📄 Category

medicine

14263 papers

📄 medicine

Collapsing Focal Segmental Glomerulosclerosis Progression to ESRD Following Combination Therapy with Pembrolizumab and Enfortumab Vedotin: A Case Report

This case report describes a 76-year-old male with pre-existing chronic kidney disease who experienced rapid, irreversible progression to end-stage renal disease due to collapsing focal segmental glomerulosclerosis following combination therapy with pembrolizumab and enfortumab vedotin, suggesting a novel synergistic mechanism of podocyte injury that warrants careful nephrology evaluation before treatment.

George Hitti, Caroline Gee, Johnathan Zuckerman, Ramy Hanna2026-10-11
📄 medicine

Genome-based benchmarking of 177 different breast cancer polygenic risk scores

This study benchmarks 177 breast cancer polygenic risk scores in a hereditary breast and ovarian cancer cohort, demonstrating that top-performing scores converge on similar accuracy and variant composition, thereby offering a cost-effective tool to stratify risk for patients lacking monogenic findings and close a critical diagnostic gap.

Ertugrul Eyol, Ulrike Faust, Marc Sturm, Antje Stäbler, Silja Gauß, Kristin Bosse, Ines Gruber, Andreas Hartkopf, German (…)2026-10-11
📄 medicine

Manual Sleep Stage and Arousal Scoring Agreement between a Reduced Montage and Conventional Polysomnography in Adults with Obstructive Sleep Apnea

This retrospective study demonstrates that a self-applied reduced frontal EEG montage achieves substantial agreement with conventional polysomnography for manual sleep stage and arousal scoring in adults with obstructive sleep apnea, offering a viable alternative for reliable sleep assessment when full PSG is impractical.

Megan McPhee, Kristófer Montazeri, Þóra Björg Sigmarsdóttir, Sigurður Ægir Jónsson, Eydís Arnardóttir, Eysteinn Finnsson (…)2026-10-11
📄 medicine

Incidence, outcomes, and mortality of fungal infections in pediatric patients undergoing anticancer therapy or transplantation: a nationwide cohort study

This nationwide cohort study of Polish pediatric patients reveals that while the incidence of invasive fungal disease is comparable between those undergoing anticancer therapy and hematopoietic cell transplantation, the latter group faces a nearly fourfold higher infection-related mortality rate, underscoring the urgent need for improved supportive care and prophylaxis.

Monika Richert-Przygonska, Anna Fraczkiewicz-Jablonska, Krzysztof Czyzewski, Patrycja Zalas-Wiecek, Olga Gryniewicz-Kwia (…)2026-10-11
📄 medicine

Facilitative Effects of Add-on Therapy with Tadalafil in Stone Passage After Shockwave Lithotripsy; A Randomized Clinical Trial

This randomized clinical trial found that while adding tadalafil to tamsulosin did not significantly improve stone passage rates or time after shockwave lithotripsy, it did significantly reduce pain scores and the duration of hematuria with negligible additional side effects.

Ali Kamalati, Mohammadamin Hesamarefi, Amir Hossein Hassani, Mohammadhadi Hesam-Arefi, Hamid Pakmanesh2026-10-11
📄 medicine

Immunosenescence shapes the inflammatory response to viral infection in vaccinated and unvaccinated patients

This study demonstrates that immunosenescence significantly shapes the inflammatory response to viral infection by altering neutrophil dynamics and cytokine levels in both vaccinated and unvaccinated patients, with the combination of the pan-immune-inflammation value (PIV) and specific cytokines serving as highly accurate predictors of infection status, particularly in individuals aged 65 and older.

Bartosz Kudlinski, Jagoda Kania, Magdalena Murkos, Jacek Zawadzki, Edyta Wawrzyniak-Gramacka, Barbara Morawin, Magdalena (…)2026-10-11
📄 medicine

Case Report: A novel de novo pathogenic variant in COL1A1 causing osteogenesis imperfecta (OI) in a Chinese girl

This case report describes the first identification of a novel de novo pathogenic variant (c.406G > T, p.Gly136Ter) in the COL1A1 gene causing osteogenesis imperfecta in a Chinese girl, highlighting the importance of genetic testing for diagnosing the condition in children with recurrent fractures even when typical extra-skeletal features are absent.

Xinfeng Wang, Wei Wang, Liangfu Xie, Bing E, Yuhuan Liu, Guibing Fu, Jiansheng Wang2026-10-11
📄 medicine

Effects of Eye–Hand Coordination Training in Immersive Virtual Reality Environments on Reaction Time and Tactical Effectiveness in Male Youth Handball Players: A Randomized Controlled Trial

This randomized controlled trial demonstrates that an 8-week immersive virtual reality hand–eye coordination training program significantly improves auditory and visual reaction times in male youth handball players, while also showing non-significant positive trends in tactical effectiveness and cognitive processing speed.

Xurxo Rivas, Paula Lorenzo Estévez, Adriana López Rodríguez, José María Cancela Carral2026-10-11
📄 medicine

Physical Activity, Muscle Phenotypes, and Functional Health Outcomes Among Middle-Aged and Older Chinese Adults: A Multi- wave Cohort Study Using CHARLS

This multi-wave cohort study of Chinese adults aged 50 and older reveals that while physical activity is more strongly linked to concurrent muscle strength than to future muscle abnormalities, low grip strength is a clearer predictor of subsequent functional decline and deteriorating self-rated health than low muscle mass.

Shiyuan Shao, Hongjuan Li2026-10-11
📄 medicine

Network Analysis of Return-to-Work Readiness and Self-Efficacy Among Breast Cancer Patients by Return-to-Work Status: A Cross-Sectional Study

This cross-sectional network analysis of 501 breast cancer patients in China reveals that while the overall structure of return-to-work self-efficacy networks does not significantly differ between those who have and have not returned to work, the specific central and bridge nodes vary by status, suggesting that vocational rehabilitation assessments should be tailored to emphasize readiness and stress coping before returning to work, and motivation and energy support after resuming employment.

Qiu Huo, Yunxia Pu, huizhuo Deng, Xianqiong Feng2026-10-11