13909 papers
This retrospective cohort study of over 878,000 U.S. male veterans with erectile dysfunction found that the use of PDE5 inhibitors was significantly associated with a reduced incidence and delayed onset of Alzheimer's, frontotemporal, and vascular dementia, suggesting a potential protective role for these medications that warrants further prospective investigation.
This cross-sectional study of 190 puerperium women at Muko Health Centre IV in Uganda identifies that while most mothers attend antenatal care, the utilization of maternal health services is significantly influenced by distance, transport costs, maternal age, marital status, and partner support, highlighting the need to address these barriers to reduce maternal complications.
This case series from a tertiary care hospital in Pakistan describes five atypical extraintestinal Salmonella Typhi infections—including meningitis, thyroid abscess, spondylodiscitis, and hydatid cyst involvement—highlighting the importance of considering Salmonella in unusual focal infections within endemic settings and tailoring treatment based on culture and susceptibility testing.
This study of 300 cancer patients in Pakistan demonstrates a high prevalence of malnutrition (42.7%) that is significantly associated with advancing disease stage, reduced dietary intake, and functional decline, thereby validating the PG-SGA tool as an effective method for identifying at-risk patients who require early nutritional intervention.
This randomized controlled trial conducted in Lahore, Pakistan, demonstrates that adding oral zinc to standard therapy significantly improves asthma control and reduces emergency department visits in children aged 5–10 with moderate persistent asthma compared to standard therapy alone.
This study introduces a novel circulatory model utilizing the P life and R lac indices to predict mortality and guide individualized red blood cell transfusion decisions in critically ill patients, demonstrating strong predictive accuracy through internal and external validation.
This study demonstrates that *Bidens bipinnata* L. extract effectively alleviates hyperlipidemia in rats by modulating lipid profiles through a multicomponent, multitarget mechanism involving the regulation of key genes and pathways related to fatty acid oxidation, cholesterol metabolism, and apolipoprotein transport.
This randomized, double-blind, placebo-controlled, multi-center clinical trial demonstrates that the Shugan Jianpi Yangxin Prescription (SJYP) is an effective and safe treatment for insomnia disorder with liver depression and spleen deficiency, significantly improving sleep quality and comorbid symptoms while modulating specific serum metabolites and metabolic pathways such as the GABAergic synapse.
This counterfactual reanalysis of an IVF cohort estimates that approximately 22% of cleavage-stage transfers in low-zygote cycles were potentially futile because extended culture would have yielded no transferable blastocysts, suggesting that while day-3 transfers in these specific cases may be unnecessary, the findings should guide personalized counseling rather than dictate universal policy changes.
This scoping review reveals that Middle Eastern women diagnosed with coronary artery disease exhibit low levels of physical activity and poor participation in cardiac rehabilitation, highlighting a critical gap in research regarding the support and education needed to promote exercise in this population.