📄 medicine

Mind the Gap: Autoimmune versus Infectious Encephalitis in Children. A Retrospective Cohort Study from a Tertiary Centre, Riyadh, Saudi Arabia (2020–2026)

This retrospective cohort study of 192 children in Riyadh, Saudi Arabia, demonstrates that a newly developed bedside score incorporating age, psychiatric symptoms, and normal CSF cell counts effectively distinguishes autoimmune encephalitis from infectious encephalitis at presentation, outperforming an adapted adult-derived model.

Faten Al Kateb, Bodoor Sulaimani, Lujain Alsiwat, Zain Khan, Amro Alsalmi, Saadia Tabassum2026-10-22
📄 medicine

α-Synuclein Seed Amplification Status Modifies the Relationship Between Plasma p-tau217, Amyloid and Fibrillar Tau

This study demonstrates that while plasma p-tau217 levels are elevated in Alzheimer's disease patients with concurrent α-synuclein pathology, this elevation is primarily driven by increased fibrillar tau burden rather than assay interference, indicating that plasma p-tau217 remains a reliable diagnostic biomarker even in the presence of Lewy-related pathology.

Íñigo Rodríguez-Baz, Rosa Ferrer, Marc Sans Falip, Elena Vera-Campuzano, Isabel Sala, Lucía Maure-Blesa, Judit Selma-Gon (…)2026-10-22
📄 medicine

Development and internal validation of a prediction model for postoperative vascular compromise following flap reconstruction in patients with diabetic foot ulcers

This study developed and internally validated a prediction model using preoperative fasting glucose and vascular pedicle length to identify patients at risk for postoperative vascular compromise following flap reconstruction for diabetic foot ulcers, aiming to guide intensified early surveillance while acknowledging the need for further validation due to the single-center design and limited event count.

Xiaowen Zhang¹, Jing Yao²#, Ying Cao³, Qing Shi⁴, Yanhua Ning²2026-10-22
📄 medicine

The Effect of Paternal Kangaroo Care on Paternal Role Adaptation in Preterm Infants Hospitalized in Neonatal Intensive Care Units: A Randomized Controlled Trial

This 2025 randomized controlled trial conducted in Iran demonstrates that paternal kangaroo care significantly improves and sustains role adaptation among fathers of preterm infants hospitalized in neonatal intensive care units, supporting its integration as a practical strategy for family-centered care.

Parastoo Yari, Zahra Yazdanpanahi, Reza Bahrami, Mahboubeh Hajifoghaha2026-10-22
📄 medicine

Evaluation Of Splinting Scan Bodies on The Accuracy of Complete-Arch Digital Implant Scans with Different Scanners

This in vitro study found that splinting scan bodies with orthodontic wire, resin, or metal bars did not improve the trueness or precision of complete-arch digital implant scans compared to non-splinted configurations, with the Medit i900 scanner demonstrating superior precision over the Panda P3.

Mohamed Nashat Etman, Ahlam Mostafa El-Sharkawy, Iman Mohamed Sobhy Matar, Doaa Aboul Azm2026-10-22
📄 medicine

Fluorescent lymphography and lymph node retrieval and perioperative outcomes in rectal cancer surgery: a prospective non-randomized cohort study stratified by neoadjuvant chemoradiotherapy

This prospective cohort study demonstrates that fluorescence lymphography improves lymph node retrieval and perioperative outcomes in rectal cancer surgery, particularly for patients not receiving neoadjuvant chemoradiotherapy, although its sensitivity for detecting metastatic lymph nodes remains limited.

Wenlong Qiu¹, Cheng Zhou, Wenhao Zhang, Qian Liu2026-10-22
📄 medicine

Small-airway function and reduced diffusing capacity in hospitalised adults with preserved baseline spirometry: a retrospective cross-sectional study

In a retrospective study of hospitalized adults with preserved spirometry, lower maximal mid-expiratory flow (MMEF) was significantly associated with reduced diffusing capacity for carbon monoxide (DLCO), though adding MMEF to clinical models provided only minimal improvement in diagnostic discrimination.

Ling Lei, Liang He, Xing Zeng, Xijun Gou2026-10-22
📄 medicine

Titanium Mesh Cage Versus Autogenous Strut Graft for Anterior Column Reconstruction in Pyogenic Infectious Spondylitis: Are Outcomes Comparable?

This retrospective study of 45 patients found that titanium mesh cages and autogenous strut grafts yield comparable radiographic and clinical outcomes for anterior column reconstruction in pyogenic infectious spondylitis after adjusting for confounding factors such as age and infection etiology.

Jin-Hwan Kim, Sung Tan Cho, Kyeong-Woo Park, Gyu-Heon Lee, Dong Seok Kim2026-10-22
📄 medicine

Incremental Prognostic Value of the Geriatric Nutritional Risk Index in Mechanically Ventilated Older ICU Patients: A Retrospective Cohort Study

This retrospective cohort study of 285 mechanically ventilated older ICU patients demonstrates that the Geriatric Nutritional Risk Index (GNRI) is an independent predictor of 28-day mortality and provides incremental prognostic value beyond the SOFA score, although it does not independently predict extubation failure.

Duygu Karakose Caliskan, Rifat Burak Ergul2026-10-22
📄 medicine

Clinical and Tomographic Characteristics of Keratoconus Progression in an East Asian Cohort: A Retrospective Study in Taiwan

This retrospective study of an East Asian cohort identifies that baseline localized morphological asymmetry and focal apex decentration, specifically the IHD and IVA indices, are significant predictors of keratoconus progression, outperforming single elevation metrics and systemic comorbidities in characterizing disease instability.

Zhu-Yun Chen, Jin-Jhe Wang2026-10-22