4376 papers
This umbrella review of 19 systematic reviews finds that while school and community-based sexual health interventions for youth aged 10–30 effectively improve knowledge, attitudes, and self-reported behaviors, they demonstrate limited impact on critical biological and clinical outcomes such as STI incidence, pregnancy rates, and viral load.
This descriptive survey conducted at an Italian tertiary cancer center reveals that while a majority of healthcare providers lack formal training in Integrative Medicine, they demonstrate a strong interest in education and maintain a positive attitude toward caring for incurable patients, highlighting an urgent need for structured educational pathways to better support patient needs.
This study demonstrates that combining the phytogenic bioenhancer piperine with amoxicillin effectively mitigates antibiotic resistance in metal-tolerant *E. coli* within broiler chickens by inhibiting efflux pumps, enhancing amoxicillin pharmacokinetics, and reducing heavy metal accumulation without compromising safety.
This retrospective cohort study demonstrates that personalized 3D printing-assisted preoperative simulation significantly improves surgical efficiency, reduces intraoperative trauma and complications, and enhances long-term functional recovery for patients with complex tibial plateau fractures compared to conventional surgery.
This case series reports that metformin rapidly improved severe fatigue and cognitive dysfunction in three women with post-COVID-19 condition or aromatase inhibitor-related symptoms, with symptom recurrence upon discontinuation and improvement upon re-initiation, suggesting a potential role for metformin in treating these syndromes linked to suspected mitochondrial dysfunction.
This paper reports a case of bilateral acute angle closure caused by uveal effusion following isatuximab infusion in a multiple myeloma patient, highlighting a potentially underrecognized ocular toxicity of this anti-CD38 therapy that resolved with medical management.
This study developed and validated an interpretable nomogram incorporating vascular, neurological, and metabolic factors to effectively predict 90-day functional outcomes in acute ischemic stroke patients undergoing mechanical thrombectomy, demonstrating robust performance comparable to machine learning models while offering enhanced clinical transparency.
This secondary data analysis reveals that Sri Lanka is undergoing rapid demographic ageing with a 70.8% increase in its elderly population from 2012 to 2024, driving a significant rise in non-communicable disease burdens and a sharp increase in out-of-pocket health expenditures to 54.8%, thereby necessitating urgent, district-specific policy interventions to strengthen geriatric care and financial protection.
This study demonstrates that kidney-targeted AAV9-mediated Klotho gene delivery attenuates renal fibrosis in chronic kidney disease by restoring Klotho levels to inhibit the TGF-β1/Smad3 signaling pathway and upregulate Smad7, thereby improving renal function and reducing extracellular matrix deposition.
This experimental study on rabbits demonstrates that administering sugammadex, particularly in combination with standard atropine and pralidoxime therapy, significantly improves erythrocyte and tissue acetylcholinesterase activity compared to standard treatment alone in acute organophosphate toxicity.