13808 papers
Topical application of the FAAH inhibitor URB597 exerts significant preventive anti-inflammatory and osteoprotective effects in a rat model of LPS-induced periodontitis by reducing alveolar bone loss, inflammatory mediators (TNFα and PGE2), and MMP activity.
This retrospective study of 44 pregnant patients suggests that lung scintigraphy for suspected pulmonary embolism delivers a low fetal radiation dose and is associated with generally reassuring pregnancy and childhood outcomes, though definitive conclusions about long-term safety are limited by the small sample size and lack of a control group.
This study demonstrates that in adult Fontan patients, resting oxygen consumption (rVO₂) varies significantly depending on the estimation method, with indirect calorimetry providing the most accurate values and predictive equations or CPET-derived estimates potentially leading to substantial errors in hemodynamic calculations like pulmonary vascular resistance.
This study utilizes latent class analysis on 2,055 female sex workers in post-invasion Ukraine to reveal that distinct migration and adversity profiles—specifically conflict-related versus personal adversity—differentially shape sexual health risks, highlighting the need for interventions tailored to individual displacement histories rather than relying solely on self-reported relocation status.
A national survey of Chilean children reveals that school-based physical activity promotion measures inadvertently widen the gap between children with and without disabilities, as these initiatives primarily benefit non-disabled peers while leaving children with disabilities more inactive and sedentary.
This CT-based study of 739 proximal humeri reveals that calcar bone density significantly declines with age and is lower in females, with elderly women showing the most severe bone loss that may compromise implant fixation in osteoporotic fractures.
This qualitative study, grounded in the Integrated Theory of Health Behavior Change, reveals that pregnant women's proactive engagement in pelvic floor health is shaped by dynamic interactions of fragmented knowledge, self-regulatory challenges, and unstable social support, suggesting a need for personalized, empowerment-oriented interventions that integrate credible digital tools and cultural sensitivity.
This ecological study of Ecuador (2006–2024) reveals that while maternal and neonatal mortality lack significant provincial-level spatial clustering due to a modifiable areal unit effect, a cantonal-level analysis uncovers critical geographic disparities where over 16% of cantons face simultaneous shortages of obstetric beds and workforce, highlighting specific infrastructure gaps distinct from workforce deployment as actionable targets for intervention.
This cross-sectional study of younger Indian adults with long-standing type 2 diabetes reveals that while cognitive screen-positive status correlates continuously with higher HbA1c levels and longer disease duration, the standard MoCA cutoff of <26 is ineffective for distinguishing diabetics from controls in lower-education populations, whereas a lower cutoff of <23 successfully identifies a significantly higher prevalence of screen-positive cases in the diabetic group.
This experimental study demonstrates that inhibiting beta-adrenergic receptors with propranolol upregulates Cx26 and Cx32 expression and reduces apoptosis in cumulus cells from women with PCOS and poor ovarian response, suggesting a novel therapeutic strategy to improve oocyte competence in assisted reproductive technologies.