📄 medicine

Pathological lesions of the oral mucosa in children and adolescents based on microscopic examination: a comparative analysis of systemically healthy patients and patients with systemic diseases

This study demonstrates that oral mucosal lesions in systemically ill children and adolescents differ significantly from those in healthy peers by presenting with a distinct histopathological profile characterized by a higher prevalence of inflammatory granulation tissue and ulceration, necessitating careful clinicopathological correlation for medically compromised patients.

Ewa Krasuska-Sławińska2026-07-21
📄 medicine

Fluctuating hypokalemia with late-onset hypomagnesemia and evolving acid–base disturbance: a case report

This case report describes a 20-year-old female with hypovolemic shock and profound hypokalemia whose condition, initially mimicking distal renal tubular acidosis but ultimately attributed to gastrointestinal losses, only stabilized after correcting refractory hypomagnesemia, underscoring the critical need for serial monitoring in complex electrolyte disturbances.

Khandaker Abdul Sadib2026-07-21
📄 medicine

Computational In Silico Screening of Himalayan Phytochemicals Against the Oncogenic Chaperone Protein (AGR2): Exploring Nepal's Biodiversity for Accessible Cancer Therapeutics

This study utilizes in silico virtual screening to identify 11-O-Galloyl bergenin and related Himalayan phytochemicals as novel, high-affinity inhibitors of the oncogenic chaperone AGR2, establishing a preliminary structure-activity relationship for future experimental validation.

Sambriddha Karki2026-07-21✓ Author reviewed
📄 medicine

Cumulative Victimization Types, Trauma-Related Symptoms, Psychological Distress, and Resilience Among Adults in Residential Treatment for Substance Use Disorders

This cross-sectional study of 107 adults in Portuguese residential substance use treatment reveals that cumulative lifetime victimization is significantly associated with increased trauma symptoms and psychological distress while being negatively linked to resilience, with notable gender differences in victimization exposure and mental health outcomes.

Luís Costa2026-07-21
📄 medicine

Short-term antiproteinuric effects of disease-modifying therapies for IgA nephropathy: a systematic review and Bayesian mechanism-class indirect comparison

This systematic review and Bayesian indirect comparison of randomized trials up to June 2026 found that APRIL/BAFF-axis therapies demonstrated the largest short-term antiproteinuric effect among disease-modifying treatments for IgA nephropathy, though these class-level estimates remain indirect and do not establish head-to-head superiority.

Nawaf AM Alharbi, Ahmed AlOmar, Osama AL-Tuwayjiri, Ahmad Abdullah M. Abaalkhail, Fajer Abdullah Abaalkhail, Adi Abaalkh (…)2026-07-21
📄 medicine

Translation and Psychometric Validation of the Mental Health Literacy Scale in Hindi (MHLS-HI): A Cross-Sectional Study of a Four-Factor Structure Among Hindi-Speaking Indian Adults

This study presents the translation and psychometric validation of the Mental Health Literacy Scale into Hindi (MHLS-HI), demonstrating its reliability and a robust four-factor structure among Hindi-speaking Indian adults, thereby providing a culturally grounded tool for research and targeted interventions.

Himanshu Thakur, Geetesh Kumar Singh2026-07-21
📄 medicine

Patient journeys in paediatric rheumatology in a low-resource setting: diagnostic delays, treatment barriers, and outcomes at a zonal referral hospital in Northern Tanzania

This case series of three children at a Tanzanian referral hospital highlights how prolonged diagnostic delays, limited access to affordable testing and monitoring, and financial barriers in low-resource settings lead to severe morbidity and mortality in paediatric rheumatic diseases, underscoring the urgent need for strengthened frontline recognition, referral pathways, and diagnostic infrastructure.

Une Robinson, Elton Roman2026-07-21
📄 medicine

Severity levels of DSM-5 somatic symptom disorder in medical inpatients: assessing clinical relevance in a cross-sectional sample

This cross-sectional study of nearly 3,000 medical inpatients in Switzerland demonstrates that DSM-5-defined somatic symptom disorder severity levels, particularly the distinction between mild and severe cases, are clinically relevant as they correlate significantly with varying degrees of mental health impairment, though physical health status remained similar across severity groups.

Sebastian Dietsche, Franziska Weeren, Gunther Meinlschmidt, Anne Toussaint, Nikolia Cicic, Iris Baenteli, Alexander Fric (…)2026-07-21