13925 papers
This study presents the largest population-scale pharmacogenomic analysis to date in Jordan, revealing significant regional genetic variations in drug-metabolizing enzymes and establishing that nearly all participants carry at least one clinically actionable genetic variant, thereby providing a critical foundation for implementing precision medicine in the Levant.
This study developed and validated a robust physiologically based pharmacokinetic (PBPK) model for riociguat and its active metabolite M1 that accurately predicts complex pharmacokinetic behaviors, including enterohepatic circulation, food effects, hepatic impairment, and drug-drug interactions, thereby supporting clinical dose optimization and risk assessment.
This narrative review analyzes Ghana's unique model of embedding Public Health Units within hospital governance structures as a replicable solution to the clinical-public health divide in low- and middle-income countries, identifying 40 implemented facilities while highlighting critical needs for dedicated financing, workforce development, and clarified accountability to ensure sustainable integration.
This policy analysis argues that Somalia must transition from fragile aid dependence to a sequenced, multi-channel domestic resource mobilization strategy—prioritizing immediate efficiency gains, followed by health and broad-based taxes, and long-term insurance and Islamic finance—to achieve universal health coverage amidst external funding cuts.
This study demonstrates that a sustained-release Ag₂O/UiO-66@Heracleum persicum nanocomposite effectively combats vancomycin-resistant Staphylococcus aureus urinary tract infections by exhibiting potent antibacterial and antibiofilm activities, downregulating resistance and biofilm-associated genes, and maintaining high cytocompatibility.
This single-center retrospective cohort study of 375 acute ischemic stroke patients treated with intravenous thrombolysis found that higher admission blood urea nitrogen levels are independently associated with poor functional outcomes at both 90 days and 1 year, although the predictive accuracy of models incorporating this biomarker requires external validation before clinical application.
This case report describes a 43-year-old male with HIV/HCV-related cirrhosis and severe thrombocytopenia who achieved complete resolution and 12-month recurrence-free survival of recurrent chronic subdural hematoma following a novel multimodal "repair window" regimen combining rhTPO, atorvastatin, and hyperbaric oxygen therapy, though the authors note that causality remains unproven due to confounding factors.
A study of 120 water samples from food establishments in Aba, Nigeria, revealed that while overall microbial contamination was low and not significantly linked to water source or facility type, parasitic contamination was prevalent (10%) and significantly associated with itinerant water supplies, highlighting a critical need for improved water treatment and surveillance to prevent foodborne illnesses.
This cross-sectional study of 67 children and adolescents with cancer in Saudi Arabia reveals a substantial burden of anxiety and depression, particularly among females, older adolescents, and those receiving combined treatments, while also highlighting a unique, elevated preoccupation with death that underscores the urgent need for integrated psycho-oncology services and locally derived normative data.
A cross-sectional survey of 73 healthcare professionals in a French hospital revealed substantial and heterogeneous knowledge gaps in pediatric pain management, particularly regarding morphine, highlighting the need for targeted, role-specific education and standardized clinical protocols.