4098 papers
This retrospective study demonstrates that dual-energy CT-derived extracellular volume (ECV) fraction and its reduction following neoadjuvant chemotherapy are significantly associated with major histologic response in breast cancer patients, with lower post-treatment ECV values observed in those achieving a major response.
This secondary cross-sectional analysis of 15,000 adults reveals that while pre-sleep smartphone use and stress levels are independently associated with sleep quality and mental fatigue, the extremely strong correlation between stress and mental fatigue suggests significant construct overlap, and the study's cross-sectional design limits conclusions to associations rather than causation.
This qualitative evidence synthesis identifies that while caregivers in sub-Saharan Africa often begin malaria vaccination due to trust and visible health benefits, they frequently fail to complete the series due to premature satisfaction, logistical barriers, and household dynamics, necessitating a programmatic shift from securing initial acceptance to sustaining engagement through system alignment and supportive communication.
This qualitative study of 75 older adults across four Western countries reveals that while vaccine-positive individuals are open to combined RSV and hMPV vaccines, hesitant participants remain selective and concerned, highlighting a universal need for individualized information and GP recommendations to support future vaccination decisions.
The paper introduces UWFound, a domain-adapted foundation model that leverages self-supervised learning on ultra-widefield fundus images to achieve robust, hierarchical diagnosis and aetiological classification of posterior uveitis, significantly outperforming existing models in both internal and external validation scenarios.
This study demonstrates that an explainable machine learning model using early emergency department data achieves comparable or superior performance to established clinical risk scores in predicting 30-day mortality for upper gastrointestinal bleeding, offering a promising tool for improved risk stratification pending external validation.
This cross-sectional analysis of 250 dental implant videos on Chinese social media platforms reveals that while Bilibili offers the highest quality and most comprehensive educational content, overall information quality varies significantly across platforms, with clinically critical topics like treatment planning frequently overlooked and user engagement metrics proving unreliable as indicators of accuracy.
While a 32-week multicomponent exercise program did not significantly reduce arterial stiffness across all community-dwelling older adults, it produced clinically relevant vascular improvements in those with elevated baseline stiffness and lower physical activity, with increases in habitual moderate-to-vigorous physical activity emerging as the key independent predictor of reduced arterial stiffness.
This population-based analysis demonstrates that histological purity is an independent predictor of superior breast cancer-specific survival, confirming that the favorable prognosis associated with mucinous carcinoma applies specifically to pure mucinous carcinoma (PMC) rather than mixed mucinous carcinoma (MMC).
This mixed-methods feasibility study demonstrates that a tailored educational intervention is highly acceptable and practical for enhancing critical care nurses' mentoring competence in Norway, though future large-scale implementation requires improved recruitment strategies and organizational support.