13396 papers
This study reveals that autonomic cholinergic signaling drives acute myeloid leukemia progression and chemoresistance through a dual mechanism involving direct activation of leukemic cells via nicotinic receptors and indirect induction of stem cell quiescence in the bone marrow niche, suggesting that targeting this pathway could improve AML treatment outcomes.
This single-center cross-sectional study of adults newly diagnosed with type 2 diabetes during the COVID-19 pandemic in Türkiye found that treatment success was primarily driven by pharmacological adherence and baseline glycemic status, with a cautionary note on an unexpected association between prior COVID-19 infection and improved outcomes.
This multicenter cross-sectional study developed and internally validated a parsimonious logistic regression model identifying night-shift burden, work stress, and career adaptability as key predictors for moderate-to-severe insomnia among Chinese nurses, achieving modest discrimination (AUC ~0.71) where machine learning offered no significant advantage over traditional methods, thus highlighting the need for external validation before clinical application.
This study demonstrates that ROR1 is frequently overexpressed in metastatic triple-negative breast cancer, where its presence correlates with poor prognosis and increased T-cell infiltration, supporting the rationale for targeted ROR1 therapies in clinical trials.
This large-scale time-stratified case-crossover study of over 3.7 million deaths in Brazil reveals that dementia and drowning exhibit the strongest heat-related mortality risks, while challenging the prevailing assumption that common cardiometabolic conditions like obesity and diabetes significantly increase heat susceptibility.
In a phase IIb/III trial involving 238 immunocompromised adults, the PHH-1V protein-based booster vaccine demonstrated enhanced immunogenicity against Omicron variants and was well-tolerated, eliciting durable antibody and T-cell responses particularly in people living with HIV and those on hemodialysis, though responses were limited in anti-CD20-treated autoimmune disease patients.
This study of elite male adolescent athletes reveals that while dynamic balance, spinal mobility, and hamstring flexibility vary across sports, individual body fat percentage and hamstring flexibility are the primary independent predictors of balance performance, suggesting that monitoring these modifiable factors is more critical for identifying balance deficits than focusing on sport discipline alone.
This study characterizes a Swedish tertiary-care sample of young children with avoidant/restrictive food intake disorder (ARFID) as presenting with sensory-based avoidance and low interest in eating, frequently accompanied by significant medical comorbidities and neurodevelopmental difficulties that underscore the need for early screening and multidisciplinary intervention.
A 19-year survey of 3,585 Parkinson's disease patients in Israel reveals a progressively declining survival rate compared to the general population, with males and those aged 60–69 experiencing the shortest median survival times, highlighting the limitations of current symptomatic therapies.
This case report describes the incidental diagnosis of moderate congenital factor XI deficiency in a 3-year-old Moroccan boy during preoperative screening for circumcision, highlighting the importance of investigating isolated prolonged aPTT even in the absence of a significant bleeding history to ensure appropriate management before invasive procedures.