📄 medicine

Sex-Specific Associations Between Pubertal Stage and Objectively Measured Physical Activity in Early Adolescence: Evidence from the ABCD Study

Using data from 4,794 adolescents in the ABCD Study, this research reveals that while physical activity generally declines and sedentary time increases with advancing puberty, these changes occur earlier in males than in females, highlighting mid-to-late puberty as a critical window for sex-specific interventions to preserve daily movement.

Mengyao Li, Hui Xie, Qiuyuan Qin, Michael Siniatchkin, Binx Yezhe Lin, Jiaojiao Hou2026-10-09
📄 medicine

Sex and Gender Bias in Clinical Practice: Evidence from a Simulation-Based Quasi-Experimental Study in Spain

A quasi-experimental study across four Spanish medical faculties reveals that implicit sex and gender bias significantly lowers the quality of care provided to female patients during the early, interpretative stages of clinical decision-making, such as symptom assessment and diagnosis, while later protocolized stages remain unaffected.

Cristina Pujol, Lluís Medir, Judit Vall Castelló2026-10-09
📄 medicine

The non-HDL cholesterol to HDL cholesterol ratio exhibits a ‘U’-shaped relationship with suicidal ideation in adolescents with depressive disorders: a cross-sectional study

This cross-sectional study of 291 adolescents with depressive disorders reveals a significant 'U'-shaped nonlinear relationship between the non-HDL to HDL cholesterol ratio and suicidal ideation, identifying a critical threshold of 2.63 where the risk is highest, thereby suggesting that both abnormally low and high lipid metabolism levels are associated with increased suicide risk in this population.

Ting Wang, Ya-Qin Zhao, Ping Zhao, Jiao-Jiao Sun, Wen-Huan Xiao, Nan Liu, Jia Li2026-10-09
📄 medicine

Intrapulmonary Migration of Implanon Requiring Thoracotomy and Pneumonotomy

This paper reports a rare case of a 27-year-old woman who underwent a successful thoracotomy and pneumonotomy to remove an Implanon contraceptive implant that had migrated from her arm into her left lower lung lobe, underscoring the critical need for early imaging and surgical intervention when such devices become non-palpable.

Samuel Tesfaye, Yohannis Chalchisa, Olana Reta, Getahun Geremew2026-10-09✓ Author reviewed ⓘ
📄 medicine

An independent third-party autoverification platform iXLAB Verify and its application in a core clinical biochemistry laboratory

The study demonstrates that iXLAB Verify, an independent third-party autoverification platform compliant with CLSI and WS/T guidelines, achieved high validation accuracy and significantly reduced turnaround times across outpatient, inpatient, and health check settings in a core clinical biochemistry laboratory.

Baohu Zhang, Li Chen, Chao Chen, Qingshan Lin, Gengzhen Zheng, Rongying Fan, Lin Cen, Wenjing Feng, Yu Chen, Shan Zhang (…)2026-10-09
📄 medicine

Molecular–Histologic Concordance in Kidney Allograft Biopsies: Clinical Utility of Molecular Microscope® Diagnostic System in Real-World Practice

This retrospective study of 219 kidney allograft biopsies demonstrates that integrating the Molecular Microscope® Diagnostic System (MMDx) with standard histology significantly improves diagnostic confidence and refines rejection phenotyping, particularly in challenging borderline, C4d-negative, and DSA-negative cases, without altering short-term graft outcomes.

Neva Bezeljak, Nika Kojc, Miha Arnol, Željka Večerić-Haler2026-10-09
📄 medicine

Testing the feasibility of neurofeedback interventions in mental, behavioural and neurodevelopmental disorders

This paper demonstrates that neurofeedback interventions are feasible to deliver across seven clinical studies targeting various mental, behavioural, and neurodevelopmental disorders, as all studies met pre-defined success criteria for recruitment, retention, and intervention uptake despite variability in study designs and populations.

Rachel McNamara, Elizabeth Randell, Rebecca Playle, Kerenza Hood, Susana Mouga, Miguel Castelo-Branco, Manfred Hallschmi (…)2026-10-09
📄 medicine

Night-shift frequency and loneliness among NHS employees: a multi-site cross-sectional analysis of the INTERACT study

This multi-site cross-sectional analysis of the INTERACT study found that among NHS employees, increasing monthly night-shift frequency is significantly associated with higher levels of loneliness, with exploratory findings suggesting that work-life balance and social fulfilment may mediate this relationship.

Austen El-Osta, Li Haoran, Sami Altalib, Waseem Jerjes, Shriti Pattani, Azeem Majeed, Bob Klaber2026-10-09
📄 medicine

Between procedural safeguards and the patient’s best interests: physicians’ experiences with judicial substitute consent in Poland—a cross-sectional survey

A cross-sectional survey of 159 Polish physicians reveals that while judicial substitute consent serves as a vital safeguard for incapacitated patients, its procedural delays often create ethical and legal tensions by hindering timely, life-saving treatment and increasing providers' fear of liability.

Michał Sekuła, Maciej Dubaj, Marcin Czop, Agnieszka Kowalska-Olczyk, Rafał Patryn2026-10-09