📄 Category

medicine

7936 papers

📄 medicine

Real-world outcomes associated with initial oral CGRP receptor antagonist integration strategies in children and adolescents with migraine: a multicenter cohort study

This multicenter cohort study of 109 children and adolescents with migraine found that adding rimegepant to conventional preventive therapy was associated with numerically higher response rates for reducing monthly headache days compared to conventional therapy alone, particularly for achieving a ≥75% reduction, though the primary outcomes did not reach statistical significance, suggesting a need for further prospective evaluation.

Zexian Zhao, Jingxin Fu, Jinyi Song, Mengting Zhou, Feifan Liu, Yuhui Xia, Mengna Yang, Han Xiao Pan, Linli Gao, Jiahuan (…)2026-09-03
📄 medicine

Intra-arterial methylene blue injection for parathyroid preservation in thyroid surgery

This prospective study demonstrates that intra-arterial methylene blue injection is a feasible and effective adjunct for intraoperative parathyroid localization during thyroidectomy, significantly aiding gland preservation when combined with frozen section confirmation despite the dye's limited specificity.

Sonali Sharma, Sarita Asotra, Ishan Chauhan, Ramesh Azad, Sarita Negi, Jagdeep Thakur2026-09-03
📄 medicine

A 10-year Cancer Registry Analysis on Demographic, Clinicopathological, and Treatment Characteristics for Head and Neck Cancer Patients in Zambia

This 10-year retrospective analysis of Zambia's national cancer registry reveals that head and neck cancer predominantly affects males, presents at advanced stages, and is treated primarily with chemotherapy, with oral cavity tumors being most common in adults and nasopharyngeal tumors in adolescents.

Chrispinus Hakimu Mumena, Jenny Öhman, Bengt Hasséus, Christopher Kapeshi, Daniel Giglio2026-09-03
📄 medicine

Psychometric Validation and Cultural Adaptation of the Functional Vision Questionnaire for Children (FVQ-Ar): A COSMIN-Compliant Study

This study successfully cross-culturally adapted and psychometrically validated the Arabic Functional Vision Questionnaire for Children (FVQ-Ar) in Jordan, demonstrating excellent reliability and validity to support evidence-based educational accommodations and inclusive education for visually impaired students in the Middle East.

Ayah Ibrahim Al-Rababah, Muawyah Al Bdour, Yazan Gammoh, Óscar García Espinilla2026-09-03
📄 medicine

Modelling the future population health consequences of precipitation-induced healthcare disruptions in Malawi

This study utilizes a modeling framework integrated with Malawi's Thanzi La Onse health system model to project that precipitation-induced disruptions between 2025 and 2040 will significantly impact acute conditions like neonatal care and respiratory infections, affecting over 7 million people and highlighting the critical need for adaptation planning and improved data on patient behavior.

Rachel Murray-Watson, Tara Mangal, Bingling She, Sangeeta Bhatia, Andrew Philips, Joseph Collins, Timothy Hallett, Margh (…)2026-09-03
📄 medicine

A Case Report on Endometrial Dedifferentiated Carcinoma with a Comprehensive Literature Review

This case report highlights a diagnostic challenge where a rare FIGO stage IA dedifferentiated endometrial carcinoma in a 33-year-old woman was initially misdiagnosed as cervical high-grade neuroendocrine carcinoma, underscoring the critical need for comprehensive tissue sampling and judicious immunohistochemistry to ensure accurate staging and appropriate management.

Yue Huang, Hongxin Yu, Yaqian Feng, Qi Guo, Xiaoxue Wang, Lina Hu, Jingfen Sun, Haixia Shang2026-09-03
📄 medicine

Redesigning Paediatric Emergency Care for Mental Health: A realist, mixed-methods evaluation of a new model of integrated care (Best For You)

This realist, mixed-methods study evaluates the implementation of the "Best For You" integrated care model in Northwest London, revealing that despite significant contextual barriers like the pandemic and infrastructure limitations, persistent stakeholder motivation and adaptive planning enabled the successful redesign of paediatric emergency mental health services.

Michaela Otis, Natasha Dsouza, Susan Barber, Susanna Wratten, Sena Goldal, Stuart Green Hofer, Jean Straus, Michelle Kay (…)2026-09-03
📄 medicine

The Complex Dynamics of Caregiving for ADRD Patients in Uganda: Selection Factors, Challenges, and Benefits

This qualitative study in Uganda reveals that while family caregivers for ADRD patients face significant multidimensional challenges driven by cultural expectations and limited resources, their selection is rooted in relational bonds and their experiences are simultaneously enriched by personal growth, empathy, and a sense of fulfillment, highlighting the urgent need for culturally tailored support interventions.

Joy Louise Gumikiriza- Onoria, Mark Kaddu- Mukasa, Kamada Lwere, Dennis Buwembo, Rita Nassanga, Noeline Nakasujja2026-09-03
📄 medicine

Clinical deterioration after steroid tapering or discontinuation in very-low-birth-weight infants: association with small-for-gestational-age status

This retrospective study of very-low-birth-weight infants reveals that small-for-gestational-age status is an independent risk factor for clinical deterioration following systemic steroid tapering or discontinuation, necessitating careful monitoring during this period.

Masanori Inoue, Yukari Koike, Haruka Tsushita, Ryota Tanaka, Yukie Takumi, Hiroyuki Ono, Ryosuke Tatsuta, Shintaro Kishi (…)2026-09-03
📄 medicine

Automated versus manual oxygen control in preterm infants on respiratory support: a randomised crossover trial

In a randomized crossover trial involving preterm infants in Karachi, automated oxygen control significantly improved the time spent within the target oxygen saturation range and reduced both hypoxemia and hyperoxemia compared to manual titration, without increasing overall oxygen exposure.

Ali Shabbir Hussain, Hafiz Muhammad Aamir Yousuf, Musa Salar, Hashim Salar, Rabia Munir, Georg Schmölzer, Zahra Hoodbhoy (…)2026-09-03