📄 medicine

Cancer Immunotherapy Implementation in Crisis-Affected MENA Settings (Lebanon, Sudan, and Iraq): A Pilot Descriptive-Analytical Cross-Sectional Study of Barriers, Clinical Readiness, and Policy Priorities

This pilot descriptive-analytical study of 23 oncology professionals in Lebanon, Sudan, and Iraq reveals that cancer immunotherapy access is severely limited by high costs, political instability, and supply chain disruptions, while confirming the feasibility of the research instrument for a future, larger-scale investigation to guide urgent policy and multilateral interventions.

Gazy EBRAHIM2026-07-21✓ Author reviewed
📄 medicine

Fast Food, Digital Food Delivery Systems, and Gut Microbiota Disruption Among University Students: Mechanisms, Health Implications, and Future Directions

This review elucidates how the convergence of habitual fast-food consumption and the algorithmic promotion of nutritionally poor options via digital delivery platforms disrupts gut microbiota diversity and function among university students, thereby increasing their risk for chronic inflammation and metabolic disorders while calling for targeted interventions to address both dietary and digital environmental factors.

Muhammad Moiz Amir2026-07-21
📄 medicine

Non-genetic factors play more important role in lansoprazole metabolism than CYP2C19 pharmacogenetic profiles in European patients with burns

In European burn patients, non-genetic factors such as age, sex, BMI, smoking, and substance abuse exert a greater influence on lansoprazole metabolism than CYP2C19 pharmacogenetic profiles, suggesting that genetic testing is unnecessary for personalized dosing in this population.

Natálie Mlčůchová, Jan Böhm, Jaroslav Janošek, Ondřej Zendulka, Jana Gregorová, Ondřej Peš, Michaela Fiamoli, Břetislav (…)2026-07-21
📄 medicine

Patient incivility and Nurses' Behaviours to Maintain Patient Dignity: The moderating role of Future time orientation

This study demonstrates that while patient incivility negatively impacts nurses' behaviors to maintain patient dignity, this adverse effect is significantly buffered by nurses' future time orientation, suggesting that cognitive training and institutional protections can enhance humanistic care.

Cong Guo, Mengqi Zhu, Juju Huang, Yucai Ding, Lingling Chen, Yuling Xu, Cheng Wang, Rui Huo, Caiyan Ding, Tong Zhou, Yon (…)2026-07-21
📄 medicine

Clinical Application of Modified Karydakis Flap Procedure for Pilonidal Cyst: A 2-Year Single-Center Retrospective Cohort Study

This 2-year retrospective cohort study demonstrates that a modified Karydakis flap procedure incorporating an additional scalp needle drainage tube at the natal cleft significantly reduces postoperative seroma and wound complications, accelerates recovery, and lowers recurrence rates compared to the standard technique without increasing surgical trauma.

Jianheng Wang, Qianqian Wang, Min Liu, Zhigang Zhang, Chunxiang Liu, Penglin Liu2026-07-21
📄 medicine

Supra-inguinal versus infra-inguinal fascia iliaca compartment block for postoperative analgesia in elderly patients undergoing proximal femoral fracture surgery: a prospective randomized double-blind trial

This prospective randomized double-blind trial demonstrates that in elderly patients undergoing proximal femoral fracture surgery, an ultrasound-guided supra-inguinal fascia iliaca compartment block provides superior postoperative analgesia and reduces opioid consumption compared to the infra-inguinal approach.

Sabrine Ben Brahem, Ichraf Ardhaoui, Hela Ben Said, Firas Kalai, Hichem Belhadj Kacem, Mohamed Amine Selmene, Lotfi Reba (…)2026-07-21
📄 medicine

Prognostic Utility of the Endothelial Activation and Stress Index in Critically Ill Patients with Heart Failure and Acute Kidney Injury: A Dual-Cohort and Machine Learning Validation Study

This dual-cohort study with machine learning validation demonstrates that the admission Endothelial Activation and Stress Index (EASIX), a simple score derived from three routine biomarkers, is a robust, independent, and dose-dependent predictor of short- and long-term mortality in critically ill patients with concomitant heart failure and acute kidney injury, offering predictive accuracy comparable to complex clinical scoring systems.

Fengli Li, Meiling Zhao, kangxing Wang, Meng Yuan2026-07-21
📄 medicine

The Double Burden of Adolescents in Bandung, West Java, Indonesia: Undernutrition and Emerging Metabolic Risks

A cross-sectional study of 203 adolescents in Bandung, Indonesia, reveals a double burden of malnutrition where undernutrition, normal weight, and overnutrition coexist with high rates of metabolic and lipid abnormalities, particularly dyslipidemia, indicating that metabolic risk assessment must extend beyond BMI alone.

Lilik Sukesi, Noormarina Indraswari, Novina Novina, Ahmedz Widiasta, Ria Bandiara, Yunia Sribudiani, Wiem Bony, Nanny Na (…)2026-07-21
📄 medicine

Community-Based Social and Behavior Change Communication for Health Promotion in Fragile Settings: Evidence from Somalia

This mixed-methods study on health promotion in Somalia demonstrates that Social and Behavior Change Communication (SBCC) is most effective in fragile settings when it leverages trusted community structures, particularly religious leaders and radio, to overcome barriers like low literacy and cultural misconceptions while integrating with routine health systems.

Mohamed Mohamoud Hassan2026-07-21