13909 papers
This study presents an explainable machine-learning framework utilizing plantar-force gait biomarkers and ordinal modeling to achieve high-accuracy, objective staging of Parkinson's disease severity across Hoehn–Yahr stages 2.0 to 3.0 while identifying key interpretable gait features such as double-support phase and bilateral asymmetry.
This national cross-sectional survey characterizes the emerging French Paramedical Research Coordinator (PRC) workforce, revealing that while the role has been successfully institutionalized with high academic qualifications and a strategic focus, its implementation remains unevenly distributed and under-resourced outside university hospitals.
Through a constructivist grounded theory analysis of interviews with Black women survivors of intimate partner violence and a collaborative workgroup, this study identifies depression as a critical psychosocial need and initiates the co-tailoring of a culturally specific intervention that integrates interpersonal counseling with faith and spirituality.
This comparative cross-sectional study in Nigeria reveals that juvenile systemic lupus erythematosus is the most common paediatric rheumatic disease and that health-related quality of life in affected children is significantly lower than in healthy peers, primarily driven by functional disability and pain levels.
This study evaluates the early impact of the 2023 U.S. Supreme Court ruling banning race-conscious admissions, finding that it has already led to declines in matriculation rates for Black, Hispanic/Latino, and Pacific Islander applicants to U.S. medical schools, raising concerns about future diversity in the physician workforce.
This case report highlights the importance of considering methemoglobinemia in children with persistent low pulse oximetry readings despite normal clinical status and cardiopulmonary workups, emphasizing that the discrepancy between low saturation and preserved arterial oxygen tension serves as a critical diagnostic clue to avoid unnecessary investigations.
This prospective cohort study of 381 women found that cesarean scar niches are highly prevalent (63.8%) and are independently predicted by higher BMI, emergent delivery, and hormonal contraceptive use, with larger defects associated with diabetes and lower fetal head station, yet neither the presence nor severity of the niche correlated with increased short-term postpartum symptoms.
This study of 897 people who use opioids in Baltimore reveals that methadone and buprenorphine treatments are associated with distinct sociodemographic profiles and risk patterns, with methadone users showing higher injection frequency but lower recent overdose rates, while buprenorphine users exhibit lower co-use but higher lifetime overdose histories, suggesting a need for tailored harm reduction strategies for each treatment modality.
This study of a Swedish pediatric cohort demonstrates that whole-genome sequencing identifies pathogenic genetic variants in 16% of patients with coarctation of the aorta, supporting the routine use of genetic testing to uncover underlying disorders even in the absence of overt clinical signs.
This post hoc analysis of the Phase III RENOTORCH trial reveals that lipid-lowering therapy use is significantly associated with improved overall survival specifically in patients with advanced renal cell carcinoma treated with toripalimab plus axitinib, but not in those treated with sunitinib.