medicine papers | Gist.Science

The Real-World Experience of Niemann-Pick Disease Type C: Patient and Caregiver Perspectives to Inform Future Therapeutic and Policy Directions

This international cross-sectional survey of patients and caregivers reveals that Niemann-Pick disease Type C imposes a profound multidimensional burden characterized by universal neurological involvement and significant psychosocial strain, while highlighting critical global inequities in diagnosis, fragmented care pathways, and unequal access to therapies that necessitate improved diagnostic awareness and standardized patient-centered outcomes.

Krista Casazza, Sandra Cowie, Toni Mathieson, Justin Hopkin, Shaun Bolton2026-10-13

📄 medicine

Early post-discharge outcomes of children under five years admitted with Diarrhoea in three Regional Referral Hospitals (Amana, Temeke, and Mwananyamala) in Dar es Salaam

This prospective cohort study of 180 children under five in Dar es Salaam found that while high caregiver adherence to treatment and favorable WASH conditions led to significant nutritional recovery and low mortality post-discharge, a notable proportion of children still experienced recurrent diarrhoea and readmissions, highlighting the need for strengthened discharge education and structured follow-up.

Ramadhani Issa Mshuti, Karim Manji2026-10-13

📄 medicine

Structured Modality Dropout for Robust MRI-Based IDH Mutation Classification in Glioma

This study proposes a structured modality dropout training strategy for a 3D ResNet18 model that significantly enhances the robustness and calibration of non-invasive IDH mutation classification in glioma across realistic MRI scenarios where one or more imaging modalities are missing.

Mohisha Mongia, Piyush Gupta, Satya P Singh2026-10-13

📄 medicine

Oral Health Status in Children with Autism Spectrum Disorder: A Comparative Cross-Sectional Study from Venezuela

This comparative cross-sectional study from Venezuela found that children with autism spectrum disorder exhibited lower dental caries experience and better oral hygiene than neurotypical controls, although these differences were partially influenced by age disparities between the groups.

Mariana Morales, Mery Baute2026-10-13

📄 medicine

The effect of the clinical oriented reasoning examination on anxiety and perceived stress levels in nursing students: A quasi-experimental study

This quasi-experimental study found that while nursing students' state anxiety significantly decreased after taking a clinical oriented reasoning examination, their trait anxiety and perceived stress remained unchanged, suggesting the assessment does not disadvantage students with higher baseline anxiety but highlighting the need for controlled designs to isolate the effects of the exam format.

Banu Terzi, Fatma Dursun Ergezen, Emine Kol2026-10-12

📄 medicine

Directed Education Committee (DEC) as process for Individualized Education Plans (IEP) for Residents with Struggles: Analysis with RE-AIM Framework

This retrospective mixed-methods study demonstrates that the Directed Education Committee (DEC), a delegated subcommittee that structurally separates evaluation, advocacy, and content-expert roles, effectively supports struggling residents through individualized education plans while reducing role conflict and achieving high competency outcomes without significant demographic disparities.

Erum Azhar, Hadia Khan, Hamna Salimi, Mahanoor Raza, Kaylette Jenkins, Benjamin Ihms, Laila Younes, Abdul Waheed2026-10-12

📄 medicine

Is Obtaining Specific Consent for Educational Skill Training on Patients Necessary? An Analysis of Arguments For and Against Among Chinese Medical Students

This study of 559 Chinese medical trainees reveals significant differences in consent preferences across specialties, with surgical residents and students favoring explicit separate consent while anesthesiology residents prefer a risk-stratified approach, highlighting the urgent need for tiered consent policies to balance patient autonomy, trust, and educational necessity amidst prevalent patient distrust.

Min Xu, Lizhen Wang, Jiaqi Chen, Yan Meng, Yali Xie, Ke Chen, Kun Ye2026-10-12

📄 medicine

Couples’ attitudes toward domestic violence and reproductive health care use in sub-saharan africa

This study of 21 Sub-Saharan African countries finds that couples who jointly reject domestic violence are more likely to utilize prenatal care and deliver in health facilities, while husbands' rejection of violence specifically predicts higher contraceptive use, suggesting that policies should target male partners through stricter laws and awareness campaigns to improve reproductive health outcomes.

Emeline Jacqueline TOSSOU, Dimitri TCHAKOUNTE2026-10-12

📄 medicine

Effects of Small-Sided Basketball Games and High-Intensity Interval Training on Body Composition, Cardiovascular Health, and Physical Performance in Sedentary Young Adults: A Randomized Controlled Trial

This randomized controlled trial demonstrates that an 8-week heart-rate-matched small-sided basketball game intervention yields physical and cardiovascular adaptations equivalent to high-intensity interval training in sedentary young adults, while offering lower perceived exertion and potentially better long-term adherence due to its recreational nature.

Musen Wei, Baodong Yang, Jiawei Chen, Zhanfei Zheng, Xinjie Han2026-10-12

📄 medicine

Clonal evolution and molecular profiling of recurrent maxillary ameloblastoma with lung metastasis harboring SMO and PIK3CA mutations

This study characterizes a case of recurrent maxillary ameloblastoma with lung metastasis harboring identical SMO and PIK3CA mutations, highlighting the potential of Hedgehog and PI3K signaling pathways as therapeutic targets in aggressive odontogenic tumors.

Yuji Yagamuchi, Kumiko Oka, Yuka Tamura, Ryozo Miyagi, Yasuhisa Ohde, Takashi Mukaigawa, Kenichi Urakami, Fuyuki Sato2026-10-12

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