📄 medicine

Minimum intraoperative perfusion index is associated with end-of-surgery hyperlactatemia under general anesthesia

This single-center retrospective study of 186 patients undergoing general anesthesia found that a lower minimum intraoperative perfusion index (PI min) is significantly associated with end-of-surgery hyperlactatemia, suggesting PI min may serve as a simple marker for hypoperfusion-related metabolic stress despite its modest discriminative performance.

Ayaka Noda, Tomoo Yuba, Shunsuke Yamamoto, Akira Iura, Takeshi Yoshida2026-07-12
📄 medicine

Radiofrequency Ablation Turbinate Reduction for Rhinitis Medicamentosa: A Prospective Single-Arm Study of Nasal Obstruction, Quality of Life, and Decongestant Withdrawal in a Saudi Cohort

This prospective single-arm study of 12 Saudi patients demonstrates that radiofrequency ablation turbinate reduction is an effective treatment for rhinitis medicamentosa, successfully enabling complete decongestant withdrawal and significantly improving nasal obstruction and quality of life.

Fatimah Almarhoon, Hussain Albaharna2026-07-12
📄 medicine

Technical skepticism and institutional mistrust drive COVID-19 vaccine refusal: a global LLM- assisted survey

This global study utilizing large language models to analyze free-text survey responses from over 3,700 unvaccinated individuals reveals that COVID-19 vaccine refusal is primarily driven by specific technical concerns regarding mRNA safety and institutional mistrust rather than general anti-vaccination ideology, suggesting that transparent communication addressing these specific fears may be more effective than enforcement.

Aditi Bhargava, Sabra S. Inslicht2026-07-12
📄 medicine

Violet light induces apoptosis via the reactive oxygen species-mitochondrial signaling pathway in chordoma

This study demonstrates that violet light induces apoptosis in chordoma cells by increasing reactive oxygen species levels and triggering mitochondrial damage, suggesting a promising new therapeutic approach for this radiotherapy-resistant tumor.

Shunsuke Tamaki, Toshihiko Nishisho, Makoto Takeuchi, Shunichi Toki, Shinji Kawaguchi, Hiroaki Manabe, Keisuke Nishidono (…)2026-07-12
📄 medicine

Development and Usability of a Virtual Reality Human–Human Interface to Deliver Psychotherapy to People Experiencing Auditory Verbal Hallucinations, a feasibility study.

This feasibility study evaluated the usability and trust of a virtual reality AVATAR therapy interface across three groups, finding that while the system is generally user-friendly, individuals experiencing auditory verbal hallucinations perceive the avatar creation and interaction process as significantly more challenging than control and healthy participants.

Cian Lausch, Mona Redlich Bossy, Philipp Homan, Judith Rohde, Rainer Krähenmann, Stefan Vetter, Erich Seifritz, Stephan (…)2026-07-12
📄 medicine

Hybrid Educational Simulation Training for Parental Presence During Critical Situations in the Nicu: An Observational Study

This observational study demonstrates that a hybrid simulation training program, combining educational videos, role-playing with actors, and multidisciplinary debriefing, significantly reduced healthcare professionals' anxiety levels regarding parental presence during critical NICU events, though the findings are limited by the lack of a control group.

Cristina Felice Civitillo, Francisca Barcos Munoz, Tiphaine Corbisier, Francesca Cipolat, Angelo Polito, Alice Bordessou (…)2026-07-12
📄 medicine

Effect of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio on early neurological deterioration in patients with large artery atherosclerotic ischemic stroke

This retrospective study of 432 patients with large artery atherosclerotic ischemic stroke demonstrates that an elevated admission non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is an independent predictor of early neurological deterioration, suggesting its utility as a simple biomarker for early risk stratification.

Jinglong Sun, Yaqiang li2026-07-12
📄 medicine

Proportion and Associated Factors of Maternal Near Miss among Northwest Ethiopian women following Armed conflict: A Cross sectional study

This 2025 cross-sectional study at the University of Gondar Comprehensive Specialized Hospital in Northwest Ethiopia found that maternal near miss occurs in 14.3% of admitted women following armed conflict, with significant associations identified for primiparity, lack of antenatal care, and delays in seeking or receiving care.

Leul Endalamaw Demilew, Yemisrach Alemneh Ayanaw, Esmael Ali Mohammed, Bezawit Alemu Mengist, Misganaw Abere Worku, Asna (…)2026-07-12
📄 medicine

Bridging the Representation Gap in the Surgical Workforce: A Scoping Review of Programs and Interventions to Support Surgical Careers for Underrepresented Minority Learners

This scoping review maps diverse interventions supporting underrepresented minority learners in surgery, finding that while such programs are increasingly common and improve short-term metrics like interest and confidence, their impact is limited by inconsistent definitions and methodologies, highlighting the need for standardized, longitudinal, and institutionally embedded strategies to achieve durable representation gains.

Meerab Majeed, Aljeena Rahat Qureshi, Vidhi Bhatt, Ajibola Anifowose, Negeen Halabian, Armaghan Alam, David-Dan Nguyen (…)2026-07-12