📄 medicine

Healthcare resource utilization, direct medical costs, and the temporal trends for patients with major depressive disorder in China: a 6-year retrospective analysis

This 6-year retrospective analysis of over 32,000 patients in Shenzhen, China, reveals that while major depressive disorder imposes significant economic burdens primarily through tertiary hospital inpatient care, the system is characterized by undertreatment in outpatient services and declining costs, highlighting an urgent need to strengthen primary care, optimize referral systems, and implement early intervention strategies.

Jiejing Hao, Wenjing Zhou, Lan Guo, Wanxin Wang, Huimin Zhang, Yuhua Liao, Yifeng Liu, Subinuer Yiming, Ruiying Chen, Ch (…)2026-07-09
📄 medicine

Measuring Leprosy Case Detection Delay and Associated Factors in Southeast Nigeria: A Community-Based Study

This community-based mixed-methods study in Southeast Nigeria reveals that leprosy case detection delays are substantially prolonged, averaging 74 months and driven primarily by patient-related factors such as low awareness, stigma, and reliance on informal care, rather than health system delays.

Chinwe Eze, Ngozi Murphy-Okpala, Charles Nwafor, Joseph Chukwu, Daniel Egbule, Martin Njoku, Okechukwu Ezeakile, Anthony (…)2026-07-09
📄 medicine

Adverse childhood experiences and adult stress eating: A secondary analysis of the Southern Community Cohort Study

This secondary analysis of the Southern Community Cohort Study reveals that adverse childhood experiences are significantly and dose-dependently associated with frequent adult stress eating, a relationship that persists even after adjusting for mental and emotional well-being.

Sydney R. Aquilina, Martha J. Shrubsole, Julia Butt, Maureen Sanderson, David G. Schlundt, Mekeila C. Cook, Meira Epplei (…)2026-07-09
📄 medicine

Lay concepts and perceptions of malaria among the Acholi in post-conflict Gulu District, Northern Uganda: A Qualitative Study

This qualitative study reveals that among the Acholi in post-conflict Gulu District, Uganda, malaria health-seeking behaviors are shaped by a complex interplay of local symptom-based understandings, diverse causal beliefs ranging from environmental to spiritual factors, and experiences with the health system, necessitating that control interventions engage with these community knowledge systems to improve effectiveness.

Wilfred Opobo, Madinah Nabukeera, James Mugisha2026-07-09
📄 medicine

Clinical Significance of Bacillus Species other than Bacillus anthracis: A Case Series With Review of Literature

This case series from India demonstrates that non-anthracis Bacillus species are clinically significant opportunistic pathogens capable of causing bacteremia and sepsis, particularly in neonates and immunocompromised patients, and should not be dismissed as contaminants to ensure timely targeted treatment and favorable outcomes.

Shreya Veggalam, Maheshwar Reddy Kandi, Venkataramana Kandi2026-07-09
📄 medicine

The Relationship Between Moral Distress, Psychological Capital, and Compassion Fatigue in Pediatric Nurses: A Network Analysis

This multicenter cross-sectional study utilized network analysis to identify specific moral distress items and key bridging symptoms (hope and secondary trauma) that link moral distress, psychological capital, and compassion fatigue among pediatric nurses, providing a targeted foundation for future interventions.

Liusai Wei, Ming Wei, Dongying Chen, Chunhong Wei, Hui Jiang, Wen Gao2026-07-09
📄 medicine

Evaluation of anti-arthritic activity of aripiprazole through multi models: new potential of an old drug

This study demonstrates that the antipsychotic drug aripiprazole exhibits significant anti-arthritic potential across in silico, in vitro, and in vivo models by suppressing inflammation, stabilizing cell membranes, and modulating pro- and anti-inflammatory cytokines, suggesting its viability for drug repurposing as a treatment for arthritis.

Aroosa Akber ., Alamgeer ., Hafiz Muhammad Irfan ., Shoaib Nawaz .2026-07-09
📄 medicine

Pathological patterns of stillbirth placentas and related variables for both fresh and macerated stillbirth at Bugando Medical Center in Mwanza, Tanzania

This study at Bugando Medical Center in Tanzania found that maternal vascular malperfusion is the most common placental pathology in stillbirths, with acute chorioamnionitis significantly associated with fresh stillbirths, underscoring the critical need for routine placental histopathology to guide future pregnancy management.

Yahaya Magaso, Edrick Elias, Mary Ndibalema, Benson Kidenya, Dismass Matovelo2026-07-09