📄 medicine

Prognostic Analysis of Iodine-avid Residual Metastatic Lymph Nodes in Differentiated Thyroid Cancer

This study demonstrates that in differentiated thyroid cancer patients with iodine-avid residual metastatic lymph nodes, the number and size of these nodes alongside stimulated thyroglobulin levels are independent predictors of persistent radioactive iodine uptake, enabling the development of a nomogram to forecast functional therapeutic response.

Ruoxin Xu, Qingyuan Jia, Mingxuan Zhao, Qiyong Pan, Caihua Tang2026-10-14
📄 medicine

STOPP/START Criteria in Patients with Type 2 Diabetes Mellitus in Colombia: A Cross-Sectional Study

This cross-sectional study of 434 Colombian patients with Type 2 diabetes mellitus reveals a high prevalence (71.7%) of potentially inappropriate medications and therapeutic omissions, particularly among those with rheumatologic comorbidities, highlighting significant opportunities to improve prescribing quality in this population.

Luis Fernando Valladales-Restrepo, Jacobo Pulido-Beltrán, Mauricio Muñoz-Velez, Marlon Eleazart Tafur-Ramírez, Nicolás G (…)2026-10-14
📄 medicine

Effects of Metformin on Resting-State EEG and Associations with Adaptive Behaviors in Fragile X Syndrome

This study demonstrates that metformin treatment in children with Fragile X Syndrome significantly normalizes resting-state EEG markers of cortical excitation/inhibition balance and brain maturation, with these electrophysiological improvements correlating with enhanced adaptive behaviors.

Sarah Lippé, Rae Buckser, Saeideh Davoudi, Vardan Arutiunian, Inga Sophia Knoth Knoth, Angela Thurman, Anne-Marie Bélang (…)2026-10-14
📄 medicine

Design and Feasibility of a Large Language Model-Based Teaching Pathway for Clinical Pharmacy Practice Competencies

This study demonstrates that an LLM-based teaching pathway utilizing structured prompt frameworks (SPADE and RTF) can effectively simulate authentic clinical pharmacy ward round dialogues and provide formative feedback with scores highly correlated to expert judgments, offering a scalable, low-cost alternative to traditional training despite minor limitations in response stability and systematic score underestimation.

Jizhong Zhang, Yuxuan Zhu, Dengwei Lin, Xiaoting Yang, Shuai Yu, Xin Liu, Nan Wu, Min Zhao2026-10-14
📄 medicine

Thoracoscopic-Guided versus Ultrasound-Guided Thoracic Paravertebral Nerve Block in Uniport Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Trial

This randomized controlled trial demonstrates that thoracoscopic-guided thoracic paravertebral nerve block is noninferior to ultrasound-guided block in analgesic efficacy for uniport video-assisted thoracic surgery patients, while offering significantly shorter procedure times and fewer complications.

Long-fei Zhu, Yi-ju Xie, Ling-min Zhang, Chun-jian Zuo, Yuan-lin Deng, Bin Jiang2026-10-14
📄 medicine

Hydration knowledge, attitudes and practices among people living with an ileostomy: A cross-sectional multinational survey

This multinational cross-sectional survey reveals that dehydration and high-output stomas are prevalent among ileostomates in the UK, Ireland, and Australia, driven by low hydration knowledge, significant barriers to fluid intake, and specific clinical factors, thereby highlighting the urgent need for targeted education and ongoing monitoring.

Niamh Magee, Helen McCarthy, Pauline Douglas, Erika J. Rosbotham, L. Kirsty Pourshahidi, Martin Veysey, Nenad Naumovski (…)2026-10-14
📄 medicine

Mechanism of Action of Biologics Related to Long-term Drug Survival for Plaque Psoriasis: A Retrospective Cohort Study

In a retrospective cohort study of biologic-naïve patients with plaque psoriasis, IL-23 pathway inhibitors demonstrated significantly superior long-term treatment continuation compared to IL-17 inhibitors, identifying the mechanism of action as a key independent factor for durable disease control.

Runa Maeda, Ken Shiraiwa, Ryota Tanaka, Ryosuke Tatsuta, Hiroki Itoh2026-10-14
📄 medicine

Pressure-Controlled versus Volume-Controlled Ventilation in Low-Flow Anesthesia; Intraoperative Respiratory Mechanics and Postoperative Pulmonary Function: A Randomized Controlled Trial

In a randomized controlled trial of low-risk patients undergoing low-flow anesthesia, pressure-controlled ventilation was found to significantly reduce peak inspiratory pressure compared to volume-controlled ventilation while maintaining comparable mean airway pressure, lung compliance, and early postoperative pulmonary function.

Yalvac Mehmet, Ozciftci Serhat, Topcu Hulya, Cam Bulent Meric2026-10-14
📄 medicine

Prevalence and Factors Associated with Electronic Cigarette Use Among Adolescents Attending School in Four African Countries Using Global Youth Tobacco Survey Data from 2015 to 2019

An analysis of 2015–2019 Global Youth Tobacco Survey data from Mauritius, Seychelles, Ghana, and Togo reveals that current e-cigarette use among adolescents is a significant and growing concern driven primarily by product awareness and prior smoking, while protection is associated with smoke-free policies and school-based education.

Jerry Sinyangwe, Wingston Felix Ng’ambi, David Mulenga, Cosmas Zyambo2026-10-14