📄 medicine

Community Pharmacies and Malaria Surveillance in an Elimination Setting in Ghana: A Cross-Sectional Study of Infrastructure, Documentation Systems, and Provider Willingness

Although community pharmacies in Ghana's Tema West Municipality possess the necessary physical and digital infrastructure and demonstrate high willingness to participate in malaria surveillance, their immediate readiness is significantly hindered by inconsistent documentation practices and a lack of standardized reporting systems.

Harriet Affran Bonful, Micheal Opoku-Mireku, Hainau Iddrisu, Victoria Anima Fordjour, Colette Santah, Joel J. Idun-Acqua (…)2026-10-22
📄 medicine

Haematoma attenuation on non-contrast CT and blood-count inflammatory ratios in spontaneous intracerebral haemorrhage: A systematic review of prognostic studies

This systematic review of 20 studies involving over 10,000 patients indicates that low haematoma attenuation on non-contrast CT is a moderate-certainty predictor of haematoma expansion, while elevated neutrophil-to-lymphocyte ratios are associated with poor functional outcomes and death, though evidence for other inflammatory markers like MPV remains limited.

Lutfi Fauzi H, Muhammad Yunus Amran2026-10-22
📄 medicine

Dry-season malaria transmission and associated risk factors among urban residents of Jabi Tehnan District, northwest Ethiopia

A community-based cross-sectional study conducted in March 2026 among 335 urban residents of Jabi Tehnan District, Ethiopia, revealed a 17.6% dry-season malaria prevalence driven primarily by farming activities, houses with eave openings, and inadequate preventive knowledge, while highlighting insecticide-treated net utilization as a significant protective factor.

Solomon Yeshanew, Fasil Adugna Kendie, Getnet Atenafu, Endalkachew Nibret2026-10-22
📄 medicine

Quantitative Dixon MRI Fat Fraction Is Associated with Bipolar Bone Loss and Chronic Musculotendinous Degeneration in Anterior Shoulder Instability

This study demonstrates that quantitative Dixon MRI-derived muscle fat fraction is significantly associated with bipolar bone loss, off-track Hill–Sachs lesions, and chronic musculotendinous degeneration in patients with anterior shoulder instability, suggesting its potential as a complementary imaging marker for assessing the severity of both static and dynamic stabilizer abnormalities.

Mariya Yurevna Tumasova, Marat Khudaykulovich Khodjibekov, Mukhayyo Ravshanovna Khayitboeva2026-10-22
📄 medicine

Ultrasound-guided microwave ablation combined with polidocanol versus anhydrous ethanol for benign cystic-solid thyroid nodules: a retrospective comparative study

This retrospective comparative study demonstrates that ultrasound-guided microwave ablation combined with polidocanol achieves nodule volume reduction and cosmetic outcomes comparable to those with anhydrous ethanol for benign cystic-solid thyroid nodules, while significantly reducing the incidence of adverse events.

Fan Zhou, Qian Zhao, Zhengqing Mu, Rui Liu, Changsong Xu, Yue Feng2026-10-22
📄 medicine

Pathogen profiling of inflammatory eye diseases with metagenomic deep sequencing in a tertiary referral center

This study demonstrates that metagenomic deep sequencing (MDS) of intraocular fluid at a tertiary referral center successfully identified a diverse range of infectious pathogens in 26.8% of inflammatory eye disease cases, including seven instances where MDS detected infections that were missed by conventional diagnostic methods.

Joanne Thomas, Kirsten Da Silva, Cindi Chen, Lina Zhong, YuHeng Liu, Thomas Abraham, Danny Yu, Armin Hinterwirth, Sruthi (…)2026-10-22
📄 medicine

Democratising patient and public involvement – A case study from the RELAX (Reducing Levels of AnXiety) randomised clinical trial

This paper presents a case study of the RELAX randomised clinical trial, demonstrating how a democratised, equity-focused Patient and Public Involvement (PPI) strategy—characterized by a diverse advisory group, dedicated service-user researcher support, and flexible collaboration—successfully enhanced trial recruitment, retention, and research quality while empowering participants.

Mary Newburn, Brittannia Volkmer, Nathalie Towner, Yogini Sawjani, Tannice Hemming, Siobhean McCarthy-Perham, Abigail Me (…)2026-10-22
📄 medicine

Age-related changes of blood pressure and heart rate in patients with Parkinson’s disease: Is there any effect of antiparkinsonian drugs?

This 16-year longitudinal study of 32 Parkinson's disease patients reveals that systolic blood pressure gradually declines with disease duration over more than a decade, while heart rate remains stable, with neither trend significantly associated with the use of antiparkinsonian medications or increases in levodopa-equivalent daily doses.

Kazumasa Shindo, Akira Mugikura, Shota Nakamura, Tatsuya Saito, Yuto Morishima, Takanori Hata, Yuki Nakamura, Yosuke Tar (…)2026-10-22
📄 medicine

Objective Measures of Sleep Quality and Associations with Cognition in Assisted Living Residents: Comparison with Community Dwelling Residents.

This study reveals that assisted living residents experience significantly shorter and more disrupted sleep than community-dwelling residents, with actigraphy-derived sleep disruptions showing stronger negative associations with cognitive performance in the assisted living group, while highlighting challenges in applying common sleep measurement techniques to this population.

Shane Magnison-Benoit, Erin Bates, Jenna Naylor, R. Stewart Longman, Jayna Holroyd-Leduc, Willis H. Tsai, Marc J. Poulin2026-10-22
📄 medicine

Evaluation of SIRS, pSOFA, and Phoenix Scores for Sepsis Diagnosis and Prognostic Assessment in Infected Children Admitted to the Pediatric Intensive Care Unit

This study evaluating 401 infected children in the PICU found that while the Phoenix score was the most effective for sepsis identification, both the pSOFA and Phoenix scores demonstrated superior prognostic value for predicting mortality compared to the SIRS criteria, though all three systems showed limited agreement with the clinical reference standard and should not replace comprehensive clinical assessment.

Yuanxiong Zeng, Sheng Lin, Haibo Li, Liangwei Dong, Xianglan Kong, Hailun Cai, Shibiao Wang, Botao Ning2026-10-22