13909 papers
This case report describes a rare instance of Langerhans cell histiocytosis in the thymus of a 37-year-old male, confirming the diagnosis through characteristic histopathology and immunohistochemical markers (CD1a+, S-100+, Langerin+) while reviewing relevant literature to discuss the disease's clinicopathological features and etiology.
This study in Zaria, Nigeria, reveals active Chikungunya virus transmission among patients with myo-arthritogenic illnesses, identifying a 13.6% RNA detection rate and significant risk factors such as proximity to bushes or dumpsites and poor preventive practices, thereby highlighting the urgent need for enhanced public awareness and integrated surveillance.
This study developed and temporally evaluated a multivariable prediction model using seven clinical features that successfully identified all adult patients with likely or unresolved cystic fibrosis for diagnostic testing while minimizing false positives among unlikely cases, though further prospective multicenter validation is required.
This retrospective observational study of 122 pediatric patients with IgA vasculitis nephritis and limited crescent formation found that while high-dose methylprednisolone pulse therapy achieved faster clinical remission and higher response rates at 1 and 3 months compared to low-dose therapy, both regimens demonstrated comparable long-term efficacy at 6 and 12 months, with the high-dose approach carrying a significantly higher risk of adverse reactions.
This qualitative study conducted in Iran reveals that women navigate the menopausal transition through a dynamic, individualized "Proactive Path to Relief" shaped by personal, social, and cultural factors, ultimately calling for patient-centered care and shared decision-making to support symptom management.
This multinational modified Delphi study engaged 40 healthcare professionals to reach consensus on key risk factors for drug-related problems in Emergency Departments, identifying high-risk prehospital drug administration, pharmacist intervention requests, and chronic drug use as the most relevant factors while highlighting the need for prospective validation of these findings.
This qualitative study reveals that Namibian diagnostic radiographers migrate abroad primarily due to domestic push factors such as limited career advancement, low pay, and poor working conditions, which are contrasted by pull factors from destination countries offering structured career progression, higher salaries, and well-equipped facilities.
This study demonstrates that inhibiting Chitinase-1 with kasugamycin reduces airway hyperresponsiveness and type 2 inflammation in multiple murine models of airway remodeling, identifying CHIT1 as a promising therapeutic target despite the need for further research to confirm its impact on structural fibrosis.
This cross-sectional study conducted in Western Ethiopia reveals a high prevalence (60.1%) of neonatal hypothermia among NICU admissions, identifying key associated factors such as lack of antenatal care, delayed breastfeeding initiation, obstetric complications, and specific neonatal characteristics like age under 24 hours, low birth weight, and underlying health problems.
This randomized controlled trial demonstrates that inhaling Cinnamomum camphora var. borneol essential oil (BEO) significantly reduces delayed vomiting severity and improves quality of life in cancer patients undergoing cisplatin-based chemotherapy, despite showing no significant effect on acute symptoms.