13805 papers
This study demonstrates that a tumor-agnostic, multimodal cell-free DNA framework integrating genomic, copy-number, and fragmentomic features significantly improves detection and enables accurate longitudinal disease monitoring and mortality risk prediction in esophageal adenocarcinoma patients.
This study demonstrates that limbic vulnerability is a distinct feature of the REM sleep behaviour disorder phenotype across both prodromal and established Lewy body disease stages, where it correlates with symptom severity, cognitive impairment, and predicts future hallucinations.
This retrospective study of 201 emergency department patients with cardiorenal syndrome found that while a higher blood urea nitrogen-to-albumin ratio (BAR) was associated with the need for early hemodialysis, it did not significantly predict in-hospital mortality or ICU admission and offered no significant prognostic advantage over blood urea nitrogen alone.
This retrospective study of 92 women undergoing hysteroscopy demonstrates that partial airway obstruction frequently precedes oxygen desaturation without concurrent apnea and validates an AI algorithm using digital tracheal auscultation to effectively detect these obstruction events.
This case report describes a 39-year-old woman with Resistance to Thyroid Hormone β (RTHβ) caused by a pathogenic THRB mutation (p.Arg429Gln), whose initial misdiagnosis of thyrotoxicosis led to ineffective antithyroid treatment, underscoring the critical need for genetic testing to confirm RTHβ and guide appropriate management when elevated thyroid hormones coexist with non-suppressed TSH.
This case report describes a fatal instance of toxic epidermal necrolysis-like lupus in a 30-year-old woman who experienced sequential spinal cord, nerve, muscle, and marrow involvement despite reassuring serology and standard immunosuppressive therapy, highlighting the limitations of current disease activity indices and the critical need for clinical vigilance regarding sepsis in profoundly immunosuppressed patients with extensive skin loss.
This multicenter cross-sectional study in Uganda reveals a 54.5% prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) among adults with type 2 diabetes, identifying age, hypertension, obesity, poor glycemic control, and elevated triglycerides as key independent risk factors.
This hospital-based cross-sectional study of 319 tuberculosis cases at a tertiary care centre in central Kerala reveals that extrapulmonary tuberculosis is the predominant form, significantly associated with younger age and female sex, and frequently co-occurs with comorbidities like diabetes and hypertension.
This qualitative study of 24 cancer survivors identifies three key psychological barriers—autonomy threats, distress overload, and shame—that perpetuate smoking through a "Smoking-Distress-Avoidance Cycle," thereby informing the design of tailored mindfulness-based interventions to improve cessation support in oncology settings.
This retrospective study of 15 patients demonstrates that isolated posterior spinal tuberculosis, though rare and often missed on plain radiographs, can be effectively diagnosed using CT and MRI and successfully treated with anti-tuberculosis chemotherapy, with or without surgery, resulting in significant clinical improvement and excellent long-term outcomes without recurrence.