medicine papers | Gist.Science

A Validated National Framework for Multi-Pathogen Wastewater-Based Epidemiological Surveillance in Kenya: From Pathogen Prioritisation to Real- Time Public Health Intelligence

This paper presents a validated, end-to-end national framework for multi-pathogen wastewater-based epidemiological surveillance in Kenya that integrates a structured pathogen prioritization matrix, a 57-site sampling network, standardized laboratory methods, and a real-time geospatial analytics platform to deliver actionable public health intelligence within seven days.

Leonard Kingwara, Rukia Madada, Harris Onywera, Samuel Oyola, Noah Hull, Isabella Ayagah, Victoria Kanana, Vera Onwonga (…)2026-10-13

📄 medicine

Neurodegenerative disorders: Stereotyped relationships between pathological metabolic topographies and the healthy default mode network

This study analyzes FDG PET scans from over 1,000 patients to categorize neurodegenerative disorders into three groups based on the degree of spatial overlap and correlation between disease-specific metabolic networks and the healthy default mode network, revealing that the extent of this overlap provides unique insights into whether the default mode network is primarily or secondarily involved in the disease process.

Matej Perovnik, David Eidelberg2026-10-13

📄 medicine

Functional–Structural Heterogeneity in AKI Recovery Across Renal Perfusion Phenotypes in Critical Illness

This study demonstrates that integrating renal perfusion phenotypes with functional and structural biomarkers, particularly cystatin C, reveals distinct heterogeneity in acute kidney injury recovery among critically ill patients, with combined perfusion–cystatin C states effectively predicting day-7 AKI outcomes.

Hongxiang Li, Yao Fu, Yuting Li, Youquan Wang, Dong Zhang2026-10-13

📄 medicine

Accuracy evaluation of an ultraviolet-C dosimeter based on CIELAB colour difference and its application in monitoring clinical surface disinfection

This study validates a CIELAB color-change-based UVC dosimeter as an accurate tool for detecting insufficient disinfection doses on clinical surfaces, revealing that simply extending exposure time fails to overcome dose inhomogeneity caused by environmental factors and necessitates optimized lamp placement strategies.

Youjian Zhang, Li Tan, Cong Shi2026-10-13

📄 medicine

Implementing routine glucocorticoid toxicity monitoring: a multilevel, theory informed qualitative study with three pillars of behaviour changes recommendations for clinical teams

This multilevel, theory-informed qualitative study identifies barriers and facilitators to routine glucocorticoid toxicity monitoring among clinicians and proposes three pillars of data-driven behavioral change recommendations to embed systematic assessment into clinical practice.

Vasilis S. Vasiliou, Callum Ewing, Joana Martins-Martinho, Ana Rita Lopes, Sarah Louise Mackie, Cristina Ponte, Raashid (…)2026-10-13

📄 medicine

Socioeconomic inequalities and determinants of institutional delivery among women in Ethiopia: a cross-sectional analysis of the 2024-2025 Ethiopia Demographic and Health Survey

Based on the 2024–2025 Ethiopia Demographic and Health Survey, this study reveals that while 61.3% of women delivered in health facilities, institutional delivery remains significantly concentrated among socioeconomically advantaged women, with wealth, education, and urban residence being key determinants that necessitate targeted equity-focused policies.

Fazle Rabby, Md. Ripul Kabir2026-10-13✓ Author reviewed ⓘ

📄 medicine

Intranasal Human Olfactory Mucosa-Derived Neural Stem Cells Restore Neuroplasticity and Suppress Neuroinflammation in a Rat Model of Chronic Stress-Induced Depression

This study demonstrates that intranasal administration of human olfactory mucosa-derived neural stem cells effectively alleviates chronic stress-induced depression-like behaviors and neuroinflammation in rats by restoring neurogenesis and neuroplasticity, with repeated dosing yielding superior therapeutic outcomes.

Fatemeh Naghizadeh, Somayeh Niknazar, Ali Dadseresht, Elham Seidkhani, Rafieh Alizadeh, Arezo Nahavandi2026-10-13

📄 medicine

Serum Calcium-Phosphate Product and the Risk of Kidney Replacement Therapy or In-Hospital Death in Critically Ill Patients with Rhabdomyolysis: a Multicohort Database Study

This multicohort study demonstrates that higher early serum calcium-phosphate product levels are consistently and significantly associated with an increased risk of requiring kidney replacement therapy or in-hospital death in critically ill adults with rhabdomyolysis.

Zheng Yao, Zhaotao Fang, Shijia Zhu2026-10-13

📄 medicine

Successful Trastuzumab Deruxtecan Treatment After AdjuvantTrastuzumab-Induced Heart Failure: A Case Report

This case report demonstrates that trastuzumab deruxtecan (T-DXd) can be a safe and effective treatment option for recurrent HER2-positive breast cancer in a patient who previously experienced trastuzumab-induced heart failure, provided that cardiac function has sufficiently recovered and is closely monitored.

Hiromi Fuchikami2026-10-13

📄 medicine

Proximate low birth weight in three regions of Ethiopia with high stunting prevalence: Evidence from the 2016 Ethiopian demographic and health survey

Using 2016 Ethiopian Demographic and Health Survey data, this study reveals a high prevalence of proximate low birth weight (35.9%) in Ethiopia's three most stunted regions, identifying rural residence, specific regional locations, female infant sex, multiple births, and young maternal age as significant risk factors that underscore the need for targeted interventions to address both low birth weight and childhood stunting.

Mesfin Wudu Kassaw, Ayele Mamo Abebe, Kirubel Dagnaw Tegegne, Tewodros Mulugeta Nigussie, Selam Tadele Markos2026-10-13

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