3901 papers
This qualitative study of Australian health professionals reveals that broad consent for future paediatric genomic research is ethically defensible and supported when accompanied by clear explanations, robust safeguards, voluntary participation, and practices that progressively involve children as their decision-making capacity develops.
This study uses a net-benefit threshold model to demonstrate that current randomized evidence fails to show anticoagulation provides a sufficient reduction in recurrent stroke to outweigh bleeding risks compared to antiplatelet therapy for cancer-associated ischemic stroke, thereby supporting the need for a confirmatory trial rather than a change in clinical practice.
This retrospective cohort study of 35 Colombian patients with radioactive iodine-refractory differentiated thyroid cancer demonstrates that tyrosine kinase inhibitors, particularly lenvatinib, provide meaningful disease control and enable surgical resection in the neoadjuvant setting within a real-world clinical practice.
This study characterizes the clinical, pathological, and molecular features of three GLI1-altered mesenchymal tumors, highlighting their distinct histological patterns, nonspecific immunophenotype, and the critical necessity of genetic confirmation for definitive diagnosis and favorable prognosis.
This CDC WONDER analysis of U.S. mortality data from 1999 to 2023 reveals that while age-adjusted death rates from concurrent atherosclerotic heart disease and heart failure initially declined, they recently surged with widening disparities across gender, race, geography, and age groups, particularly alarming increases among younger adults and non-Hispanic Black populations.
This qualitative study of overweight adults in China's Greater Bay Area reveals that despite high health literacy, weight management is hindered by a significant "know-do gap" driven primarily by occupational time poverty and a lack of professional guidance, necessitating a shift from individual education to system-level, AI-augmented collaborative care.
This four-year longitudinal study in Cambodia integrates entomological, serological, and environmental data to demonstrate that *Aedes aegypti* abundance, particularly in urban and wetland landscapes, is significantly associated with dengue incidence with a 0–4 week lag, whereas *Aedes albopictus* shows no such relationship, thereby highlighting the critical role of landscape and climate dynamics in shaping dengue transmission risks.
This retrospective study of 181 diarrheagenic *Escherichia coli* isolates from Kisumu, Kenya (2009–2020) reveals that Enteroaggregative *E. coli* is the predominant pathotype and that over one-third of isolates are multidrug-resistant, with high rates of resistance to first-line drugs like ampicillin and trimethoprim–sulfamethoxazole underscoring the urgent need for improved stewardship and diagnostic-guided therapy.
A prospective cohort study of 4,005 parents demonstrates that the French "Faire bouger les ados" social marketing campaign effectively increased parental support and adolescents' physical activity, with the strongest positive impacts observed among parents who recognized all three broadcast waves compared to those with fewer exposures.
This scoping review reveals that the evidence base for multilingual community health workers addressing preventive care gaps among South Asian immigrants in U.S. Federally Qualified Health Centers is narrow and geographically concentrated, highlighting an urgent need for more diverse research to inform broad programmatic recommendations.