📄 medicine

Physician perspectives on antimicrobial resistance and stewardship in Nigeria’s private healthcare sector: a cross-sectional survey study

This cross-sectional survey of private-sector physicians in Nigeria reveals that while most are aware of antimicrobial resistance and eager for stewardship training, significant gaps in formal education and structural barriers like limited diagnostics and regulatory issues hinder optimal prescribing practices.

Sarah Pascale Ngassa Detchaptche, Nawal Maredia, Blessing Uche, Nnakelu Eriobu, Cassandra Laurie, Aaya Mahdi, Monica Tal (…)2026-10-22
📄 medicine

Sex matters in children living with HIV: sex differences in virological, immunological and proteomic outcomes in early-treated pediatric HIV

This study of early-treated African children with HIV reveals that females experience faster viral decay and lower immunological progression compared to males, highlighting sex as a significant determinant of pediatric HIV disease trajectories despite limited evidence on reservoir size and adherence differences.

Irati Gastesi, Alvaro Ballesteros, Miquel Serna-Pascual, Nicola Cotugno, Giusseppe Pascucci, Paolo Palma, Mark Cotton, A (…)2026-10-22
📄 medicine

Fibrocartilaginous mesenchymoma of the distal femur with focal MDM2 and CDK4 expression but no MDM2 amplification: a case report

This case report describes a rare fibrocartilaginous mesenchymoma of the distal femur in a 14-year-old boy, highlighting the diagnostic challenge of distinguishing it from low-grade central osteosarcoma due to focal MDM2 and CDK4 expression despite the absence of MDM2 amplification, which was confirmed through integrated morphological and molecular analysis.

Yu Pan, Zhou Wang, Shu-ying Zhang, Xiao-yan Lin, Bei-bei Lv2026-10-22
📄 medicine

Placental transfer of anti-Plasmodium falciparum circumsporozoite protein antibodies: Mother-Newborn pair

This study demonstrates that maternal antibodies against the full-length *Plasmodium falciparum* circumsporozoite protein and specific epitopes are efficiently transferred to newborns in Ghana, suggesting that maternal vaccination could further enhance this protective transfer.

Abebe Muche Belete, Harriet Gamadeku, Daniel Dosoo, Larissa A. Luguterah, Harry A. Danwonno, Bernard Tornyigah, Nicaise (…)2026-10-22
📄 medicine

Medium-Term Outcomes of the VICTO Adjustable Artificial Urinary Sphincter: A Brazilian Real-World Multicentre Study

This Brazilian multicentre study demonstrates that the VICTO adjustable artificial urinary sphincter is a safe and effective treatment for male stress urinary incontinence, achieving a 72% social continence rate and high patient satisfaction with a complication profile comparable to the gold standard.

Flavio Trigo-Rocha, Lebani Bruno, Francisco Kanasiro, Vinicius Gomes de Souza, Luis Gustavo Morato de Toledo2026-10-22
📄 medicine

Effect of radical (chemo)radiotherapy on cardiovascular autonomic function in patients with head and neck cancer: a prospective observational study

This prospective observational study found that while radical (chemo)radiotherapy for head and neck cancer induced some transient changes in heart rate and blood pressure variability, conventional autonomic reflex tests showed no significant deterioration in cardiovascular autonomic function within six months of treatment.

Adil Ahmed Khan, Shivam Kumar, Sweety Gupta, Deepa Joseph, Poorvi Kulshrestha, Prashant Kumar Saini, Ashutosh Kashyap, A (…)2026-10-22
📄 medicine

Low-Dose Perioperative Dexmedetomidine for the Prevention of Postoperative Delirium in Older Adults Undergoing Hip Fracture Surgery: A Randomized, Double-Blind, Placebo-Controlled Trial

This randomized, double-blind, placebo-controlled trial demonstrates that perioperative low-dose dexmedetomidine significantly reduces the incidence, severity, and duration of postoperative delirium while improving analgesia, lowering opioid consumption, and shortening hospital stays in older adults undergoing hip fracture surgery.

Le Van Chung, Ta Duc Luan, Lam Tri Duc2026-10-22
📄 medicine

Subperceptual noisy galvanic vestibular stimulation in bilateral vestibulopathy: a double-blind, sham-controlled crossover pilot study

In a double-blind, sham-controlled crossover pilot study involving 10 patients with bilateral vestibulopathy, subperceptual noisy galvanic vestibular stimulation failed to significantly improve standing balance, gait, or functional mobility, suggesting it is not an effective treatment for this condition.

Matthew J. Bancroft, Harriet O’Neill, Benjamin Jones, Diego Kaski, Mohammad Mahmud2026-10-22
📄 medicine

Transforming Multi-Clinic Naturopathic EHR Data into a Research Database: A Retrospective Feasibility Pilot Study

This retrospective feasibility pilot study demonstrates that a HIPAA-compliant, cloud-based pipeline can successfully aggregate, de-identify, and standardize multi-clinic naturopathic EHR data into a research database capable of characterizing patient populations, extracting treatment patterns, and detecting clinically meaningful longitudinal changes in health outcomes.

Paul Kalnins, Ryan Bradley, Steve Chamberlin, Michelle Simon, Erin Sweet, Carlo Calabrese2026-10-22