📄 medicine

Temporal Trends in Match Success and Its Determinants Among International Medical Graduates: A National Resident Matching Program Analysis, 2016-2024

This national analysis of 2016–2024 NRMP data reveals that while USMLE Step 2 scores have become less predictive of residency match success for both US and non-US International Medical Graduates, research publication output has emerged as an increasingly critical determinant, particularly for non-US IMGs navigating visa-related challenges.

Yifei Wang, Leona Odabachian, John Geisler, Kelly Manahan2026-07-20
📄 medicine

Pulmonary Angiomatoid Fibrous Histiocytoma Invading the Pulmonary Vein with Intracranial Metastasis: A Case Report

This case report documents the first known instance of a 77-year-old male developing intracranial metastasis from a rare pulmonary angiomatoid fibrous histiocytoma, highlighting the tumor's aggressive potential, diagnostic challenges due to its resemblance to lung cancer, and the critical need for multidisciplinary management and molecular confirmation in older patients.

Yifei Tu, Yurun Xia, Zhen Wang2026-07-20
📄 medicine

Managing Atypical Chondrosarcomas: An Analysis of Prognostic Factors and Surgical Outcomes

This retrospective study of 20 patients with rare atypical localization chondrosarcomas identifies histological grade as the strongest predictor of survival and soft tissue involvement as a critical factor for local control, while demonstrating that surgical resection can achieve high long-term survival and satisfactory functional outcomes.

Tekin Can GÖKŞEN, Aras PERVANE, Meltem GÖKŞEN, Hayati TÜRKOĞLU, Mesut MISIRLIOĞLU, Coşkun ULUCAKÖY2026-07-20
📄 medicine

Predicting poor physical fitness among university students using five-year repeated campus surveillance data: development and temporal validation of a risk model

Using five years of linked campus surveillance data from a Chinese university, this study developed and temporally validated a risk model that identifies underweight and obesity as nonlinear, dual risk factors for poor physical fitness among students, achieving moderate predictive performance for pre-test screening while highlighting the need for local recalibration before clinical deployment.

Junhui Zhu, Mingling Zhao, Yan Bu2026-07-20
📄 medicine

Intensive robotic gait rehabilitation for persistent post-traumatic foot drop after tibial fracture and postoperative compartment syndrome case report

This case report demonstrates that intensive robotic gait rehabilitation can achieve meaningful late functional recovery of ankle dorsiflexion and near-normal walking in a patient with persistent post-traumatic foot drop following tibial fracture and compartment syndrome, after conventional physiotherapy had failed to produce further improvement.

Mohd Faizal Jalil2026-07-20
📄 medicine

Regional Disparities and Determinants of Health Human Resource Allocation in China’ s Primary Healthcare institutions

This study analyzes the significant growth yet persistent regional disparities in China's primary healthcare human resources over the past decade, identifying inter-regional differences and key socioeconomic factors as primary drivers of uneven distribution to inform future policy for the "Healthy China 2030" initiative.

Ruxin Kou, Yixia Wang, Yan Wang, Sixian Du, Qianqian Xu, Haixia Wang, Xinping Zhang, Ying Xiong2026-07-20
📄 medicine

Targeting uPAR with engineered extracellular vesicles from HEK 293T cells suppresses tumor growth in uPAR positive glioma models

This study demonstrates that engineered extracellular vesicles derived from HEK293T cells, which co-express a uPAR-targeting domain, TRAIL, and a suicide gene, effectively suppress uPAR-positive glioblastoma growth through targeted accumulation and synergistic apoptosis induction in murine models.

qi liu, yichao dong, xiaona yan, honglei chen, peng li, zian cheng, chang zhao, changlong guo, xu ma2026-07-20
📄 medicine

The Naples Prognostic Score Predicts Long-Term Outcomes in Critically Ill Patients with First Acute Myocardial Infarction: A Retrospective Cohort Study from the MIMIC-IV 3.2 Database

This retrospective cohort study of 2,003 critically ill patients with first-time acute myocardial infarction demonstrates that the Naples Prognostic Score, calculated from early ICU admission data, is a simple and independent predictor of increased long-term all-cause mortality and adverse cardiovascular events.

Weixu Yu, Qingyuan Cai, Mengyuan Pang, Lili Zhong, Meijuan Li, Bingbo Hou2026-07-20
📄 medicine

Longitudinal estimated glucose disposal rate trajectories and cumulative exposure predict cardiovascular disease in population with Cardiovascular- Kidney-Metabolic syndrome stages 0-3: A nationwide prospective cohort study

This nationwide prospective cohort study demonstrates that worsening longitudinal trajectories and lower cumulative exposure of estimated glucose disposal rate (eGDR) are significant predictors of cardiovascular disease incidence in individuals with Cardiovascular-Kidney-Metabolic syndrome stages 0–3, with these associations being particularly pronounced in non-diabetic populations and partially mediated by lipid factors.

Yifei Xiang, Hongpeng Chen, Haitao Cao, Anan Huang, Jie Wang, Bingchen Liu2026-07-20
📄 medicine

A Rare Case of Giant Ectopic Pheochromocytoma with Severe Tumor Adhesion in a Patient with Diabetes Mellitus: A Case Report

This case report describes a rare instance of a giant ectopic pheochromocytoma in a 78-year-old diabetic woman that presented with severe adhesions to adjacent organs, likely exacerbated by chronic inflammation, and was successfully managed through multidisciplinary surgical intervention.

Weihu Cen, Zhaozhong Luo, Hailei Liu, Minjie Zhang, Fa Tang, Qichun Li, Jun Shen2026-07-20