medicine papers | Gist.Science

Immediate changes in cervical cancer early-detection knowledge and screening readiness after an experiential learning-based health promotion session in Indonesian Islamic study communities: a one-group pretest-posttest pilot study

This one-group pretest-posttest pilot study in Indonesian Islamic study communities demonstrates that an experiential learning-based health promotion session significantly improved adult women's immediate knowledge, attitudes, and readiness regarding cervical cancer early detection, though the findings remain preliminary pending further controlled longitudinal research to verify actual screening uptake.

Ayu Ulfah Nur Lubis, Asrial Asrial, Solha Efrida2026-07-13

📄 medicine

Proof of Concept of Surface Anticoagulation in Electrically Active Mechanical Mitral Valve Using Biomimetic Glycocalyx: In Vivo Swine Model Study

This study demonstrates that an electrically activated mechanical mitral valve, which mimics the negative charge of the endothelial glycocalyx, successfully prevented valve thrombosis and eliminated the need for long-term systemic anticoagulation in a swine model.

Lokeswara Rao Sajja, Thomas Mathew, Aditya Koppula2026-07-13

📄 medicine

SLC16A13 functions as a novel oncogenic driver in glioma by impairing monocarboxylate transport and mitochondrial redox homeostasis

This study identifies SLC16A13 as a novel oncogenic driver and independent prognostic biomarker in glioma that promotes malignant progression by impairing monocarboxylate transport and disrupting mitochondrial redox homeostasis, thereby highlighting its potential as a therapeutic target.

Shiqiang Yang, Yanwei Liu, Xuhui Hui, Anqiang Yang2026-07-13

📄 medicine

Isolated HBc IgM false reactivity in the absence of acute Hepatitis B: a case report

This case report describes a 28-year-old male with multiple sclerosis whose initial isolated HBc IgM positivity was determined to be a false-positive result caused by heterophile antibodies, as confirmed by undetectable viremia and negative results upon retesting with a heterophilic blocking tube.

Giuseppe Di Pietra, Michele Borghi, Maira Zoppelletto, Mariela Marinova2026-07-13

📄 medicine

Formal Correction of Pivotal Trial Publications Following FDA Safety Drug Withdrawals: A Systematic Case Series (1990 to 2024)

This systematic case series of 29 FDA-withdrawn drugs from 1990 to 2024 reveals that formal, machine-discoverable corrections to pivotal trial publications are exceptionally rare (occurring in only 1.6% of cases) because safety withdrawals typically stem from harms outside the scope of the original trials rather than from flaws in the published efficacy claims themselves.

Phani Kurada2026-07-13

📄 medicine

Polyexposure, Polysocial, and Polygenic Scores for Common, Complex Disease Classification and the Creation of a Clinical Exposure Assessment

This study demonstrates that integrating standardized polyexposure and polysocial scores with polygenic scores significantly improves the classification of common, complex diseases compared to genetic or demographic factors alone, while identifying largely distinct high-risk populations and providing a framework for a pragmatic clinical exposure assessment tool.

Alison Motsinger-Reif, Dillon Lloyd, Farida Akhtari, John House, Chirag Patel, Charles Schmitt, David Fargo, Lawrence Ki (…)2026-07-13

📄 medicine

Exploring Midwives’ Experiences with Intrapartum Care in Health Facilities in Ankole Sub-region, South Western, Uganda

This qualitative study of midwives in Uganda's Ankole Sub-region reveals that while they possess a strong professional drive, their intrapartum care delivery and career retention are significantly compromised by systemic limitations, resource shortages, and heavy workloads that lead to burnout and dissatisfaction.

Eve Katushabe, Mary Steen, Ayishetu Musa-Maliki2026-07-13

📄 medicine

Calibrated within-population patient individualisation of antimicrobial exposure: a pre-registered simulation and external-evaluation study

This pre-registered simulation and external-evaluation study demonstrates that a model-informed precision dosing engine, utilizing a compiled medical-knowledge substrate, successfully provides calibrated, unbiased, and more accurate within-population individualized dosing for narrow-therapeutic-index antimicrobials across diverse critical-care populations.

Youssef Ghaly2026-07-13✓ Author reviewed ⓘ

📄 medicine

Developing a School-based Mindfulness Intervention for Delivery in Rwanda and Ethiopia: Cultural Adaptation through Knotworking

This qualitative study details the co-creation of a culturally adapted, school-based mindfulness intervention for Rwanda and Ethiopia through a collaborative "knotworking" process that addressed local constraints like large class sizes and religious sensitivities to develop a feasible curriculum for low-resource settings.

Rachel Shanks, Stephanie Thomson, Charlaine Simpson, Pamela Abbott2026-07-13

📄 medicine

Nanoparticle-Mediated Modulation of the PINK1/Parkin Mitophagy Pathway in Parkinson’s Disease: A Scoping Review

This scoping review highlights the potential of nanoparticle-based delivery systems to overcome blood-brain barrier limitations and modulate the PINK1/Parkin pathway for Parkinson's disease treatment, while noting that current evidence is extremely limited to a single study and calls for more standardized research to validate clinical efficacy.

Clare Kingsley, Nicole Ahad, Kaleb Rodriguez, Alexa Q. Xiang2026-07-13

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