioha, Sulaiman Etamesor, Belinda Uba, Hadiza Hussayn Jibril, Grace (…)2026-07-15
📄 medicine

Joint Effect of Rapid Kidney Function Decline and Depressive Symptom Trajectories on New-onset Stroke: A Prospective Study Based on the CHARLS Cohort

This prospective study of 5,452 Chinese adults demonstrates that the concurrent presence of rapid kidney function decline and increasing depressive symptoms exerts a significant synergistic effect on the risk of new-onset stroke, highlighting the value of dynamic monitoring of both renal and psychological trajectories for improved stroke prevention.

Rongyong Man, Bin Wu, Xianbi Tang, Li Liu, Xi Shao, Kaifa Peng, Yushi Zhong, Kun Wu, Yilin Feng2026-07-15
📄 medicine

Smoking Patterns, Trust in Information Sources, and Beliefs About ENDS as a Smoking Cessation Aid: A Cross-Sectional Analysis of HINTS 7

This cross-sectional analysis of HINTS 7 data reveals that while current ENDS use, female gender, younger age, and high trust in scientists and family members are associated with the belief that ENDS aid smoking cessation, this belief does not significantly motivate quitting intentions among current combustible cigarette smokers.

Yu Liu, Ya-Chen Tina Shih2026-07-15
📄 medicine

Deciphering Liver-Kidney Meridian Tropism and Shared Molecular Modules of Antitumor Herbal Medicines in Ovarian, Cervical, and Bladder Cancers

This study elucidates the molecular basis for the Traditional Chinese Medicine principle of "same treatment for different diseases" in ovarian, cervical, and bladder cancers by demonstrating that liver-kidney meridian-associated herbal compounds, particularly β-sitosterol and quercetin, converge on shared hub targets (AKT1, MYC, TP53, EGF, MMP9) and the PI3K-Akt pathway to regulate tumor progression and drug resistance.

Sheng Zhang, Tian Zhang, Xiuxiu Zhu2026-07-15
📄 medicine

Perioperative outcomes for children with preoperative upper respiratory tract infection symptoms in elective non-cardiac surgery after COVID-19 pandemic at a large tertiary hospital in China: a retrospective cohort study

This retrospective cohort study of children undergoing elective non-cardiac surgery in China found that while preoperative upper respiratory tract infection symptoms were associated with increased emergence respiratory adverse events and longer PACU stays in the post-COVID-19 era, these risks were not significantly elevated in the pre-pandera period, suggesting that the impact of URTI on perioperative outcomes is modulated by the temporal context of the pandemic.

Ruochen Pan, Yuan Bi, Tianqing Yan, Jianbo Deng, Zhang Tian, Zitong Zhang, Aijun Xu2026-07-15
📄 medicine

Three Thiol-Reactive Reagents drive Synergistic Lethality in Glioblastoma cells

This study demonstrates that a synergistic triple-combination of thiol-reactive reagents (acrylamide, auranofin, and buthionine sulfoximine) effectively induces lethal oxidative stress and cell death in glioblastoma cells by disrupting redox signaling pathways while sparing primary neuronal cultures, offering a promising therapeutic strategy for treating glioblastoma.

Ofer y Kashi, Adi Cohen, Kathleen Earhart, Jonathan David Elliot, MO Ramirez Denise, Sukanya Rauniyar, Ghazi Qureshi, Ga (…)2026-07-15
📄 medicine

Development and external validation of a laboratory-free clinical decision-support model for sepsis prediction at emergency department triage: a retrospective cohort study

This retrospective cohort study developed and externally validated a laboratory-free, nurse-assessable sepsis prediction model using XGBoost that demonstrated strong internal performance but poor external generalizability, suggesting that a simplified five-variable version may offer better cross-institutional transportability for emergency department triage despite requiring further prospective validation.

Chao Ding, Qingjiang Lyu2026-07-15
📄 medicine

Patterns of musculoskeletal disorders among Cameroonian healthcare workers and their associations with physical activity, sedentary behavior, and health-related quality of life

This cross-sectional study of Cameroonian healthcare workers reveals a high prevalence of musculoskeletal disorders, particularly in the lower back and neck, which are significantly associated with factors such as age, occupation, sedentary behavior, and poor physical health-related quality of life, while moderate physical activity serves as a protective factor.

Jerson Mekoulou Ndongo, William Mbang Bian, . Ahmadou, Ange Ulrich Le Roy Tabunguia, Hassane Ahmet Malam Moussa, Emmanue (…)2026-07-14
📄 medicine

Scalable generation of polyfunctional therapeutic virus-specific T cells with tissue-homing features and resident-memory-like plasticity across viral targets

This study establishes a rapid, scalable, and GMP-compatible 10-day manufacturing platform that generates highly specific, polyfunctional, and allogeneic virus-specific T cells with tissue-homing features and resident-memory-like plasticity, effectively overcoming precursor frequency limitations for treating refractory viral infections.

Francesc Rudilla, Rut Mora-Buch, Emma Enrich, Alexia Gonzalez-Sevilla, Maria Tomás-Marín, Miriam García Bosca, Mireia An (…)2026-07-14
📄 medicine

Impact of different physical examination frequencies on biochemical indicator variability in community-dwelling older adults: an 8-year retrospective cohort study

This 8-year retrospective cohort study of over 57,000 older adults in Shanghai reveals that while higher frequencies of health examinations are significantly associated with improved long-term trajectories for renal and hepatic function and LDL cholesterol, they are paradoxically linked to faster increases in BMI and triglycerides, suggesting that regular monitoring must be integrated with lifestyle interventions for comprehensive health promotion.

Haiyang Zhang, pei Lian, Tingting Wu, Peiyu Xu, Ting Zhou, Junying Yu, Hongkai Tao, Hong Yu2026-07-14