4098 papers
This prospective cohort study demonstrates that pre-operative microbiome signatures, specifically the concurrent colonization of *Enterococcus faecalis* and *Klebsiella pneumoniae*, serve as independent predictors of aggressive prostate cancer phenotypes and significantly improve risk stratification beyond conventional clinical markers like PSA.
This study of 386 outpatients with Major Depressive Disorder reveals that while specific ICD-11 personality traits directly influence suicidal ideation, the quality of object relations and defense mechanisms serve as significant mediating factors, highlighting the importance of targeting these psychodynamic structures in therapeutic interventions.
In patients with moderate-to-severe ARDS, continuous anterior chest compression improves right ventricular function and reduces afterload in those who exhibit a paradoxical decrease in plateau pressure due to overdistension, whereas it worsens ventilation/perfusion matching by increasing shunt in non-responders.
This systematic review and meta-analysis of 1,091 high-risk elderly patients with prior ischemic stroke despite oral anticoagulation found that left atrial appendage closure is associated with a residual annual ischemic stroke recurrence rate of 3.1%, highlighting the need for prospective trials to optimize post-procedural antithrombotic strategies.
This study demonstrates that circulating soluble P2X7 receptor (sP2X7R) levels progressively increase throughout normal pregnancy, reflecting physiological inflammatory adaptations and serving as a potential biomarker for maternal-fetal immune interactions and specific pregnancy-related conditions.
This review examines the emerging role of antibody-drug conjugates (ADCs) as a therapeutic option for advanced or recurrent high-grade endometrial cancer by summarizing their current clinical applications, preclinical evidence, and early-phase trial results, while also addressing the mechanisms of resistance and future challenges in overcoming them.
This study demonstrates that China's Healthy City pilot policy significantly improved cognitive health and reduced cognitive health inequality among older adults by enhancing living environments, health behaviors, social participation, and digital inclusion, with effects varying across demographic and regional groups.
This six-month prospective pilot study comparing selective and complete caries removal in deep posterior lesions found that selective removal showed a clinically relevant, numerically higher success rate and pulp sensibility than complete removal, although the difference did not reach statistical significance in a two-sided analysis, highlighting the need for larger, longer-term trials.
This study protocol outlines a three-arm randomized controlled trial comparing the efficacy of neuromuscular electrical stimulation, supervised combined aerobic and resistance exercise, and health literacy education on glycemic control and secondary outcomes in institutionalized older adults with type 2 diabetes over a 12-week period.
This study demonstrates that tirzepatide ameliorates diabetes-induced testicular inflammation, oxidative stress, and sperm DNA fragmentation in obese diabetic mice through a GIPR-mediated mechanism in testicular macrophages, offering protective effects beyond its glycemic control capabilities.