13910 papers
This study demonstrates that while perceptually designed novel hemodynamic alarms can be identified, their response times and accuracy are significantly compromised by the presence of concurrent proprietary alarms, highlighting the critical need for careful temporal and spectral design to maintain perceptual clarity in complex clinical acoustic environments.
This paper describes the methodology and outcomes of a 24-hour in situ translational simulation in a human biocontainment center that integrated a real patient and video-reflexive ethnography to generate system-level insights and demonstrate how patient participation can enhance healthcare evaluation and improvement.
This cross-sectional study at Ayder Comprehensive Specialized Hospital in Ethiopia reveals that while postpartum women who underwent cesarean delivery generally possess good knowledge and favorable attitudes toward postpartum care, their actual practices—particularly regarding neonatal physical examinations—are inconsistent and significantly influenced by maternal and partner education levels as well as antenatal care attendance.
This study identifies a stability-selected four-gene signature (BMP1, KIF15, TRAF3, PDGFA) as an independent prognostic factor for lower-grade glioma that was externally validated in a separate cohort, though the authors caution that the score reflects a proliferation-high, matrix-remodeling state rather than true mitoxyperilysis and lacks transportable absolute-risk utility.
This umbrella review of 38 systematic reviews reveals that adverse drug withdrawal reactions occur with highly variable incidence and symptom profiles across different medications—particularly CNS drugs—highlighting the urgent need for standardized detection and reporting criteria to better distinguish physiological withdrawal from disease relapse.
The study identifies compound 12e, a novel HDAC6/HIF-1α dual inhibitor, as a promising therapeutic candidate for triple-negative breast cancer that effectively halts malignant progression and reprograms the immune microenvironment through synergistic multi-pathway inhibition.
This study demonstrates that IgM antibodies from chronic complex regional pain syndrome patients induce pronociceptive effects specifically in the spinal cord, but not the skin, of fracture mice by targeting glial fibrillary acidic protein (GFAP) and activating complement and cytokine pathways, suggesting a temporal shift in autoantibody targets from both skin and spinal neoantigens to primarily spinal neoantigens as the disease progresses.
This paper analyzes cross-country variations in e-cigarette risk perceptions among smokers and demonstrates through randomized experiments that public health messaging significantly influences these perceptions, with the U.K.'s risk-reduction message correcting misconceptions while the U.S. message exacerbated them.
In a prospective cohort study of term pregnancies, ultrasound-based fetal weight estimation demonstrated greater accuracy and correlation with actual birth weight than clinical estimation using Johnson's formula, although the latter remains a practical alternative in resource-limited settings, particularly noting that clinical accuracy decreases as maternal BMI increases.
This study establishes age- and sex-specific reference intervals for laboratory parameters in healthy Beijing adults by analyzing longitudinal data from 2010 to 2026, identifying key aging inflection points to demonstrate that uniform reference intervals systematically misclassify physiological aging—particularly in peri- and post-menopausal women—as pathology.