13396 papers
This narrative review synthesizes evidence that blocked autophagic flux and unresolved endoplasmic reticulum stress function as a unified, druggable stress network driving T cell apoptosis in sepsis-induced immunosuppression, suggesting that biomarker-stratified interventions targeting this axis could enable precision immunomodulation.
This study demonstrates that plasma cell-free MAP2K1 mutation levels serve as a significant prognostic biomarker for predicting progression and relapse in pediatric MAP2K1-mutated Langerhans cell histiocytosis, offering valuable insights for risk assessment and clinical monitoring.
In patients with mild noncardioembolic acute ischemic stroke, tenecteplase was associated with a more favorable distribution of functional outcomes and reduced early neurological deterioration compared to alteplase, although the difference in favorable functional outcome (mRS 0–1) was not statistically significant after multivariable adjustment.
This case report describes a 79-year-old man with catastrophic antiphospholipid syndrome presenting as renal thrombotic microangiopathy who achieved remission through a rituximab-based regimen and was successfully maintained on aspirin monotherapy for 28 months, suggesting a viable alternative to standard anticoagulation for elderly patients with high bleeding risks.
This case report highlights a rare instance of midgut volvulus caused by Ladd's bands in a young adult with a virgin abdomen, emphasizing the critical diagnostic challenges posed by initial misdiagnoses of gastroenteritis and conflicting CT findings that incorrectly suggested normal bowel rotation despite the presence of a mesenteric whirlpool sign.
This study utilizing CHARLS data demonstrates that correcting for the underreporting of chronic conditions using objective biomarkers reveals a significantly higher burden of multimorbidity among older Chinese adults and uncovers a statistically significant education-related health inequality that is obscured when relying solely on self-reported diagnoses.
In a retrospective cohort study of over 13,000 patients with peripheral artery disease and diabetes, combined treatment with GLP-1 receptor agonists and SGLT2 inhibitors was associated with significantly reduced risks of major adverse limb events, amputations, and all-cause mortality compared to no treatment, with SGLT2 inhibitors also showing similar benefits while GLP-1 receptor agonist monotherapy demonstrated a survival advantage.
This study demonstrates that an expedient metabolic preparation protocol involving simultaneous intravenous insulin and 18F-FDG administration without specific glucose targeting significantly reduces the preparation time for myocardial viability PET imaging by 52% while maintaining image quality comparable to standard protocols.
This in-vitro study utilizing CNC-controlled insertion in synthetic and natural bone demonstrates that increasing the rotational speed from 5 to 25 rpm significantly improves several primary stability indicators, whereas further increasing the speed to 50 rpm yields no additional benefit.
This study demonstrates that olanzapine increases the severity of pulmonary *Staphylococcus aureus* infection in mice by suppressing neutrophil recruitment and activation, an effect that is further exacerbated by concomitant inhaled corticosteroid use and correlates with an increased risk of pneumonia-related deaths in patients.