medicine papers | Gist.Science

Phase II study of pembrolizumab plus nab-paclitaxel in Hormone Receptor–positive, HER2- negative metastatic breast cancer: clinical and molecular insights into response

This phase II study demonstrates that combining pembrolizumab with nab-paclitaxel yields a manageable toxicity profile and clinical efficacy in HR+/HER2- metastatic breast cancer, including in patients previously treated with CDK4/6 inhibitors, while revealing that adaptive immune activation alone is insufficient for response and highlighting the prognostic value of baseline T-cell fraction.

Natalie J. Klar, Judith D. Goldberg, Apoorvi Tyagi, Alessandro Leal, Tsivia Hochman, Barb Barbury, Farbod Darvishian, Ma (…)2026-10-22

📄 medicine

Reported Western, traditional, complementary, and integrative pain-management patterns and later pain severity among Chinese adults with musculoskeletal pain: a prospective CHARLS cohort study

This prospective cohort study of Chinese adults with musculoskeletal pain found that using Western medicine alone or an integrative approach was associated with greater subsequent pain severity compared to no treatment, suggesting these patterns likely reflect a clinically complex, high-burden population rather than indicating treatment ineffectiveness.

Yihao Zhou, Haobo Jiang, Wensi Ouyang, Yi Yu, Shijia Xu, Long Chen, Zhaoyong Li, Shaofeng Yang2026-10-22

📄 medicine

Investigating the relationship between employment after retirement and psychological well-being and depressive symptoms in university retirees

This 2025 cross-sectional study of 350 retirees at Shahid Beheshti University of Medical Sciences found that post-retirement employment is significantly associated with reduced depressive symptoms and increased psychological well-being, suggesting that re-employment opportunities can serve as an effective intervention for promoting mental health in this population.

Mobina Khanaghaii, Yadollah Abolfathi Momtaz, Mohammad Heydari, Masoumeh Sadeghipour Roudsari2026-10-22

📄 medicine

Shared Decision-Making, Dental Visit Satisfaction, and Intention to Return Among Adults in Saudi Arabia: A Cross-Sectional Study

This cross-sectional study of 473 adults in Riyadh, Saudi Arabia, demonstrates that shared decision-making is strongly and positively associated with dental visit satisfaction and the intention to return, highlighting the need to move beyond mere information provision to actively involve patients in treatment decisions to enhance patient-centered care.

Nouf Alsaheil¹, Nuha Alzaaqi¹2026-10-22

📄 medicine

Orbital Complications Following Acute Rhinosinusitis in Children: Clinical Outcomes Across Chandler Classification Stages

This retrospective study of 86 children with orbital complications from acute rhinosinusitis validates the Chandler classification's ability to differentiate disease severity and identifies time to CT imaging and admission duration as key predictors of severe outcomes.

Shruti Senthilkumar, Anurag Agarwal, Senthilkumar Rajamanickam, Rawa Al-Salihi2026-10-22

📄 medicine

A case of Erdheim-Chester disease involving the orofacial bones in a child

This paper reports a rare pediatric case of Erdheim-Chester disease characterized by extensive maxillofacial bone destruction and multisystem involvement, which was confirmed by histopathology and BRAF V600E mutation testing and successfully treated with targeted dabrafenib and trametinib therapy.

Moruo Deng, Hao Deng, Dan Li, Minhai Nie, Jian Wei, Yaoqiang Liu, Xuqian Liu2026-10-22

📄 medicine

“Biofilm Formation Among Clinical Urinary Isolates of Enterococcus Species: A Comparative Evaluation of Tissue Culture Plate, Congo Red Agar and Tube Methods in a Tertiary Care Hospital”.

This study aims to determine the prevalence of biofilm formation among clinical urinary Enterococcus isolates in a tertiary care hospital and to comparatively evaluate the performance of the Tissue Culture Plate, Congo Red Agar, and Tube methods for their detection.

Sowmya G Shivappa, Sindhu Sri Nagaraj, Morubagal Raghavendra Rao, Swetha M2026-10-22

📄 medicine

Dynamic prediction of severe complications after pancreatic resection: incremental value of the latest laboratory results and longitudinal history

This study demonstrates that while incorporating the latest laboratory values significantly improves the prediction of severe complications after pancreatic resection compared to static features, adding full longitudinal laboratory histories does not consistently provide further predictive gains.

Jingyun Ning, Ruiqi Li, Huihuang Yu, Jianfeng Huang, Haoming Lin, Rui Zhang2026-10-22

📄 medicine

Epidemic response performance in contested territory: a comparative analysis of Ituri and North Kivu during the 2026 Bundibugyo virus disease outbreak

This hypothesis-generating comparative analysis of the 2026 Bundibugyo virus outbreak in the DRC finds a statistically significant disparity in case fatality rates between government-administered Ituri and M23/AFC-contested North Kivu, suggesting that contested territorial control is associated with weaker response outcomes while acknowledging that epidemic phase and case-ascertainment differences remain plausible alternative explanations.

Marie Roseline Darnycka Belizaire, Steve Ahuca, Yap Boum II, Otim Patrick Cossy Ramadan, Ebenezer Obi Daniel, Dick Chaml (…)2026-10-22

📄 medicine

Mycophenolate mofetil as initial immunosuppressive therapy in Behçet’s uveitis: a retrospective cohort study

This retrospective cohort study of 15 Behçet's uveitis patients found that while mycophenolate mofetil (MMF) demonstrated some steroid-sparing potential as an initial immunosuppressive therapy, its high rates of relapse and discontinuation suggest it is better suited as a maintenance or adjunctive agent rather than a sole initial treatment for severe cases.

Hadeel Seraj, Hanan A. Alshalan, Roqayah AlMaradheef, Amani Mutlaq Alotaibi, Nora Alyousif, Shaikha Aldossari, Mohammed (…)2026-10-22

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