medicine papers | Gist.Science

District-Level Supervision and Stakeholder Recommendations for Strengthening Routine Health Information System Data Quality in Osun State, Nigeria: A Qualitative Study

This qualitative study in Osun State, Nigeria, reveals that while district-level supervision functions as a coherent cycle for improving Routine Health Information System data quality, its reliability is hindered by shared logistical constraints, and stakeholders' prioritization of training over incentive structures suggests a critical gap between perceived needs and the systemic changes required for sustainable improvement.

Sunday Akingbola Omokanye, Olayinka Isiaka Baruwa, Olutunde Samuel Michael2026-10-10

📄 medicine

Beyond Single-Axis Inequality: An Intersectional MAIHDA Analysis of Major Cardiovascular Disease in Europe

This study utilizes an intersectional MAIHDA approach on data from 30 European countries to demonstrate that while major cardiovascular disease is socially patterned, these inequalities primarily stem from the accumulation of measured disadvantages like low income and male gender rather than unique effects specific to particular social intersections.

Ana Margarida Pereira Silva, Juan A López-Rodríguez, Luis Andrés Gimeno-Feliu2026-10-10

📄 medicine

Short-term cardiac autonomic responses to primary immunization in hospitalized term and preterm infants: the prospective PVAD study

This prospective study found that primary immunization in hospitalized term and preterm infants did not result in a statistically significant, sustained short-term alteration in cardiac autonomic regulation, as measured by heart rate variability indices over 48 hours.

Fiona Semporé¹, Vincent Pichot², Hugues Patural¹˒²2026-10-10

📄 medicine

A decade of developments in dermatological care within Dutch nursing homes: a repeated cross-sectional study

This repeated cross-sectional study comparing Dutch nursing home physicians from 2013–2014 and 2024 reveals that while the use of teleconsultation and availability of diagnostic tools have significantly increased over the past decade, the rising burden of cutaneous (pre)malignancies highlights an urgent need for targeted education and skills training to bridge the gap between available resources and physician competence.

M. (Marleen) van Oosterhout, J. (Jos) M.G.A. Schols, R. (Raymond) T.C.M. Koopmans, E. (Elke) M.G.J. de Jong, S.(Satish) (…)2026-10-10

📄 medicine

The Relationship Between Spiritual Health and the Provision of Spiritual Care to Patients Among Iranian Nurses

This 2024 cross-sectional study of 151 Iranian nurses reveals a significant positive correlation between their personal spiritual health and their competence in providing spiritual care to patients, suggesting that enhancing nurses' spiritual well-being can improve their ability to address patients' spiritual needs.

Razieh Montazeralfaraj, Mohammad Ali Zareian Baghdadabadi, Elahe Rahmani2026-10-10

📄 medicine

BSC9 a betulin–acetazolamide conjugate enhances radiosensitivity in 2D and 3D HNSCC models

The study demonstrates that BSC9, a bifunctional conjugate of acetazolamide and 3-O-acetylbetulin, enhances radiosensitivity in head and neck squamous cell carcinoma by inducing ROS accumulation, DNA damage, and mitochondrial dysfunction, particularly under hypoxic conditions, thereby validating its potential to overcome hypoxia-associated radioresistance.

Danny Knobloch-Sperlich, Matthias Kappler, Markus Glaß, Antje Güttler, Marina Petrenko, Jonas Pyko, Tony Gutschner, Fran (…)2026-10-10

📄 medicine

Platelet Activation in Bronchial Asthma according to asthma endotype and clinical severity Short Title: Platelet Activation in Bronchial Asthma

This study demonstrates that severe bronchial asthma, particularly the type-2-allergic endotype, is characterized by heightened platelet activation and reduced levels of D-series resolvins, suggesting that an imbalance between pro-inflammatory platelet activity and impaired inflammation resolution contributes to poor disease control.

Rossella Liani, Isotta Altomare, Paola Giustina Simeone, Margherita Alfonsetti, Matteo Mucci, Stefano Lattanzio, Alessia (…)2026-10-09

📄 medicine

Valproate-Induced Hyperammonemic Encephalopathy in a Child with Down Syndrome Despite Therapeutic Serum Valproate Levels: A Case Report

This case report describes an 8-year-old boy with Down syndrome who developed severe, rapid-onset hyperammonemic encephalopathy with normal liver function and therapeutic valproate levels, suggesting that underlying mitochondrial dysfunction in Down syndrome may increase susceptibility to this adverse drug reaction.

Riyam Alanazi2026-10-09

📄 medicine

Health-related quality of life of palliative patients with cancer in South Africa and the Democratic Republic of Congo: a cross-sectional multi-centre study with matched European controls

This cross-sectional multi-centre study reveals that palliative cancer patients in South Africa and the Democratic Republic of the Congo experience significantly higher levels of unmanaged symptoms and poorer health-related quality of life compared to matched European controls, highlighting an urgent need to improve and expand accessible palliative care services in these regions.

Micha J. Pilz, Albert M. Tambwe, Johannes M. Giesinger, Lara Hallsson, Juan I. Arraras, Ronita Mahilall2026-10-09

📄 medicine

Spermine inhibits ferroptosis in vascular dementia rats by intervening Nrf2/SLC7A11/GPX4 expression in chondriosome

This study demonstrates that spermine ameliorates cognitive deficits and neuronal injury in vascular dementia rats by inhibiting TRPM2-mediated oxidative stress and activating the Nrf2/SLC7A11/GPX4 pathway to suppress ferroptosis.

Hui-dan Wang, Yun-ting Wang, Yu-hang Xie, Pei-yao Liu, Meng-yao Zhao, Rui Hao, Hong-dou Zhang, Peng Li2026-10-09

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