7910 papers
This case report highlights a diagnostic challenge where a rare FIGO stage IA dedifferentiated endometrial carcinoma in a 33-year-old woman was initially misdiagnosed as cervical high-grade neuroendocrine carcinoma, underscoring the critical need for comprehensive tissue sampling and judicious immunohistochemistry to ensure accurate staging and appropriate management.
This realist, mixed-methods study evaluates the implementation of the "Best For You" integrated care model in Northwest London, revealing that despite significant contextual barriers like the pandemic and infrastructure limitations, persistent stakeholder motivation and adaptive planning enabled the successful redesign of paediatric emergency mental health services.
This qualitative study in Uganda reveals that while family caregivers for ADRD patients face significant multidimensional challenges driven by cultural expectations and limited resources, their selection is rooted in relational bonds and their experiences are simultaneously enriched by personal growth, empathy, and a sense of fulfillment, highlighting the urgent need for culturally tailored support interventions.
This retrospective study of very-low-birth-weight infants reveals that small-for-gestational-age status is an independent risk factor for clinical deterioration following systemic steroid tapering or discontinuation, necessitating careful monitoring during this period.
In a randomized crossover trial involving preterm infants in Karachi, automated oxygen control significantly improved the time spent within the target oxygen saturation range and reduced both hypoxemia and hyperoxemia compared to manual titration, without increasing overall oxygen exposure.
This qualitative study of German primary care physicians reveals that enhancing meaningful work and job satisfaction requires shifting from individual task management to a structural framework of interprofessional collaboration, characterized by competence-based role division and improved communication to address increasing workload and bureaucratic pressures.
This paper introduces the Rapid Electroanalytical Device (READ), a portable, label-free multiplex electrochemical biosensing platform that enables non-invasive, longitudinal monitoring of inflammatory bowel disease by simultaneously quantifying eight salivary biomarkers with high accuracy and strong agreement with standard LC-MS methods.
This study demonstrates that combining elastic-band resistance training with nutritional guidance significantly improves muscle mass, physical function, nutritional status, and quality of life in older adults with sarcopenia compared to conventional care alone, while maintaining a comparable safety profile.
This bi-national cross-sectional analysis of the UK Biobank and US Health and Retirement Study demonstrates that higher cumulative adverse childhood experiences are consistently associated with earlier age at menopause and increased odds of early menopause across both cohorts, revealing a significant dose-response relationship that underscores the enduring reproductive consequences of childhood adversity.
A mixed-methods evaluation of Burkina Faso's 2023–2025 Big Catch-Up initiative demonstrates that integrating catch-up vaccination with primary health care services and community engagement successfully reached over 340,000 zero-dose and under-vaccinated children while strengthening routine immunization, despite persistent challenges posed by insecurity and logistical constraints.