📄 medicine

Cellular senescence changes and their association with brain structure in schizophrenia and major depressive disorder

This study reveals that while both schizophrenia and major depressive disorder are associated with elevated cellular senescence markers (SASP indices), these markers correlate with localized reductions in specific cortical surface areas related to auditory and language processing in schizophrenia rather than with global brain aging.

Naohiro Okada, Johanna Seitz-Holland, Tempei Ikegame, Favour Omileke, Masahiro Kiyota, Eimu Shoji, Shunsuke Mori, Susumu (…)2026-10-14
📄 medicine

Survival of tunneled femoral dialysis catheters: a single center retrospective study

This single-center retrospective study of 126 tunneled femoral hemodialysis catheters found a median survival of 459 days with infection and dysfunction as primary failure modes, supporting their viability as a long-term option for patients with exhausted conventional vascular access.

Dacian Tirinescu, Ioana Roșca, Adam Farkas, Remus Orășan, Crina Rusu, Diana Moldovan, Alina Potra, Maria Țicală, Yuriy M (…)2026-10-14
📄 medicine

Beyond Chronological Age: Comorbidity Burden and Physiological Reserve Determine Survival After a Positive Screening Fecal Occult Blood Test in Older Adults

This study of older Thai adults with positive fecal occult blood tests demonstrates that comorbidity burden and physiological reserve, rather than chronological age, are the primary determinants of survival, suggesting that screening policies should prioritize multidimensional health assessments over age-based cutoffs to optimize colonoscopy utilization.

Chavisa Chearsakul, Uayporn Kaosombatwattana, Unchana Sura-amonrattana2026-10-14
📄 medicine

Resident–faculty differences in global performance scores in otolaryngology workplace-based assessment: a national retrospective observational study

This national retrospective study of Taiwan's otolaryngology workplace-based assessments reveals that residents generally assign slightly lower performance scores than faculty raters, with discrepancies varying significantly by training level and case complexity, suggesting these differences can help identify specific encounters requiring targeted feedback.

Okki Dhona Laksmita, Yi-Jia Chen, Ching-Lin Hsieh, Ya-Hui Wang, Chun-Hou Liao, Mingchih Chen, Jeng-Wen Chen2026-10-14
📄 medicine

First-Trimester Anaemia as an Independent Predictor of Preterm Birth: A Retrospective Cohort Study of 3,683 Singleton Pregnancies at a Tertiary Maternity Centre in Latvia

This retrospective cohort study of 3,683 pregnancies in Latvia demonstrates that first-trimester anaemia is an independent predictor of preterm birth, more than doubling the adjusted odds and showing a clear dose-response relationship, thereby supporting universal early screening and aggressive treatment to improve obstetric outcomes.

Fatma Sadiya, Anna Miskova, Dace Rezeberga2026-10-14
📄 medicine

Clinical Profile, Glycemic Management Practices, and Direct Medical Costs among Hospitalized Diabetic Patients in Ethiopia: A Multicenter Prospective Study

This multicenter prospective study in Ethiopia reveals that hospitalized diabetic patients face a substantial clinical and economic burden, with a median direct medical cost of US$417.27 per admission driven primarily by longer hospital stays, pre-admission medication use, and the development of in-hospital complications.

Yonas Demissie Bahru, Alemseged Beyene Berha, Abdurezak Ahmed, Legese Chelkeba2026-10-14
📄 medicine

Comparison of Endoscopic Ultrasound, Computed Tomography and Magnetic Resonance Imaging for Preoperative Tumor-Size Assessment in Resected Pancreatic Neoplasms

This retrospective study of 60 patients with resected pancreatic malignancies demonstrates that endoscopic ultrasound (EUS) provides more accurate preoperative tumor-size measurements than computed tomography (CT) and comparable accuracy to magnetic resonance imaging (MRI), particularly for tumors smaller than 40 mm.

Chia-Che Wu, Te-Jung Chuang, Jung-Chun Lin, Hsuan-Wei Chen2026-10-14
📄 medicine

A clinical-EUS model for GIST probability in resection-selected gastric subepithelial lesions: development and external validation

This study developed and externally validated a three-variable clinical and endoscopic ultrasound model (incorporating age, fundic location, and muscularis propria origin) that demonstrates moderate discrimination for predicting gastrointestinal stromal tumor probability in gastric subepithelial lesions, though its calibration remains uncertain and it should not be used as the sole basis for clinical management decisions.

Jiahuang Huang, Chong Chen, Fei Li, Dayong Sun, Shuo Yang, Hongqian Tao, Xi Li, Chaohui Liu2026-10-14