📄 medicine

Ototoxicity Awareness and Knowledge Among Medical and Allied Health Students in Ghana: A Cross-Sectional Comparative Study

This cross-sectional study at the University of Health and Allied Sciences in Ghana reveals that medical students possess significantly higher awareness and knowledge of ototoxic medications compared to allied health students, highlighting a critical need for targeted educational interventions to address these disparities and improve future patient safety.

Bill Alfred Taylor, Christopher Anagi, Deborah Naa Ayekor Lamptey2026-07-13
📄 medicine

Association Between Toileting Behaviors and Overactive Bladder Symptoms among Female University Students in Lebanon and Armenia: A Comparative Study

This cross-sectional study of female university students in Lebanon and Armenia reveals that unhealthy toileting behaviors are significantly associated with overactive bladder symptoms in both populations, though specific behavioral patterns like delayed voiding in Lebanon and premature voiding in Armenia show distinct country-specific correlations.

Khalil Darwich, Rawad Affan, Georges Jarrouge, Daniel Panossian, Shafika Assaad2026-07-13
📄 medicine

Self-reported adverse drug reactions to Dolutegravir-Based First-Line Antiretroviral Therapy and associated factors in Ethiopian patients: A Cross-sectional study

This cross-sectional study conducted at Ayder Comprehensive Specialized Hospital in Ethiopia found that 38.9% of patients on Dolutegravir-based first-line antiretroviral therapy reported adverse drug reactions, with urban residence, earlier disease stage at initiation, treatment-naïve status, and concomitant medication use identified as significant associated factors.

Goitom Belay, Alemseged Beyene Berha, Haftom Niguse Abraha, Eyasu Makonnen2026-07-13
📄 medicine

ETS2/c-Jun Inflammatory Storm Interceptor: Smart Dual-Responsive Temporal Regenerative Engine Reprograms Degenerative Nucleus Pulposus Microenvironment

This study presents a smart, dual-responsive hydrogel microsphere that delivers a MEK inhibitor and citric acid in a temporally controlled sequence to suppress the ETS2/c-Jun inflammatory axis and reprogram the degenerative nucleus pulposus microenvironment, thereby achieving functional intervertebral disc regeneration.

Yusen Qiao, Jinhao Ni, Haifu Sun, Kang Wei, Xiaowei Zhang, Yuexing Wang, Yu Chen, Haowen Lu, Minbo Jian, Zijie Zhou, Lei (…)2026-07-13
📄 medicine

Intrinsic capacity and the physical frailty phenotype as complementary predictors of mortality in older Indian adults

This study of older Indian adults demonstrates that intrinsic capacity and the physical frailty phenotype are complementary rather than redundant predictors of mortality, with cognitive function specifically identifying high-risk individuals who appear physically robust but would otherwise be missed by frailty screening alone.

Bhrigu Jain, Aparajit Dey, Sharmistha Dey2026-07-13
📄 medicine

Understanding Contraceptive-Induced Menstrual Changes: Insights from contraceptive discontinuation due to side effects in 7 low- and middle-income countries

This multi-country analysis of seven low- and middle-income nations reveals that contraceptive-induced menstrual changes are a leading cause of method discontinuation, particularly among adolescents and injectable users, highlighting the urgent need to move beyond one-size-fits-all family planning approaches toward personalized contraceptive interventions.

Catherine Akoth, Caleb Nyakundi, Sharonmercy Okemwa, Dorcas Nzilani Kanini, Lilian Ngina, Nancy Muthoni Nyaga, Irene mul (…)2026-07-13
📄 medicine

Parthenolide enhances imatinib activity in gastrointestinal stromal tumor models through stress-associated apoptosis

This study demonstrates that parthenolide enhances the antitumor efficacy of imatinib in gastrointestinal stromal tumor models by inducing stress-associated apoptosis through mechanisms involving ROS elevation, mitochondrial dysfunction, and ER-stress pathway activation.

Longyi Piao, Zheng-Gen Piao, Chun-Hua Zheng, Dongyuan Xu, Xi-Hui Li, Pengcheng Wei, Cho Park, Chuang-Ming Zheng, Toufeng (…)2026-07-13
📄 medicine

A multimodal framework to assess differences in dynamic visual acuity between athletes with and without recent sport-related concussion

This study demonstrates that a multimodal dynamic visual acuity assessment performed during standing and walking can effectively differentiate athletes with a history of recent sport-related concussion from asymptomatic controls, revealing persistent visual-cognitive deficits despite clinical recovery.

Katelyn M. Mitchell, Kristine Dalton, Michael E. Cinelli2026-07-13
📄 medicine

Assessing Patient Safety Culture: A Pioneering Exploratory Study in a Mozambican Tertiary Hospital

This pioneering study in a Mozambican tertiary hospital reveals that while frontline teamwork is a strength, the patient safety culture is significantly compromised by systemic barriers including production pressure, a punitive environment, and inadequate feedback loops, necessitating targeted leadership and communication interventions.

Grácio Fenias Guambe, Elena Bohomol, Mohsin Sidat2026-07-13