4376 papers
This systematic review of 17 randomized controlled trials found no strong evidence that artificial intelligence-assisted interventions significantly reduce physical inactivity in high-income countries, though they may modestly increase step counts, while highlighting the need for future research to address methodological limitations and equity concerns.
This study demonstrates that an elevated neutrophil-to-lymphocyte ratio (NLR) is independently associated with poorer cognitive function and higher plasma levels of Alzheimer's disease-related biomarkers (GFAP, NfL, and p-tau181), suggesting NLR serves as a cost-effective peripheral indicator of neuroinflammation and cognitive decline in AD.
This case series of four related patients with a confirmed *ATXN3* mutation illustrates the variable expressivity of familial neurodegenerative disorders, where divergent phenotypes ranging from Spinocerebellar Ataxia Type 3 to hereditary spastic paraplegia and neuropathy are accompanied by shared systemic manifestations including hematological anomalies and autonomic dysfunction.
This study validates the ethnomedicinal use of *Ficus thonningii* roots for treating diarrhea by demonstrating that its 80% methanol crude extract and solvent fractions, particularly the aqueous fraction, significantly inhibit castor oil-induced diarrhea, enteropooling, and intestinal motility in Swiss albino mice in a dose-dependent manner.
This mixed-methods study evaluates the pre-launch maturity of the upcoming Hong Kong Centre for Medical Products Regulation (CMPR), identifying current gaps in primary review and real-world evidence integration while proposing a ten-year strategic blueprint to advance its transition to an independent primary authority through workforce development, regulatory innovation, and Greater Bay Area harmonization.
This case study demonstrates that amplitude-modulated kilohertz transcranial magnetic perturbation (AM-kTMP) is a safe and promising non-invasive intervention that improved motor and cognitive function in a 78-year-old patient with cerebellar ataxia following a hemorrhagic stroke.
This paper introduces the EVIDENCE Framework, a practical methodology designed to detect and prevent "evidence recycling"—the AI-driven paraphrasing of existing research that creates an illusion of novelty—by utilizing a dependency matrix to ensure source traceability in global health meta-analyses.
This in vitro study found that while the alkasite material Cention Forte generally exhibited superior shear bond strength to primary dentin compared to glass ionomer cements, silver fluoride pretreatment equalized the performance of all three materials and slightly reduced Cention Forte's bond strength, with aging having a minimal overall effect.
This study demonstrates that DailyCare, a caregiver-mediated chatbot reminder system, is an acceptable and meaningful tool for supporting everyday dementia routines by combining accessible patient interactions with caregiver-driven personalization and monitoring.
This qualitative study of thirteen senior Ayurvedic physicians reveals significant heterogeneity in the application of classical diagnostic theories, indicating that clinical reasoning is often guided by pragmatic experience and ad hoc integration of biomedical concepts rather than a uniform theoretical framework.