3171 papers
This study demonstrates that LARP1 acts as an oncogenic driver in endometrial cancer by promoting tumor growth and carboplatin resistance through E2F1 regulation, suggesting that targeting LARP1 could suppress tumor progression and enhance chemotherapy sensitivity.
This quantitative study demonstrates that dual-layer spectral CT parameters, particularly in the lower lung lobes, can effectively differentiate idiopathic inflammatory myopathy-associated interstitial lung disease subtypes (ASS-ILD vs. PM/DM-ILD) even when they present with identical radiological patterns.
This study demonstrates that targeted alpha-particle therapy using 213Bi-labeled trastuzumab and cetuximab effectively induces dose-dependent cytotoxicity and DNA damage in bladder cancer cells by exploiting abundant EGFR receptors, suggesting strong potential as a bladder-sparing treatment for patients resistant to standard BCG therapy.
This randomized controlled animal study demonstrates that citrate carbon dots effectively suppress calcium oxalate kidney stone formation and mitigate renal tubular damage in a glyoxylic acid-induced mouse model by reducing serum creatinine and urine oxalate levels while increasing urine citrate.
This study analyzes data from 23 European countries to highlight significant variations in the organization, supervision, competences, and working conditions of family physicians, while identifying manpower shortages as a critical challenge across primary care systems.
This retrospective study of 230 treatment-naive chronic hepatitis B patients demonstrates that long-term entecavir therapy achieves high and durable viral suppression with an excellent safety profile, while identifying higher baseline HBV-DNA levels and lack of response at week 24 as key predictors of partial virological response.
This study demonstrates that integrating mind mapping with digital software-guided surgical planning in oral surgery residency training significantly enhances residents' clinical thinking, operative competency, and overall teaching satisfaction compared to conventional lecture-based or mind mapping-only approaches.
This retrospective cohort study developed and internally validated a nomogram using injury type, liver injury grade, hemoperitoneum, and early blood transfusion to accurately predict the need for operative management in patients with hepatic trauma, though external validation is required before clinical implementation.
This cluster randomized controlled trial in Chile found that the culturally adapted "Yo Sé Lo Que Quiero" program, while ineffective for reducing alcohol use among adolescents in economically vulnerable schools, significantly lowered tobacco and cannabis use, demonstrating the feasibility and selective efficacy of evidence-based prevention in Latin American settings.
This study analyzes 160 head and neck cancer drug trials registered with China's NMPA from 2013 to 2025, revealing a landscape dominated by domestic-sponsored, single-arm Phase II trials of biologics and targeted therapies, while highlighting the need for future efforts to prioritize novel target discovery, integrate traditional Chinese medicine, and strengthen research capacity in stomatology hospitals.