4098 papers
This paper reports the first documented case in the Mediterranean region of visceral leishmaniasis complicated by hemophagocytic lymphohistiocytosis in a patient treated with the IL-17 inhibitor ixekizumab, which was successfully managed with liposomal amphotericin B before the patient was switched to guselkumab.
This large-scale retrospective study of over 23,000 patient-years demonstrates that sublingual immunotherapy (SLIT) administered via a telemedicine model is safe, characterized by predominantly mild adverse events and exceptionally low rates of severe reactions, anaphylaxis, and eosinophilic esophagitis.
Using a system dynamics model based on New South Wales data, this study projects that despite potential policy improvements, significant gender disparities in leisure-time physical activity will likely persist among middle-aged and older adults by 2035, necessitating urgent and targeted systemic interventions to achieve equity.
This study reports the development of a novel, cost-effective fusion protein (NGF2) that combines a stabilized FGF2 variant with an albumin-binding domain to simultaneously overcome the inherent instability and short circulation half-life of native FGF2, thereby enabling its practical application in next-generation cell regeneration therapies.
This cross-sectional study at a Nigerian teaching hospital reveals that 76.6% of adolescents attending a family medicine clinic face psychosocial risks—primarily substance use and sexual health issues—which are significantly associated with socio-demographic factors, thereby underscoring the feasibility and necessity of integrating the culturally adapted HEADSSSS framework into routine primary care screenings.
This study demonstrates that an explainable machine learning ensemble model, utilizing uroflowmetry data and SHAP analysis, can accurately and consistently classify pediatric lower urinary tract dysfunction subtypes while identifying key clinical predictors, though further external validation is needed before clinical implementation.
This qualitative study utilizing focus groups and thematic analysis reveals that while cataract surgery significantly enhances older adults' visuomotor abilities, driving confidence, and social participation, it also highlights the critical need for consistent healthcare information to support patient independence and manage expectations regarding recovery.
This retrospective-prospective cohort study demonstrates that individualized software-assisted trocar planning, combined with intraoperative geometric verification and argon plasma coagulation, significantly reduces conversion rates, postoperative complications, and hospital stays compared to conventional methods in laparoscopic appendectomy for acute appendicitis.
This study utilizes an integrated in silico approach to identify specific phytochemicals from *Desmodium gangeticum* as promising dual modulators of MAO-B and 5-HT2A receptors, offering a potential multi-target therapeutic strategy to simultaneously address both motor and neuropsychiatric symptoms in Parkinson's disease.
This bibliometric analysis of 3,265 publications from 2006 to 2026 reveals that global KRAS-targeted cancer research has rapidly evolved from indirect pathway inhibition to a precision oncology frontier focused on direct mutant inhibition, resistance mechanisms, and allele-specific targeting beyond G12C, with the USA and China leading in output and impact.