📄 Category

medicine

13805 papers

📄 medicine

Targeted Dried Blood Spot Acylcarnitine and Amino Acid Profiling Reveals a Candidate Metabolic Signature in Pediatric Heart Failure: A Cross-Sectional Case–Control Study

This cross-sectional case–control study utilized targeted dried blood spot metabolomics to identify a candidate metabolic signature in pediatric heart failure characterized by significantly decreased levels of specific acylcarnitines and amino acids, suggesting a myocardial shift away from fatty-acid oxidation and highlighting the potential of a low-cost, non-invasive panel for future diagnostic validation.

Saeideh Abdolahpour, Marzieh Sarikhani, Fatemeh Sayarifard, Maryam Gholami, Mojtaba Gorji, Farzaneh Abbasi, Parastoo Ros (…)2026-10-14
📄 medicine

Stasis Dermatitis with Chronic Eczematous changes in a patient with Heart Failure, Chronic Kidney Disease, and Diabetes Mellitus: A Case Report

This case report describes a 70-year-old man with heart failure, chronic kidney disease, and diabetes mellitus who presented with stasis dermatitis featuring chronic eczematous changes, highlighting how these systemic conditions collectively contribute to lower-limb edema, skin barrier dysfunction, and persistent dermatitis requiring targeted topical therapy.

Santhosh Kumar Tumkur Narayanappa2026-10-14
📄 medicine

Long-term outcomes of sacral neuromodulation for anorectal disorders: a retrospective single- center cohort study

This retrospective single-center cohort study demonstrates that sacral neuromodulation provides sustained long-term treatment success for fecal incontinence over a median follow-up of 7.6 years, while highlighting the need for larger studies to better define outcomes for low anterior resection syndrome and refractory constipation due to limited sample sizes.

David LIU, Florian SECKLER, Simone MANFREDELLI, Cécile BRIGAND, Benoit ROMAIN2026-10-14
📄 medicine

Efficacy of rhBMP-2-loaded self-setting calcium phosphate cement combined with nose ring drain technique in the treatment of gouty tophus with bone defect of the first metatarsophalangeal joint

This retrospective study demonstrates that combining rhBMP-2-loaded self-setting calcium phosphate cement with the nose ring drain technique offers superior clinical outcomes, including faster incision healing, reduced complications, and improved joint function, compared to conventional surgery for treating gouty tophus with bone defects in the first metatarsophalangeal joint.

Zejun Yu, Jiangling Pan, Xiaotian Xiong, Qiang Liu, Songchuan Su, Ting Tong2026-10-14
📄 medicine

User-perceived skin-health benefits of a vented prosthetic suspension system in individuals with transfemoral amputation: a randomized crossover trial

In a randomized crossover trial involving 56 individuals with transfemoral amputation, the novel vented AeroFit prosthetic system was found to significantly improve user-perceived residual limb skin health compared to a non-vented system without compromising activity levels, prosthesis use, or quality of life.

Jóna Valgerður Kristjánsdóttir, Reynir Scheving, Benedikt Þorri Sigurjónsson, Knut Lechler, Thor Fridriksson2026-10-14
📄 medicine

Factors associated with cardiopulmonary exercise capacity changes after anatomical and non-anatomical lung resection: a retrospective cohort study

This retrospective cohort study of 149 patients reveals that while lung resection induces significant changes in cardiopulmonary exercise capacity, the extent of tissue removal does not independently predict the magnitude of these changes, which are instead primarily driven by preoperative baseline values and patient age.

Jianping Ji, Zixiao Wang, Chao Wang, Jian Li, Huaguang Liang2026-10-14
📄 medicine

Clinical Characteristics and Risk Factors of Severe Motor Impairment in Children with Cerebral Palsy in Northwest China (Xinjiang): A Single-Center Retrospective Study

This single-center retrospective study of 818 children with cerebral palsy in Northwest China identifies male sex, birth asphyxia, and MRI abnormalities as independent risk factors for severe motor impairment (GMFCS IV–V), although the resulting predictive model demonstrated limited discrimination.

Yi Ruan, Xinping Luan2026-10-14
📄 medicine

Vessel Wall MRI of Chronic Internal Carotid Artery Occlusion: Imaging Findings Associated with Recurrent Stroke

This retrospective study of 188 patients with chronic internal carotid artery occlusion identifies left-sided lesions, hyperintensity in the distal occluded vessel lumen, and poor ipsilateral posterior communicating artery collateral flow as independent vessel wall MRI predictors of recurrent stroke.

Min Tang, Ling Li, Niane Ma, Jun Hu, Xin Zhang, Xuejiao Yan, Yu Wen, Xiaoyan Lei, Xiaoling Zhang2026-10-14
📄 medicine

PSA Trends and Clinical Outcomes Following Radiotherapy Combined with Androgen Deprivation Therapy for Prostate Cancer: A Single-Centre Retrospective Cohort Study from Saudi Arabia

This single-centre retrospective study from Saudi Arabia demonstrates that combined radiotherapy and androgen deprivation therapy yields rapid, deep, and durable PSA suppression with low toxicity and recurrence rates in patients with intermediate- to high-risk prostate cancer, establishing effective real-world benchmarks for this underrepresented regional population.

Mohammed alkhamees, Ahmed Nazer, Ahmed alasker, Zeyad alkhenaizan, Waleed alhejaili, Muhannad alhabshan, Mohammed alkath (…)2026-10-14
📄 medicine

Postoperative PICU Utilisation Following Paediatric Oncology Surgery: National Trends Across Two Policy Eras in England (2008-2022)

This national retrospective cohort study reveals that postoperative paediatric oncology PICU admissions in England significantly increased in volume and resource intensity between 2008 and 2022, with a notable rise in vasoactive support usage despite stable mortality rates across two distinct policy eras.

Rowan Wilson, Aleksandra Nowak, Rebecca A Ward, Matthew R Solomons, Jack C Barton, Amber E Corrigan, Jonathan Round2026-10-14