13396 papers
This study of mastectomy patients who did not receive radiation found that positive surgical margins significantly increase the risk of local-regional recurrence, suggesting margin status should be considered when deciding on adjuvant radiation therapy.
This cross-sectional secondary analysis of 6,322 Chengdu adults reveals that 38.4% experienced poor sleep, which was significantly associated with lower mental health literacy, chronic conditions, poor self-rated health, and depressive and anxiety symptoms.
This study successfully developed and optimized amino-functionalized mesoporous silica nanoparticles encapsulated in hard gelatin capsules to significantly enhance the oral bioavailability, dissolution, and cytotoxic efficacy of pazopanib for the treatment of renal cell carcinoma.
This systematic review and meta-analysis of 11 studies involving over 20,000 adults in Cameroon reveals a pooled Type 2 diabetes prevalence of 3.5% that has significantly increased over time, particularly among older populations, underscoring the urgent need for enhanced surveillance and targeted prevention strategies.
This study elucidates the anti-inflammatory and protective mechanisms of Viticis Fructus and its stir-fried processed form against acute lung injury by integrating network pharmacology, metabolomics, and experimental validation to identify key compounds, targets, and the PI3K-AKT signaling pathway.
In a Brazilian real-world cohort of rheumatoid arthritis patients treated within the public health system, disease activity and functional capacity failed to show sustained improvement over 12 months of biologic DMARD therapy, highlighting that effectiveness observed in high-income countries may not translate to this setting and underscoring the need for closer monitoring and timely therapeutic adjustments.
An expert-based assessment comparing ChatGPT and Gemini for postoperative tonsillectomy education in Turkish found no statistically significant difference in overall quality or safety between the two models, underscoring the necessity for clinician review before using AI-generated patient information.
This conceptual review synthesizes evidence to propose that sport functions as "social medicine" by reducing loneliness and promoting social health through interconnected biological, psychological, and social pathways, as illustrated by the newly introduced Biopsychosocial Loop Model.
This scoping review of 61 studies across 25 low- and middle-income countries reveals that while the integration of indigenous health knowledge into formal systems is hindered by structural isolation and a lack of rigorous outcome data, the proposed Integrated Community Health Systems (ICHS) framework offers a six-pillar policy architecture to bridge this gap and improve health outcomes.
This study provides the first molecular and serological evidence of silent *Rickettsia* spp. circulation in the non-endemic Alagoas State of Brazil, revealing high exposure rates in dogs and horses and identifying them as key sentinel species for spotted fever surveillance.