3171 papers
This randomized waitlist-controlled trial demonstrates that an 8-week Group Music and Imagery intervention significantly reduces depressive symptoms and preserves left hippocampal volume in individuals with subclinical depression, offering preliminary multimodal evidence for its potential as a scalable early intervention.
This retrospective study utilizing metagenomic next-generation sequencing demonstrates that antiretroviral therapy in people living with HIV remodels pulmonary microbial communities by selectively suppressing fungal and viral pathogen loads, thereby reducing overall pathogen burden and improving clinical outcomes compared to ART-naïve patients.
This systematic review and meta-analysis of 12 studies indicates that left atrial appendage occlusion (LAAO) significantly reduces major bleeding and cardiac mortality compared to oral anticoagulation in non-valvular atrial fibrillation patients, though it shows no significant difference in stroke prevention or all-cause mortality when accounting for study design heterogeneity.
This pilot study demonstrates that an online, 8-week holistic lifestyle intervention combining nutritional education, physical activity, and socializing is feasible and highly acceptable for older adults with Age-related Macular Degeneration, showing promising trends toward improvements in physical activity, falls self-efficacy, loneliness, and visual function.
In a high-volume center, a prospective comparison of 200 patients undergoing robotic radical prostatectomy found that the new Toumai platform demonstrated equivalent short-term oncological, functional, and complication outcomes to the established da Vinci system, despite longer operative times and a higher rate of extended lymphadenectomies.
This study comparing Sarstedt S-Monovette® and Streck® Cell-Free DNA tubes found that the Sarstedt tubes yielded significantly lower amounts of cell-free DNA on day 0 and exhibited significant leukocyte lysis by day 7, indicating inferior performance relative to the Streck reference standard.
This study demonstrates that a decreased count of POU2F3-positive tuft cells is an independent histological marker significantly associated with high-grade lesions in superficial non-ampullary duodenal epithelial tumors, regardless of mucin phenotype.
This qualitative phenomenological study explores the profound physical, emotional, and economic burdens faced by family caregivers of older adults with dementia in Northern Ethiopia, revealing how the dual pressures of limited resources and post-conflict precarity shape their lived experiences and necessitate urgent, culturally sensitive policy interventions.
This study demonstrates that combining histone deacetylase (HDAC) inhibition with blockade of hypoxia-associated chaperones HSP90β and TRAP1 synergistically disrupts hypoxia signaling, impairs tumor progression, and enhances treatment efficacy in triple-negative breast cancer 3-D models by reprogramming HIF-1α-mediated adaptive pathways.
This retrospective time-series analysis of 2023–2024 data in New York City reveals that the impact of environmental factors on asthma-related emergency department visits varies significantly by season, with PM2.5 driving summer exacerbations, NO2 influencing winter visits, and higher temperatures inversely associated with spring utilization, underscoring the need for seasonally adjusted mitigation strategies.