3171 papers
This case report demonstrates that pupilloplasty can significantly restore vision and resolve nystagmus in a 10-year-old child with rare complex anterior segment anomalies, including acoria and microcornea, despite the patient's age typically being associated with poor amblyopia treatment outcomes.
In a retrospective cohort study of preterm infants in Bandung, gram-negative sepsis was associated with significantly higher mortality compared to gram-positive sepsis, while rates of necrotizing enterocolitis, bronchopulmonary dysplasia, and intracranial hemorrhage did not differ between the two groups.
Analysis of NHANES data from 1999 to 2018 reveals that while the prevalence of sarcopenic obesity and overall fat mass declined among US adults over two decades, the condition remains significantly associated with elevated all-cause and cause-specific mortality risks compared to non-sarcopenic obesity.
This case report describes a neonate with transient congenital hypothyroidism caused by maternal thyroid-blocking antibodies who was later diagnosed with inherited resistance to thyroid hormone beta (RTHβ), highlighting the diagnostic challenge of distinguishing transient antibody-mediated hypothyroidism from genetic RTHβ in infants born to mothers with concurrent autoimmune thyroid disease and RTHβ.
This community-based cross-sectional survey of 200 adults in Mysuru, Karnataka, reveals a high prevalence of self-medication with analgesics—primarily paracetamol and NSAIDs for headache and fever—characterized by limited awareness of adverse drug effects and a significant need for public health interventions to promote rational medicine use.
This multicenter randomized controlled trial demonstrates that platelet function testing-guided antiplatelet therapy, which switches patients with high on-treatment platelet reactivity from aspirin to alternative agents, significantly reduces high platelet reactivity and major ischemic events within 180 days after ischemic stroke without increasing serious bleeding risks.
This case report describes a rare adult-onset presentation of Hurler syndrome in a 27-year-old woman characterized by hyperprolactinemia, pituitary hyperplasia, and severe pulmonary hypertension, highlighting the diagnostic challenges in resource-limited settings and the importance of clinical recognition for managing multisystemic lysosomal storage disorders.
This mixed-methods study of a five-year empathy curriculum at a UK medical school found that student empathy levels remained stable across all years and the program was highly valued by students, who reported that the training would enhance their future empathic practice while suggesting improvements such as more consistent feedback, evidence-based motivation, increased patient interaction, and better well-being support.
This machine learning-assisted pharmacovigilance study analyzed FDA adverse event reports to characterize the spectrum of fatal toxicities associated with osimertinib and developed a validated risk stratification model (OsimiRisk90) to predict early mortality within 90 days of treatment initiation.
This multicenter study of Chinese children with carbapenem-resistant *Acinetobacter baumannii* infections identifies septic shock and organ dysfunction as key mortality risk factors while demonstrating that sulbactam-durlobactam and cefiderocol exhibit potent in vitro activity against these isolates, with the disk diffusion method proving accurate for susceptibility testing.